4-(1-hydroxyethyl)-1-octylbenzene | 125574-51-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1-hydroxyethyl)-1-octylbenzene
• 英文别名: 4-octylphenylethyl alcohol；1-(4-octyl-phenyl)-ethanol；1-(4-Octyl-phenyl)-aethanol；1-(4-Octylphenyl)ethanol
• CAS: 125574-51-8
• 化学式: C₁₆H₂₆O
• 分子量: 234.382
• InChiKey: WHQUQRIACOUTIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(1-hydroxyethyl)-1-octylbenzene 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 1.1h， 以90%的产率得到4-正辛基苯乙烯
  参考文献：
  名称：

  [EN] NOVEL METHOD FOR PREPARING STYRENIC OLEFINS
  [FR] NOUVELLE METHODE DE PREPARATION D'OLEFINES STYRENIQUES

  摘要：

  本发明涉及一种制备苯乙烯烯烃的方法。本发明的方法包括以下步骤：在反应器中加入催化剂和溶剂，加热反应器以形成回流状态；以恒定速率滴加醇起始物到反应器中；将由于加入醇起始物而产生的水从反应器中去除；并纯化所得的苯乙烯烯烃。本发明的方法有利于最小化副产物，并以高收率制备具有多种取代基的苯乙烯烯烃。

  公开号：

  WO2005035468A1
• 作为产物：
  描述：

  1-苯基辛烷 在 sodium tetrahydroborate 、 三氯化铝 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 7.0h， 生成 4-(1-hydroxyethyl)-1-octylbenzene
  参考文献：
  名称：

  Syndiospecific Synthesis of Longer p-n-Alkyl-Substituted Polystyrenes Using Monocyclopentadienyl-Type Titanium Catalysts

  摘要：

  Substituted styrenes with linear alkyl substituents (C-6 to C-12) at the Para position on the ring were synthesized and polymerized using the (Me)(5)CpTi(OMe)(3)/MAO catalytic system. Increased polymerization activities were observed for longer alkyl group (>C-6) substituted styrenes; all resulting polymers were highly syndiospecific (>99% rr) regardless of alkyl chain lengths. Syndiotactic poly(p-alkylstyrene)s were characterized by SEC, H-1 and C-13 NMR, DSC, and X-ray diffraction. No melting transition was observed for polymers prepared from p-methyl-, p-n-hexyl, and p-n-octylstyrenes. Side-chain-induced crystallization was observed for linear C-10 and C-12 alkyl-substituted polystyrenes (T-m approximate to 90 degreesC). The T-g decreased with an increase in the length of alkyl side chain up to C-8 length; above C-10 side-chain length, the T-g slightly increased. The T-g's of syndiotactic poly(p-n-alkylsyrene)s were significantly higher than those reported for the corresponding nontactic analogues.

  DOI：

  10.1021/ma035947a

文献信息

• Sustainable synthesis of quinolines (pyridines) catalyzed by a cheap metal Mn(I)‐NN complex catalyst
  作者：Huining Chai、Weiqiang Tan、Yuanyuan Lu、Guangyao Zhang、Jiping Ma

  DOI：10.1002/aoc.5685

  日期：2020.8

  example of a bidentate phosphine‐free manganese(I)‐NN complex catalyst for the synthesis of quinolines (pyridines) through acceptorless dehydrogenative condensation of various secondary alcohols with amino alcohols. The coupling reactions occurred at 3 mol% catalyst loading and 110°C, and tolerated diverse functional groups. Moderate to excellent yields ranging from 45% to 89% were achieved after 12

  这项研究代表了一种无二齿膦的锰（I）-NN络合物催化剂的第一个实例，该催化剂通过各种仲醇与氨基醇的无受体脱氢缩合反应合成喹啉（吡啶）。偶合反应发生在催化剂负载为3 mol％和110°C的条件下，并能耐受各种官能团。反应12小时后，中度至出色的收率在45％至89％之间。本协议提供了一种简明且环保的方法来构建杂环化合物。
• [EN] NOVEL METHOD FOR PREPARING STYRENIC OLEFINS<br/>[FR] NOUVELLE METHODE DE PREPARATION D'OLEFINES STYRENIQUES
  申请人：LG CHEMICAL LTD

  公开号：WO2005035468A1

  公开（公告）日：2005-04-21

  The present invention relates to a method for preparing a styrenic olefin. The method of the present invention comprises the steps of: adding a catalyst and a solvent in a reactor and heating the reactor to create a reflux state; adding an alcohol starting material to the reactor dropwise at a constant rate; removing water generated by adding the alcohol starting material from the reactor; and purifying the obtained styrenic olefin. The method of the present invention is advantageous in minimizing byproducts and preparing styrenic olefins having a variety of substituents in high yield.

  本发明涉及一种制备苯乙烯烯烃的方法。本发明的方法包括以下步骤：在反应器中加入催化剂和溶剂，加热反应器以形成回流状态；以恒定速率滴加醇起始物到反应器中；将由于加入醇起始物而产生的水从反应器中去除；并纯化所得的苯乙烯烯烃。本发明的方法有利于最小化副产物，并以高收率制备具有多种取代基的苯乙烯烯烃。
• Phosphate derivatives as immunoregulatory agents
  申请人：——

  公开号：US20020091105A1

  公开（公告）日：2002-07-11

  Immunoregulatory compounds are disclosed of the formula: 1 and 2 as well as the pharmaceutically acceptable salts and hydrates thereof, are disclosed. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

  揭示了具有以下式子的免疫调节化合物：1和2以及其药用盐和水合物。这些化合物可用于治疗免疫介导的疾病和状况，如骨髓、器官和组织移植排斥。包括药物组成和使用方法。
• Polymer compounds
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0403271A3

  公开（公告）日：1992-02-12

  Polymers of structure (I) in which X is a co-monomer unit; X1 is a cross-linking unit; R1 is a saturated or unsaturated C6 to C20 alkyl group; R2 and R3 are the same or different and are each C1 -4alkyl; Y - is a physiologically acceptable counter ion; and a, b and c are numbers which indicate the relative molar percentages of the units present in a random distribution in said polymer, (b) being from about 0.5 to about 10 molar percent and (c) being from about 30 to about 99 molar percent, processes for their prepapration, pharmaceutical compositions containing them, and their use in therapy as cholesterol lowering agents.

  结构式（I）的聚合物中，其中X是共聚单元; X1是交联单元; R1是饱和或不饱和的C6至C20烷基基团; R2和R3相同或不同，均为C1-4烷基; Y-是生理上可接受的反离子; a、b和c是数字，表示在所述聚合物中存在的单元的相对摩尔百分比，其中（b）为约0.5至约10摩尔百分比，（c）为约30至约99摩尔百分比，其制备方法、含有它们的制药组合物以及它们作为降低胆固醇药物的治疗用途。
• Polystyrene anion exchange polymer pharmaceutical composition
  申请人：Smith Kline & French Laboratories Limited

  公开号：US05230885A1

  公开（公告）日：1993-07-27

  Polystyrene polymers having a quaternised ammonium group and their use in a method of treatment of hypercholesterolaemia. A particular compound of the invention is (N,N-dimethyl-N-dodecyl-ammoniomethylstyrene-ethyl methacrylate-divinylbenzene co-polymer, chloride salt.

  聚苯乙烯聚合物具有季铵基团及其在治疗高胆固醇血症方法中的应用。发明中的一种特定化合物是（N，N-二甲基-N-十二烷基-铵甲基苯乙烯-乙基丙烯酸甲酯-二乙烯基苯共聚物，氯化物盐）。