1-(2-bromo-1-(4-methylbenzyloxy)ethyl)-4-methylbenzene | 1411789-75-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-bromo-1-(4-methylbenzyloxy)ethyl)-4-methylbenzene
• 英文别名: 1-[[2-Bromo-1-(4-methylphenyl)ethoxy]methyl]-4-methylbenzene；1-[[2-bromo-1-(4-methylphenyl)ethoxy]methyl]-4-methylbenzene
• CAS: 1411789-75-7
• 化学式: C₁₇H₁₉BrO
• 分子量: 319.241
• InChiKey: QCKDCKXAKDOBHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (4-甲基苯基)甲醇 、 2-bromo-1-(p-tolyl)ethanol 在 potassium hydrogensulfate 作用下， 以 neat (no solvent) 为溶剂， 以87%的产率得到1-(2-bromo-1-(4-methylbenzyloxy)ethyl)-4-methylbenzene
  参考文献：
  名称：

  KHSO₄-Catalyzed Synthesis of 1,1′-Oxybis(2-bromoethane-1,1-diyl)dibenzenes and 1-(1-(Benzyloxy)-2-bromoethyl)benzenes Under Solvent-Free Conditions

  摘要：

  An economical and green conversion of 2-bromo-1-phenylethanols and benzylic alcohols into 1,1'-oxybis(2-bromoethane-1,1-diyl)dibenzenes and 1-(1-(benyloxy)-2-bromomethy) benzenes catalyzed by KHSO4 under neat condition is described. The present protocol is facile and chemoselective without transition-metal catalyst/solvent, and the KHSO4 catalyst is recyclable.

  DOI：

  10.1080/00397911.2011.604816

文献信息

• KHSO₄-Catalyzed Synthesis of 1,1′-Oxybis(2-bromoethane-1,1-diyl)dibenzenes and 1-(1-(Benzyloxy)-2-bromoethyl)benzenes Under Solvent-Free Conditions
  作者：Girdhar Joshi、Eringathodi Suresh、Subbarayappa Adimurthy

  DOI：10.1080/00397911.2011.604816

  日期：2013.1.1

  An economical and green conversion of 2-bromo-1-phenylethanols and benzylic alcohols into 1,1'-oxybis(2-bromoethane-1,1-diyl)dibenzenes and 1-(1-(benyloxy)-2-bromomethy) benzenes catalyzed by KHSO4 under neat condition is described. The present protocol is facile and chemoselective without transition-metal catalyst/solvent, and the KHSO4 catalyst is recyclable.