(4R)-4-[3,5-bis(trifluoromethyl)phenyl]-1,1,1-trifluoro-4-(7-methyl-1H-indol-3-yl)butan-2-one | 1245186-62-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4R)-4-[3,5-bis(trifluoromethyl)phenyl]-1,1,1-trifluoro-4-(7-methyl-1H-indol-3-yl)butan-2-one
• CAS: 1245186-62-2
• 化学式: C₂₁H₁₄F₉NO
• 分子量: 467.334
• InChiKey: HKSFLQVOHQYOAH-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  7-甲基吲哚 、 4-[3,5-Bis(trifluoromethyl)phenyl]-1,1,1-trifluorobut-3-en-2-one 在 (S)-3,3'-bis(9-anthracenyl)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate 作用下， 以 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 72.0h， 生成 (4R)-4-[3,5-bis(trifluoromethyl)phenyl]-1,1,1-trifluoro-4-(7-methyl-1H-indol-3-yl)butan-2-one 、 (4S)-4-[3,5-bis(trifluoromethyl)phenyl]-1,1,1-trifluoro-4-(7-methyl-1H-indol-3-yl)butan-2-one
  参考文献：
  名称：

  Chiral Brønsted acid-catalyzed regio- and enantioselective arylation of α,β-unsaturated trifluoromethyl ketones

  摘要：

  The interesting examples of chiral phosphoric acid-catalyzed regio- and enantioselective arylation of alpha,beta-unsaturated trifluoromethyl ketones were reported. The reaction proceeded well and the desired products were obtained in good yields (up to 99%) with moderate to good enantioselectivities (up to 88% ee). Several desired products were obtained with excellent optical purities after a single recrystallization. Subsequent reduction of enantiopure products with NaBH4 afforded two diastereomers of chiral trifluoromethyl-substituted secondary alcohols with high enantioselectivities (98% ee). (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.06.132

文献信息

• Chiral Brønsted acid-catalyzed regio- and enantioselective arylation of α,β-unsaturated trifluoromethyl ketones
  作者：Zeng-kai Pei、Yan Zheng、Jing Nie、Jun-An Ma

  DOI：10.1016/j.tetlet.2010.06.132

  日期：2010.9

  The interesting examples of chiral phosphoric acid-catalyzed regio- and enantioselective arylation of alpha,beta-unsaturated trifluoromethyl ketones were reported. The reaction proceeded well and the desired products were obtained in good yields (up to 99%) with moderate to good enantioselectivities (up to 88% ee). Several desired products were obtained with excellent optical purities after a single recrystallization. Subsequent reduction of enantiopure products with NaBH4 afforded two diastereomers of chiral trifluoromethyl-substituted secondary alcohols with high enantioselectivities (98% ee). (C) 2010 Elsevier Ltd. All rights reserved.