A Fluorous-Tagged “Safety Catch” Linker for Preparing Heterocycles by Ring-Closing Metathesis
作者:Catherine O’Leary-Steele、Christopher Cordier、Jerome Hayes、Stuart Warriner、Adam Nelson
DOI:10.1021/ol802848j
日期:2009.2.19
fluorous-tagged “safety catch” linker is described for the synthesis of heterocycles with use of ring-closing metathesis. The linker facilitiates the purification of metathesis substrates, the removal of the catalyst, the functionalization of the products, and the release of only metathesis products. The synthesis of a range of heterocycles is described.
Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter- and Intramolecular Diels-Alder Reactions
作者:Catherine O'Leary-Steele、Palle J. Pedersen、Thomas James、Thomas Lanyon-Hogg、Stuart Leach、Jerome Hayes、Adam Nelson
DOI:10.1002/chem.201000707
日期:2010.8.16
synthetic accessibility of smallmolecules. Historically, however, chemists have explored chemical space in an exceptionally uneven and unsystematic way. We have previously demonstrated that metathesiscascade chemistry may be harnessed to yield smallmolecule collections with highscaffolddiversity. Here, we describe the extent to which inter‐ and intramolecularDiels–Alderreactions, when used in conjunction