2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one | 118877-07-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡嗪类
• 英文名称: 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one
• 英文别名: 2-methyl-6-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one；MCLA；6-(4-methoxyphenyl)-2-methyl-7H-imidazo[1,2-a]pyrazin-3-one
• CAS: 118877-07-9
• 化学式: C₁₄H₁₃N₃O₂
• 分子量: 255.276
• InChiKey: NQQVXADOIMWVFD-UHFFFAOYSA-N

物化性质

• 沸点：
  381.9±52.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.98
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  59.91
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one 在 氧气 、 四甲基胍 作用下， 以 乙腈 为溶剂， 生成 N-[5-(4-甲氧基苯基)吡嗪-2-基]乙酰胺
  参考文献：
  名称：

  取代基对6-芳基咪唑并[1,2- a ]吡嗪-3（7 H）-ones（赛普卢迪斯荧光素类似物）化学发光反应动力学的影响：支持具有三重态分子的单电子转移（SET）-加氧机理氧

  摘要：

  2-甲基-6-苯基咪唑并[1,2- a ]吡嗪-3（7 H）-one（1c，Cypridina luciferin类似物）化学发光反应的动力学和衍生物1的6-芳基的取代作用强烈表明速率确定步骤是在氧化过程中从1衍生的阴离子到三重态分子氧（O 2）的单电子转移。

  DOI：

  10.1016/j.tetlet.2005.09.014
• 作为产物：
  描述：

  anisole;(2R,3R,5R,6R)-2-(hydroxymethyl)-6-(2-methylimidazo[1,2-a]pyrazin-3-yl)oxyoxane-3,4,5-triol 生成 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one
  参考文献：
  名称：

  Mitani Motohiro, Sakaki Syujiro, Koinuma Yasumi, Toya Yoshiaki, Kosugi Ma+, Anal. Sci., 10 (1994) N 5, S 813-814

  摘要：

  DOI：

文献信息

• Reagents and methods for direct labeling of nucleotides
  申请人：Naleway John J.

  公开号：US20130150254A1

  公开（公告）日：2013-06-13

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活重氮衍生物以用于标记核苷酸的系统和方法。通过将可检测基团的稳定的肼酰肼衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成核苷酸的标记。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，所有类型的核苷酸都可以在不经过扩增或改变的情况下进行标记。
• Influence of Electron-Donating and Electron-Withdrawing Substituents on the Chemiluminescence Behavior of Coelenterazine Analogs
  作者：Ryota Saito、Takashi Hirano、Shojiro Maki、Haruki Niwa、Mamoru Ohashi

  DOI：10.1246/bcsj.20100185

  日期：2011.1.15

  Coelenterazine analogs 3a–3e possessing various substituents at the para-position of the 6-phenyl group (R = CF3, F, H, OMe, and NMe2) were synthesized, and the chemiluminescent properties of 3a–3e...

  合成了在 6-苯基（R = CF3、F、H、OMe 和 NMe2）的对位具有各种取代基的腔肠素类似物 3a-3e，并且 3a-3e 的化学发光特性...
• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Koster Hubert

  公开号：US20050042771A1

  公开（公告）日：2005-02-24

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了用于分析生物分子的捕获化合物和其集合以及使用这些化合物的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂蛋白质混合物。还提供了执行这些方法的自动化系统。
• REAGENTS AND METHODS FOR DIRECT LABELING OF NUCLEOTIDES
  申请人：MARKER GENE TECHNOLOGIES, INC.

  公开号：US20150152476A1

  公开（公告）日：2015-06-04

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活的重氮衍生物以用于标记核苷酸的系统和方法。标记核苷酸是通过将可检测基团的稳定肼基衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成的。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，因此所有类型的核苷酸都可以在不进行扩增或改变的情况下进行标记。
• INHIBITOR OF DENATURED LDL FORMATION
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP0515684A1

  公开（公告）日：1992-12-02

  A pharmaceutical composition containing as the active ingredient a compound which presents low-density lipoproteins (LDL) represented by the compounds of formula (I) from being negatively charged. This composition inhibits the LDL from undergoing denaturation (oxidation) necessary for the recognition by a scavenger acceptor, and is used for treating arteriosclerosis, peptic ulcer, cancer, ischemic organ disease, inflammation and pulmonary silicosis.

  一种药物组合物，其活性成分是一种能使以式（I）化合物为代表的低密度脂蛋白（LDL）不带负电荷的化合物。这种组合物能抑制低密度脂蛋白发生清道夫接受体识别所需的变性（氧化），用于治疗动脉硬化、消化性溃疡、癌症、缺血性器官疾病、炎症和肺矽肺。