(1-fluoroheptyl)benzene | 1428331-74-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-fluoroheptyl)benzene
• 英文别名: 1-Fluoroheptylbenzene
• CAS: 1428331-74-1
• 化学式: C₁₃H₁₉F
• 分子量: 194.292
• InChiKey: CSACECFBNJQROP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  庚基苯 在 iron(II) acetylacetonate 、 Selectfluor 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以68%的产率得到(1-fluoroheptyl)benzene
  参考文献：
  名称：

  Iron(II)-Catalyzed Benzylic Fluorination

  摘要：

  Direct C-F functionalization of benzylic sp(3) C-H bonds is a synthetic challenge that has yet to be propitiously overcome. A mild, one-pot synthesis of monofluorinated benzylic substrates is reported with commercially available iron(II) acetylacetonate and Selectfluor in good to excellent yields and selectivity. A convenient route to beta-fluorinated products of 3-aryl ketones is also highlighted, providing a synthetic equivalent to the difficult to accomplish conjugate addition of fluoride to alpha,beta-unsaturated ketones.

  DOI：

  10.1021/ol400424s

文献信息

• Silver-Catalyzed Decarboxylative Alkylfluorination of Alkenes
  作者：Chen-Guang Li、Qiang Xie、Xiao-Lan Xu、Feng Wang、Bei Huang、Yu-Feng Liang、Hua-Jian Xu

  DOI：10.1021/acs.orglett.9b03381

  日期：2019.10.18

  with the catalysis of silver(I) and Selectfluor as both the oxidant and fluorine source. This reaction is highly chemoselective, producing the decarboxylative alkylfluorination products rather than the competitive fluorination of aliphatic carboxylic acids. This practical transformation proceeds efficiently in aqueous media at room temperature and exhibits a large range of functional-group tolerance

  以银（I）和Selectfluor作为氧化剂和氟源的催化作用，开发了用于烷基烯烃氟化的烷基羧酸脱羧剂。该反应是高度化学选择性的，产生脱羧烷基氟化产物，而不是脂肪族羧酸的竞争性氟化。这种实际的转变在室温下在水性介质中有效地进行，并且在各种伯和仲脂肪族羧酸盐和烯烃中表现出大范围的官能团耐受性。
• Method for producing an aromatic compound having an alkyl group with at least three carbon atoms
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0985649A2

  公开（公告）日：2000-03-15

  Aromatic compounds having an alkyl group with at least 3 carbon atoms are produced in a process comprising at least one of the following steps: (1) a step of contacting a starting material that contains an aromatic compound having a branched alkyl group with at least 3 carbon atoms, with a zeolite-containing catalyst in a liquid phase in the presence of hydrogen therein, thereby changing the position of the carbon atoms of the alkyl group bonding to the aromatic ring of the compound; (2) a step of contacting a starting material that contains an aromatic compound having a branched alkyl group with at least 3 carbon atoms, with a catalyst containing zeolite and containing rhenium and/or silver, in a liquid phase, thereby changing the position of the carbon atoms of the alkyl group bonding to the aromatic ring of the compound; (3) a step of contacting a halogenated aromatic compound having an alkyl group with at least 3 carbon atoms, with an acid-type catalyst, thereby isomerizing the compound; and (4) a step of treating a mixture of isomers of an aromatic compound having an alkyl group with at least 3 carbon atoms, with a zeolite adsorbent that contains at least one exchangable cation selected from alkali metals, alkaline earth metals, lead, thallium and silver, thereby separating a specific isomer from the isomer mixture through adsorption.

  具有至少 3 个碳原子烷基的芳香族化合物的生产工艺至少包括以下一个步骤： (1) 将含有至少 3 个碳原子的支链烷基的芳香族化合物的起始原料在液相中与含沸石的催化剂在氢存在的情况下接触，从而改变烷基的碳原子与化合物的芳香环键合的位置； (2) 将含有芳香族化合物的起始原料与含沸石和含铼和/或银的催化剂在液相中接触，该芳香族化合物具有至少 3 个碳原子的支链烷基，从而改变烷基碳原子与化合物芳香环键合的位置； (3) 将具有至少 3 个碳原子的烷基的卤代芳香族化合物与酸型催化剂接触，从而使该化合物异构化；以及 (4) 用沸石吸附剂处理具有至少 3 个碳原子的烷基的芳香族化合物的异构体混合物，该沸石吸附剂含有至少一种选自碱金属、碱土金属、铅、铊和银的可交换阳离子，从而通过吸附从异构体混合物中分离出特定的异构体。
• US6462248B1
  申请人：——

  公开号：US6462248B1

  公开（公告）日：2002-10-08