4'-{3-[(3R)-3-aminopyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrile | 392337-21-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-{3-[(3R)-3-aminopyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrile
• 英文别名: 4-[4-[3-[(3R)-3-aminopyrrolidin-1-yl]propoxy]phenyl]benzonitrile
• CAS: 392337-21-2
• 化学式: C₂₀H₂₃N₃O
• 分子量: 321.422
• InChiKey: RRBSCZCNYAJFEJ-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  62.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-3-吡咯烷醇 、 4'-{3-[(3R)-3-aminopyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrile 在 potassium iodide 、 potassium carbonate 作用下， 以 丁酮 为溶剂， 以61%的产率得到4'-{3-[(3S)-3-hydroxypyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrile
  参考文献：
  名称：

  1,3-Disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications

  摘要：

  公式I1的化合物在治疗由组织胺-3受体配体防止或改善的疾病或病况中非常有用。还公开了组织胺-3受体配体组合物和拮抗或激动组织胺-3受体的方法。

  公开号：

  US20020035103A1
• 作为产物：
  描述：

  氰基联苯酚 在 potassium carbonate 、 potassium iodide 作用下， 以 丁酮 为溶剂， 反应 96.0h， 生成 4'-{3-[(3R)-3-aminopyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrile
  参考文献：
  名称：

  Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands

  摘要：

  Biaryl nitrile amines were prepared and found to have high affinity and selectivity for human and rat histamine H-3 receptors. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00648-0

文献信息

• 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
  申请人：——

  公开号：US20020137931A1

  公开（公告）日：2002-09-26

  Compounds of formula I 1 are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.

  公式I1的化合物在治疗由组胺-3受体配体防止或改善的疾病或症状中很有用。还披露了组胺-3受体配体组合物和拮抗或激动组胺-3受体的方法。
• [EN] 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS<br/>[FR] PYRROLIDINES 1,3-DISUBSTITUEES ET 1,3,3-TRISUBSTITUEES UTILISEES COMME LIGANDS DU RECEPTEUR DE L'HISTAMINE-3 ET LEURS APPLICATIONS THERAPEUTIQUES
  申请人：ABBOTT LAB

  公开号：WO2002006223A1

  公开（公告）日：2002-01-24

  Compounds of formula (I) are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.

  I式化合物可用于治疗由组胺-3受体配体预防或改善的疾病或症状。还公开了组胺-3受体配体组合物以及拮抗或激动组胺-3受体的方法。
• [EN] 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS<br/>[FR] PYRROLIDINES 1,3-DISUBSTITUEES ET 1,3,3,-TRISUBSTITUEES UTILISEES COMME LIGANDS DU RECEPTEUR DE L'HISTAMINE-3 ET APPLICATIONS THERAPEUTIQUES
  申请人：ABBOTT LAB

  公开号：WO2003059341A1

  公开（公告）日：2003-07-24

  Compounds of formula I, are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.

  式I的化合物可用于治疗由组胺-3受体配体预防或改善的疾病或病况。本发明还揭示了组胺-3受体配体组合物和拮抗或激动组胺-3受体的方法。
• 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS
  申请人：ABBOTT LABORATORIES

  公开号：EP1301480A1

  公开（公告）日：2003-04-16
• 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS
  申请人：Abbott Laboratories

  公开号：EP1467727A1

  公开（公告）日：2004-10-20