3-[3-(benzo[1,3]dioxol-5-ylamino)-2-phenethyl-imidazo[1,2-a]pyridin-6-yl]-acrylic acid ethyl ester | 910823-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 3-[3-(benzo[1,3]dioxol-5-ylamino)-2-phenethyl-imidazo[1,2-a]pyridin-6-yl]-acrylic acid ethyl ester
• 英文别名: ethyl (E)-3-[3-(1,3-benzodioxol-5-ylamino)-2-(2-phenylethyl)imidazo[1,2-a]pyridin-6-yl]prop-2-enoate
• CAS: 910823-54-0
• 化学式: C₂₇H₂₅N₃O₄
• 分子量: 455.513
• InChiKey: YQEBJJPEYLHKQK-XNTDXEJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  74.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-[3-(benzo[1,3]dioxol-5-ylamino)-2-phenethyl-imidazo[1,2-a]pyridin-6-yl]-acrylic acid ethyl ester 在 盐酸羟胺 、 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 3-[3-(benzo[1,3]dioxol-5-ylamino)-2-phenethyl-imidazo[1,2-a]pyridin-6-yl]-N-hydroxy-acrylamide
  参考文献：
  名称：

  WO2006/101455

  摘要：

  公开号：
• 作为产物：
  描述：

  苯丙醛 、 3-(2-氨基-5-溴-3-吡啶基)丙烯酸乙酯 、 5-异氰基-1,3-苯并二氧戊环 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 以72%的产率得到3-[3-(benzo[1,3]dioxol-5-ylamino)-2-phenethyl-imidazo[1,2-a]pyridin-6-yl]-acrylic acid ethyl ester
  参考文献：
  名称：

  WO2006/101455

  摘要：

  公开号：

文献信息

• IMIDAZO[1,2-A]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
  申请人：Lee C. Ken

  公开号：US20080085896A1

  公开（公告）日：2008-04-10

  The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
• IMIDAZO[1,2-a]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
  申请人：Lee Ken C.

  公开号：US20100105721A1

  公开（公告）日：2010-04-29

  The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
• US7666880B2
  申请人：——

  公开号：US7666880B2

  公开（公告）日：2010-02-23
• US8648092B2
  申请人：——

  公开号：US8648092B2

  公开（公告）日：2014-02-11
• US8901149B2
  申请人：——

  公开号：US8901149B2

  公开（公告）日：2014-12-02