3,3-diethoxy-1-propyl tosylate | 767321-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-diethoxy-1-propyl tosylate
• 英文别名: 3,3-Diethoxypropyl 4-methylbenzenesulfonate；3,3-diethoxypropyl 4-methylbenzenesulfonate
• CAS: 767321-23-3
• 化学式: C₁₄H₂₂O₅S
• 分子量: 302.392
• InChiKey: IMUQNGIQHMCJBY-UHFFFAOYSA-N

物化性质

• 沸点：
  414.5±40.0 °C(Predicted)
• 密度：
  1.136±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  70.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,3-二乙氧基-1-丙醇 、 对甲苯磺酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 24.0h， 生成 3,3-diethoxy-1-propyl tosylate
  参考文献：
  名称：

  Versatile Synthesis of End-Functionalized Thermosensitive Poly(2-isopropyl-2-oxazolines)

  摘要：

  The synthesis of several end-functionalized poly(2-isopropyl-2-oxazolines) (PiPrOx) has been achieved via cationic ring-opening polymerization of 2-isopropyl-2-oxazoline. Poly(2-isopropyl-2-oxazolines) bearing primary amino groups at one chain end (Me-PiPrOx-NH2, with M. ranging from 3600 to 9700) were obtained by conversion of hydroxyl-terminated poly(2-isopropyl-2-oxazolines) (Me-PiPrOx-OH) via phthalimide activation of the hydroxl groups and subsequent hydrazine treatment. Heterotelechelic PiPrOx carrying an alpha-acetal and an omega-hydroxyl group (acetal-PiPrOx-OH) were prepared via cationic ring-opening polymerization of 2-isopropyl-2-oxazoline initiated with 3,3-diethoxy-1-propyl tosylate. The polymerizations carried out under mild conditions (40-45 degreesC) for extended periods of time yielded polymers of well-controlled molecular weight (MW) and narrow molecular weight distribution (MWD). Analysis of the polymers by H-1 and C-13 NMR spectroscopy, ion-exchange HPLC, and MALDI-TOF mass measurements indicated that nearly quantitative end-functionalization was achieved in all cases. Aqueous PiPrOx solutions (10 mM PBS (pH 7.4) containing 150 mM NaCl) possess a cloud point temperature near 37 degreesC, as determined by turbidity. Thermosensitive telechelic PiPrOx offer promising applications as smart materials including bioconjugates, hydrogels, and drug carriers.

  DOI：

  10.1021/ma049677n

文献信息

• RANDOM COPOLYMER OF OXAZOLINE
  申请人：Japan Science and Technology Agency

  公开号：EP1930361A1

  公开（公告）日：2008-06-11

  The invention provides approximately monodispersible random copolymers obtained from monomeric mixtures of 2-ethyl-2-oxazoline with 2-isopropyl-2-oxazoline, production method thereof and 2-isopropyl-2-oxazoline homopolymer obtained by using special initiator. Such polymers exhibit temperature-responsiveness in an aqueous solution within a broad temperature range, and are useful materials in the technical fields of surface chemistry and biomaterials.

  本发明提供了由 2-乙基-2-噁唑啉与 2-异丙基-2-噁唑啉的单体混合物获得的近似单分散无规共聚物、其生产方法以及使用特殊引发剂获得的 2-异丙基-2-噁唑啉均聚物。这种聚合物在水溶液中可在较宽的温度范围内表现出温度响应性，是表面化学和生物材料技术领域的有用材料。
• Random copolymers of oxazoline
  申请人：Kataoka Kazunori

  公开号：US20090156782A1

  公开（公告）日：2009-06-18

  The invention provides approximately monodispersible random copolymers obtained from monomeric mixtures of 2-ethyl-2-oxazoline with 2-isopropyl-2-oxazoline, production method thereof and 2-isopropyl-2-oxazoline homopolymer obtained by using special initiator. Such polymers exhibit temperature-responsiveness in an aqueous solution within a broad temperature range, and are useful materials in the technical fields of surface chemistry and biomaterials.
• US7732561B2
  申请人：——

  公开号：US7732561B2

  公开（公告）日：2010-06-08