structure could not be determined with absolute certainty by NMR. Therefore, X‐ray crystallography was used to prove that the benzyl group was attached to N‐3. Furthermore, it is shown that the 3‐benzyl adenine derivative exists as the amine tautomer both in the crystalline state as well as in solution (DMSO‐d6), with restricted rotation around the N6C6 bond. J. Heterocyclic Chem., (2011).
在碱存在下将
8-溴腺嘌呤苄基化,得到两种区域异构体的混合物。一个很容易被识别为9-苄基-
8-溴腺嘌呤,但另一个结构不能通过NMR绝对确定。因此,X射线晶体学被用来证明苄基连接到N-3上。此外,结果表明,
3-苄基腺嘌呤衍
生物存在作为胺互变异构体都在晶态,以及在溶液(
DMSO- d 6)中,用围绕所述N个受限制的旋转6 C6键。J.杂环化学。(2011)。