1,2-diethyl-pyrazolidine | 22825-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1,2-diethyl-pyrazolidine
• 英文别名: 1,2-Diethyl-pyrazolidin；N,N'-Diethylpyrazolidin；1,2-Diethylpyrazolidin；Pyrazolidine, 1,2-diethyl-；1,2-diethylpyrazolidine
• CAS: 22825-58-7
• 化学式: C₇H₁₆N₂
• 分子量: 128.217
• InChiKey: GIFQKRUUYUNQGW-UHFFFAOYSA-N

物化性质

• 沸点：
  62 °C(Press: 46 Torr)
• 密度：
  0.878±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-diethyl-pyrazolidine 在 双氧水 作用下， 以 甲醇 为溶剂， 生成 N-[3-(Ethyl-hydroxy-amino)-propyl]-acetamide
  参考文献：
  名称：

  N-hydroxy-diamin-derivate aus hydrazin-N-oxiden

  摘要：

  DOI：

  10.1016/s0040-4039(00)82075-4
• 作为产物：
  描述：

  1,2-diethylhydrazine dihydrochloride 、 1,3-二溴丙烷 在 sodium hydroxide 、 potassium carbonate 作用下， 以 水 为溶剂， 120.0 ℃ 、551.58 kPa 条件下， 反应 0.33h， 以80%的产率得到1,2-diethyl-pyrazolidine
  参考文献：
  名称：

  肼衍生物与烷基二卤化物或二甲苯磺酸盐在水性介质中的微波辅助环缩合反应：吡唑，吡唑烷和邻苯二嗪衍生物的合成

  摘要：

  在微波辐射条件下，在含水介质中，通过烷基二卤化物或二甲苯磺酸盐对肼的双烷基化反应，直接合成4，5-二氢吡唑，吡唑烷和1，2-二氢邻苯二甲酰肼衍生物。有利于环境的化学转化过程一步完成，消除了使用昂贵的金属催化剂来构建两个C–N键的过程。

  DOI：

  10.1016/j.tetlet.2005.07.018

文献信息

• [EN] ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：GILEAD SCIENCES INC

  公开号：WO2010132601A1

  公开（公告）日：2010-11-18

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  这项发明涉及抗病毒化合物，含有这种化合物的组合物，包括给予这种化合物的治疗方法，以及用于制备这种化合物的过程和中间体。
• Microwave-assisted cyclocondensation of hydrazine derivatives with alkyl dihalides or ditosylates in aqueous media: syntheses of pyrazole, pyrazolidine and phthalazine derivatives
  作者：Yuhong Ju、Rajender S. Varma

  DOI：10.1016/j.tetlet.2005.07.018

  日期：2005.9

  Direct syntheses of 4,5-dihydro-pyrazole, pyrazolidine, and 1,2-dihydro-phthalazine derivatives via double-alkylation of hydrazines by alkyl dihalides or ditosylates were accomplished in aqueous media under microwave irradiation conditions; the environmentally friendlier chemical transformation occurred in a single step and eliminated the use of expensive metal catalysts in building two C–N bonds.

  在微波辐射条件下，在含水介质中，通过烷基二卤化物或二甲苯磺酸盐对肼的双烷基化反应，直接合成4，5-二氢吡唑，吡唑烷和1，2-二氢邻苯二甲酰肼衍生物。有利于环境的化学转化过程一步完成，消除了使用昂贵的金属催化剂来构建两个C–N键的过程。
• Methods and compositions of novel triazine compounds
  申请人：Timmer T. Richard

  公开号：US20070099874A1

  公开（公告）日：2007-05-03

  The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

  本发明涉及用于治疗由炎症反应引起的病理生理状态的化合物的方法和组合物。特别地，本发明涉及抑制或阻断糖化蛋白诱导内皮细胞信号相关炎症反应的化合物。本发明涉及抑制平滑肌增殖的化合物。特别地，本发明涉及通过调节HSPG（如Perlecan）来抑制平滑肌细胞增殖的化合物。本发明进一步涉及使用化合物治疗由平滑肌增殖所特征的血管闭塞性疾病，例如再狭窄和动脉粥样硬化。
• OLEFIN-DIENE COPOLYMER AND PROCESS FOR PRODUCING THE SAME
  申请人：Osakada Kohtaro

  公开号：US20080214755A1

  公开（公告）日：2008-09-04

  A copolymer containing units represented by the defined formula (1) and olefin units; and a process for producing the copolymer, which comprises the step of copolymerizing a compound represented by the defined formula (3) with an olefin, the units represented by the formula (1) being polymerized units of the compound represented by the formula (3) such as 5,5-diallyl-2,2-dimethyl-1,3-dioxane.

  一种共聚物，包含由定义公式(1)和烯烃单位表示的单元;以及一种生产该共聚物的方法，其中包括将由定义公式(3)表示的化合物与烯烃共聚的步骤，由公式(1)表示的单元是由公式(3)表示的化合物的聚合单元，例如5,5-二烯基-2,2-二甲基-1,3-二噁烷。
• WATER-ABSORBENT RESIN DISPERSION AND POLYURETHANE COMPOSITION
  申请人：SANYO CHEMICAL INDUSTRIES, LTD.

  公开号：EP0789062A1

  公开（公告）日：1997-08-13

  A water-absorbent resin dispersion comprising a water-absorbent resin (B) or a hydrous gel thereof dispersed in a liquid or heat-meltable organic active-hydrogen compound (A), wherein said resin (B) is formed by the polymerization of a water-soluble monomer or its precursor and a cross-linker and/or a polysaccharide in the compound (A); and a process for producing a polyurethane resin by the reaction of the dispersion with an organic polyisocyanate compound. As the polyurethane resin is excellent in the capacity and rate of absorption, it is useful as absorbent articles such as paper diaper and sanitary goods, humidity modifiers, cutoff material, and so forth.

  一种吸水性树脂分散体，包括分散在液态或可加热熔化的有机活性氢化合物（A）中的吸水性树脂（B）或其水凝胶，其中所述树脂（B）由化合物（A）中的水溶性单体或其前体与交联剂和/或多糖聚合而成；以及一种通过分散体与有机多异氰酸酯化合物反应生产聚氨酯树脂的工艺。由于聚氨酯树脂的吸水能力和吸水速度极佳，因此可用作纸尿布和卫生用品等吸水物品、湿度调节剂、切断材料等。