thiazol-2-ylmethyltriphenylphosphonium chloride | 115754-94-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: thiazol-2-ylmethyltriphenylphosphonium chloride
• 英文别名: triphenyl-(2-thiazolylmethyl)phosphonium chloride；Triphenyl(1,3-thiazol-2-ylmethyl)phosphanium;chloride
• CAS: 115754-94-4
• 化学式: C₂₂H₁₉NPS*Cl
• 分子量: 395.892
• InChiKey: LDJBOXSVVWHBLS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.64
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  thiazol-2-ylmethyltriphenylphosphonium chloride 在 potassium tert-butylate 作用下， 反应 3.0h， 以90%的产率得到2-thiazolylmethylenetriphenylphosphorane
  参考文献：
  名称：

  噻唑基亚甲基三苯基磷杂环戊烷及其苯并衍生物：合成乙烯基噻唑和乙烯基苯并的稳定和实用的wittig试剂：醛的二碳同系化

  摘要：

  标题的噻唑基磷烷是一种稳定但反应性很强的维蒂希型试剂，与各种醛反应后，可以很好的收率得到主要或仅作为异构体的乙烯基噻唑。而且，与文献报道不同，苯并噻唑基磷烷衍生物证明与醛反应。从噻唑核上进行甲酰基解封的乙烯基噻唑提供了两个碳均化的饱和醛。例如，这些乙烯基噻唑之一，即。β-苯基衍生物8f，证明在甲酰基解封3-苯基庚醛后加-丁基丁基锂锂得到。

  DOI：

  10.1016/s0040-4020(01)90345-x
• 作为产物：
  描述：

  2-氯甲基噻唑 、 三苯基膦 以 苯 为溶剂， 反应 24.0h， 生成 thiazol-2-ylmethyltriphenylphosphonium chloride
  参考文献：
  名称：

  Cruzain的拟肽乙烯基杂环抑制剂可抑制锥虫活性。

  摘要：

  Cruzain是一种寄生虫原生动物Trypanosoma cruzi的必需半胱氨酸蛋白酶，是恰加斯病的重要药物靶标。我们在这里描述了一系列新的可逆但时间依赖性的克鲁赞蛋白酶抑制剂，该抑制剂由附加至乙烯基杂环的二肽支架组成，旨在为克鲁赞蛋白酶的乙烯基砜灭活剂提供不可逆的反应性“弹头”。含Cbz-Phe-Phe / homoPhe-骨架并带有乙烯基-2-嘧啶，乙烯基-2-吡啶和乙烯基-2-（N-甲基）-吡啶基的拟肽乙烯基杂环抑制剂（PVHI）赋予了可逆的，时间依赖性的抑制克鲁萨因（Ki * = 0.1-0.4μM）。与人类组织蛋白酶B，L和S相比，这些Cruzain抑制剂显示出中等至出色的选择性，并且对人细胞没有明显的毒性，但在布鲁氏锥虫锥虫的细胞培养中有效（EC50 = 1-15μM），并在感染的小鼠心肌成纤维细胞中消除了克鲁氏锥虫（EC50 = 5-8μM）。PVHIs是一类新的Cruza

  DOI：

  10.1021/acs.jmedchem.9b02078

文献信息

• Synthesis of nonlinear optical chromophores containing electron-excessive and -deficient heterocyclic bridges. The auxiliary donor–acceptor effects
  作者：Ching-fong Shu、Yuh-kai Wang

  DOI：10.1039/a708689j

  日期：——

  Push-pull substituted nonlinear optical chromophores with thiazole and thiophene rings and interposed ethylene units as π-conjugated bridges were synthesized. The effects of the nature and location of the heterocycles on the energy of the charge transfer transition for the chromophores are discussed.

  合成了具有噻唑和噻吩环及夹杂乙烯单元作为π-共轭桥的推拉取代非线性光学染料。讨论了杂环的性质和位置对染料电荷转移跃迁能量的影响。
• Hydrazine derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US06235787B1

  公开（公告）日：2001-05-22

  Hydrazine derivatives of the formula wherein Y is CO or SO2; R1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R2 is lower alkyl, halo-lower alkyl, aryl-lower alkyl, aryl-lower alkenyl or aryl when Y is SO2 and is lower alkyl, halo-lower alkyl, lower alkoxy, lower alkoxycarbonyl, acyl, lower cycloalkyl, aryl, aryl-lower alkyl, aryl-lower alkoxy or NR5R6 when Y is CO; and R3 is hydrogen, lower alkyl optionally substituted by cyano, amino, hydroxy, lower alkoxy, lower alkoxycarbonyl, heterocyclyl or heterocyclylcarbonyl, lower alkenyl, lower alkynyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl or heterocyclyl; or R2 and R3 together form the residue of a 5-, 6- or 7-membered cyclic amide, cyclic imide, cyclic sulphonamide or cyclic urethane group; R4 is lower alkyl, hydroxy-lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl or a group of the formula X-aryl, X-heteroaryl or —(CH2)1-2—CH═CR7R8; X is a spacer group; R5 and R6 each individually are hydrogen, lower alkyl or aryl-lower alkyl; and R7 and R8 together represent a lower alkylene group in which one methylene group is optionally replaced by a hetero atom; and their pharmaceutically acceptable salts inhibit not only the release of tumour necrosis factor (TNF-&agr;) and transforming growth factor (TGF-&agr;) from cells, but also keratinocyte proliferation. They are useful as medicaments, especially for the treatment of inflammation, fever, hemorrhage, sepsis, rheumatoid arthritis, osteoarthritis, multiple sclerosis or psoriasis.

  氢肼衍生物的化学式为其中Y为CO或SO2；R1为较低的烷基、较低的烯基、较低的环烷基、较低的环烷基-烷基、芳基或芳基-烷基；R2为较低的烷基、卤代较低的烷基、芳基-烷基、芳基-烯基或芳基（当Y为SO2时），且为较低的烷基、卤代较低的烷基、较低的烷氧基、较低的烷氧羰基、酰基、较低的环烷基、芳基、芳基-烷基、芳基-烷氧基或NR5R6（当Y为CO时）；R3为氢、较低的烷基（可选择地被氰基、氨基、羟基、较低的烷氧基、较低的烷氧羰基、杂环烷基或杂环烷基羰基取代）、较低的烯基、较低的炔基、较低的环烷基、较低的环烷基-烷基、芳基-烷基、芳基-烯基、芳基或杂环烷基；或者R2和R3一起形成5、6或7成员环酰胺、环亚胺、环磺胺或环脲基团的残基；R4为较低的烷基、羟基-较低的烷基、较低的烯基、较低的环烷基、较低的环烷基-烷基或具有X-芳基、X-杂环芳基或—(CH2)1-2—CH═CR7R8的基团；X为间隔基团；R5和R6各自为氢、较低的烷基或芳基-烷基；R7和R8一起代表较低的烷基烯基，其中一个亚甲基团可选择地被杂原子取代；它们的药学上可接受的盐不仅抑制肿瘤坏死因子（TNF-α）和转化生长因子（TGF-α）从细胞中的释放，还抑制角质细胞增殖。它们可用作药物，特别用于治疗炎症、发热、出血、败血症、类风湿性关节炎、骨关节炎、多发性硬化或牛皮癣。
• Thiazolylmethylenetriphenylphosporane and its benzo derivative: stable and practical wittig reagents for the synthesis of vinylthiazoles and vinylbenzo
  作者：Alessandro Dondoni、Giancarlo Fantin、Marco Fogagnolo、Alessandro Medici、Paola Pedrini

  DOI：10.1016/s0040-4020(01)90345-x

  日期：1988.1

  is a stable yet quite reactive Wittig-type reagent which upon reaction with various aldehydes affords vinylthiazoles, mainly or exclusively as -isomers, in very good yields. Also the benzothiazolyl phosphorane derivative, unlike a literature report, prove to react with aldehydes. Vinylthiazoles subjected to formyl deblocking from thiazole nucleous afford two-carbon homologated satured aldehydes. As

  标题的噻唑基磷烷是一种稳定但反应性很强的维蒂希型试剂，与各种醛反应后，可以很好的收率得到主要或仅作为异构体的乙烯基噻唑。而且，与文献报道不同，苯并噻唑基磷烷衍生物证明与醛反应。从噻唑核上进行甲酰基解封的乙烯基噻唑提供了两个碳均化的饱和醛。例如，这些乙烯基噻唑之一，即。β-苯基衍生物8f，证明在甲酰基解封3-苯基庚醛后加-丁基丁基锂锂得到。
• [EN] 4-CARBOX PYRAZOLE DERIVATES USEFUL AS ANTI-VIRAL AGENTS<br/>[FR] DÉRIVÉS DE 4-CARBOX PYRAZOLE UTILES EN TANT QU'AGENTS ANTIVIRAUX
  申请人：GLAXO GROUP LTD

  公开号：WO2005092863A1

  公开（公告）日：2005-10-06

  Novel antiviral compounds of Formula (I) : wherein: A represents hydroxy; R1 represents aryl, heteroaryl bonded through a ring carbon atom, or heterocyclyl bonded through a ring carbon atom, C1-6alkyl or -C5-9cycloalkyl, each of which may be optionally substituted; R2 represents substituted phenyl, or -(CH2)nC5-7cycloalkyl optionally substituted on the cycloalkyl; R3 represents heterocyclyl or heteroaryl; optionally substituted phenyl or optionally substituted -C1-6alkyl; R4 represents hydrogen; and salts, solvates and esters thereof, processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.

  化合物的新型抗病毒化合物的结构式（I）：其中：A代表羟基；R1代表芳基，通过一个环碳原子结合的杂环芳基，或者通过一个环碳原子结合的杂环烷基，C1-6烷基或-C5-9环烷基，每种基团可以选择性地被取代；R2代表取代苯基，或者选择性地被取代的-(CH2)nC5-7环烷基；R3代表杂环烷基或杂环芳基；或者选择性地被取代的苯基或选择性地被取代的-C1-6烷基；R4代表氢；以及它们的盐、溶剂合物和酯，提供了其制备方法、包含它们的药物组合物，以及在HCV治疗中使用它们的方法。
• Synthesis and characterization of thiazole-containing chromophores for second-order nonlinear optics
  作者：Yuh-Kai Wang、Ching-Fong Shu、Eric M. Breitung、Robert J. McMahon

  DOI：10.1039/a900820i

  日期：——

  Push-pull thiazole-containing nonlinear optical chromophores with dicyanovinyl and tricyanovinyl acceptors, along with their thiophene analogs, have been synthesized and characterized. The onset temperatures of thermal decomposition of these chromophores determined by DSC are above 240 °C. The redox properties of the chromophores were studied by cyclic voltammetry and the results reveal the electron-deficient (thiazole) and electron-excessive (thiophene) nature of the heterocycles. Experimental measurements of second-order nonlinear optical response (µ·β) indicate that the combination of either a thiazole or thiophene conjugating unit and a tricyanovinyl acceptor results in a nonlinear optical chromophore exhibiting substantial molecular hyperpolarizability (µ·βca. 7000×10 –48 cm 6 at 1907 nm).

  我们合成并鉴定了含有二氰基乙烯基和三氰基乙烯基受体的推拉式噻唑非线性光学发色团及其噻吩类似物。通过 DSC 测定，这些发色团的热分解起始温度高于 240 ℃。通过循环伏安法研究了这些发色团的氧化还原性质，结果表明这些杂环具有缺电子（噻唑）和得电子（噻吩）的性质。二阶非线性光学响应（µ-β）的实验测量结果表明，噻唑或噻吩共轭单元与三氰基乙烯基受体的组合会产生一种非线性光学发色团，表现出很强的分子超极化性（1907 纳米波长处的µ-β约为 7000×10 -48 cm 6）。