(-)-2-pyrrolidin-3ylphenol | 352232-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (-)-2-pyrrolidin-3ylphenol
• 英文别名: 2-(Pyrrolidin-3-yl)phenol；2-pyrrolidin-3-ylphenol
• CAS: 352232-05-4
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: DFLVWVRCXSEXOY-UHFFFAOYSA-N

物化性质

• 沸点：
  237.0±28.0 °C(Predicted)
• 密度：
  1.107±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (-)-2-pyrrolidin-3ylphenol 、 1,4-苯并二恶烷-6-甲醛 在 NaCNBH3 作用下， 以 甲醇 为溶剂， 生成 (-)-2-[1-(2,3-Dihydrobenzo[1.4]dioxin-6-ylmethyl)pyrrolidin-3-yl]phenol
  参考文献：
  名称：

  1,3 disubstituted pyrrolidines as alpha -2- adrenoceptor antagonists

  摘要：

  该发明提供了式（I）中的化合物，其中R0、R1、R2和A如描述中所定义，并提供其制备方法。式（I）中的化合物具有高亲和力作为α2肾上腺素受体，因此可用作药物。

  公开号：

  US20030008874A1

文献信息

• [EN] 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF<br/>[FR] 2-CYANOPYRROLOPYRIMIDINES ET UTILISATIONS PHARMACEUTIQUES DE CELLES-CI
  申请人：NOVARTIS AG

  公开号：WO2004069256A1

  公开（公告）日：2004-08-19

  The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents -(CH2)t-O- or -(CH2)r-S-, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is -(CH2)j- or -CH=CH-, j is 1 or 2; p is 1 or 2, or Y is -(CH2)f-, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.

  该发明涉及公式（I）中的吡咯嘧啶，其中Y代表-(CH2)t-O-或-(CH2)r-S-，p为1或2，r为1、2或3，t为1、2或3，或Y为-(CH2)j-或-CH=CH-，j为1或2；p为1或2，或Y为-(CH2)f-，f为1或2，p为1，以及进一步的基团和符号具有如本文所定义的含义；它们的制备，它们作为药物的用途，含有它们的药物组合物，利用这种化合物制备用于治疗神经病性疼痛的药物制剂的用途，以及用于治疗这种疾病的方法在动物中，尤其是在人类中。
• 4,7-dichlororhodamine dyes labeled polynucleotides
  申请人：Lee G. Linda

  公开号：US20050112781A1

  公开（公告）日：2005-05-26

  A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures wherein R 1 -R 6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, linking group, or, when taken together, R 1 and R 6 is benzo, or, when taken together, R 4 and R 5 is benzo; R 7 -R 10 , R 12 -R 16 and R 18 may be hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, linking group; R 11 and R 17 may be hydrogen, lower alkyl, lower alkene, lower alkyne, phenyl, aryl, linking group; Y 1 -Y 4 are hydrogen, lower alkyl, or cycloalkyl, or, when taken together, Y 1 and R 2 , Y 2 and R 1 Y 3 and R 3 , and/or Y 4 and R 4 is propano, ethano, or substituted forms thereof, and X 1 -X 3 taken separately are hydrogen, chlorine, fluorine, lower alkyl, carboxylate, sulfonate, hydroxymethyl, and linking group, or any combinations thereof. In another aspect, the invention includes reagents labeled with the 4,7-dichlororhodamine dye compounds, including deoxynucleotides, dideoxynucleotides, and polynucleotides. In an additional aspect, the invention includes methods utilizing such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods.

  本文披露了一组4,7-二氯罗丹明化合物的结构，可用作荧光染料，其中R1-R6为氢、氟、氯、较低烷基、较低烯烃、较低炔烃、磺酸酯、砜、氨基、酰胺、腈、较低烷氧基、连接基或在一起时，R1和R6为苯并或在一起时，R4和R5为苯并；R7-R10、R12-R16和R18可以是氢、氟、氯、较低烷基、较低烯烃、较低炔烃、磺酸酯、砜、氨基、酰胺、腈、较低烷氧基、连接基；R11和R17可以是氢、较低烷基、较低烯烃、较低炔烃、苯基、芳基、连接基；Y1-Y4可以是氢、较低烷基或环烷基，或在一起时，Y1和R2、Y2和R1、Y3和R3和/或Y4和R4为丙烷、乙烷或其取代形式，而X1-X3单独取为氢、氯、氟、较低烷基、羧酸盐、磺酸盐、羟甲基和连接基，或任何组合。在另一个方面，本发明还包括用4,7-二氯罗丹明染料化合物标记的试剂，包括脱氧核苷酸、二脱氧核苷酸和多核苷酸。在另一个方面，本发明还包括利用这种染料化合物和试剂的方法，包括二脱氧多核苷酸测序和片段分析方法。
• 2-Cyanopyrrolopyrimidines and pharmaceutical uses thereof
  申请人：Buxton Paul Francis

  公开号：US20060247251A1

  公开（公告）日：2006-11-02

  The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents —(CH 2 ) t —O— or —(CH 2 ) r —S—, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is —(CH 2 ) j — or —CH═CH—, j is 1 or 2; p is 1 or 2, or Y is —(CH 2 ) f —, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.

  本发明涉及式(I)的吡咯吡嗪化合物，其中Y代表—(CH2)t—O—或—(CH2)r—S—，p为1或2，r为1、2或3，t为1、2或3，或Y为—(CH2)j—或—CH═CH—，j为1或2；p为1或2，或Y为—(CH2)f—，f为1或2，p为1，其余基团和符号的含义如本文所定义；制备它们，将它们用作药物，含有它们的制药组合物，使用这种化合物制备治疗神经病痛的药物制剂以及治疗这种疾病的方法，尤其是在动物，特别是人类中。
• 4,7-DICHLORORHODAMINE DYES
  申请人：Lee Linda G.

  公开号：US20090093623A1

  公开（公告）日：2009-04-09

  A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures wherein R 1 -R 6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, linking group, or, when taken together, R 1 and R 6 is benzo, or, when taken together, R 4 and R 5 is benzo; R 7 -R 10 , R 12 -R 16 and R 18 may be hydrogen, fluorine, chlorine, lower alkyl lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, linking group; R 11 and R 17 may be hydrogen, lower alkyl lower alkene, lower alkyne, phenyl, aryl, linking group; Y 1 -Y 4 are hydrogen, lower alkyl or cycloalkyl, or, when taken together, Y 1 and R 2 , Y 2 and R 1 Y 3 and R 3 , and/or Y 4 and R 4 is propano, ethano, or substituted forms thereof, and X 1 -X 3 taken separately are hydrogen, chlorine, fluorine, lower alkyl, carboxylate, sulfonate, hydroxymethyl, and linking group, or any combinations thereof. In another aspect, the invention includes reagents labeled with the 4,7-dichlororhodamine dye compounds, including deoxynucleotides, dideoxynucleotides, and polynucleotides. In an additional aspect, the invention includes methods utilizing such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods.

  披露了一组有用的荧光染料的4,7-二氯罗丹明化合物，具有以下结构式，其中R1-R6是氢、氟、氯、低烷基、低烯烃、低炔烃、磺酸盐、磺酮、氨基、酰胺、腈、低烷氧基、连接基或当一起取时，R1和R6是苯并或当一起取时，R4和R5是苯并；R7-R10、R12-R16和R18可以是氢、氟、氯、低烷基、低烯烃、低炔烃、磺酸盐、磺酮、氨基、酰胺、腈、低烷氧基、连接基；R11和R17可以是氢、低烷基、低烯烃、低炔烃、苯基、芳基、连接基；Y1-Y4可以是氢、低烷基或环烷基，或当一起取时，Y1和R2、Y2和R1、Y3和R3、和/或Y4和R4是丙烷基、乙烷基或其取代形式，X1-X3分别取氢、氯、氟、低烷基、羧酸盐、磺酸盐、羟甲基和连接基或其任意组合。在另一个方面，本发明包括标记有4,7-二氯罗丹明染料化合物的试剂，包括脱氧核苷酸、二脱氧核苷酸和多核苷酸。在另一个方面，本发明包括利用这种染料化合物和试剂的方法，包括二脱氧多核苷酸测序和片段分析方法。
• MODULATORS OF SEROTONIN RECEPTOR
  申请人：Carruthers Nicholas I.

  公开号：US20110207709A1

  公开（公告）日：2011-08-25

  Certain biphenyl compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

  某些联苯化合物是有效的血清素调节剂，可用于治疗血清素介导的疾病。