| 1314716-36-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1314716-36-3
• 化学式: C₁₈H₂₇BrO₃
• 分子量: 371.315
• InChiKey: BCVDRBNGKKPBGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  22.0
• 可旋转键数：
  13.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  在 rhodium(II) acetate dimer 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 生成
  参考文献：
  名称：

  Diastereoselective synthesis of macrocycles incorporating the spiro-indolofurans and -indolodioxolanes

  摘要：

  Generation of intramolecular macrocyclic carbonyl ylides from aldehyde group tethered to diazoamides in the presence of rhodium(II) acetate and their successful [3+2]-cycloaddition afforded the corresponding macrocycles incorporating spiro-indolofurans, -indolofuropyrroles, -indolofurofurans, and -indolodioxolanes in moderate to good yield with complete diastereoselectivity. The competition between the electrocyclization and [3+2]-cycloaddition reactions of macrocyclic carbonyl ylides was also demonstrated. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.12.020
• 作为产物：
  描述：

  2-羟基-4-甲氧基苯甲醛 、 1,10-二溴癸烷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Diastereoselective synthesis of macrocycles incorporating the spiro-indolofurans and -indolodioxolanes

  摘要：

  Generation of intramolecular macrocyclic carbonyl ylides from aldehyde group tethered to diazoamides in the presence of rhodium(II) acetate and their successful [3+2]-cycloaddition afforded the corresponding macrocycles incorporating spiro-indolofurans, -indolofuropyrroles, -indolofurofurans, and -indolodioxolanes in moderate to good yield with complete diastereoselectivity. The competition between the electrocyclization and [3+2]-cycloaddition reactions of macrocyclic carbonyl ylides was also demonstrated. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.12.020

文献信息

• Rhodium(<scp>ii</scp>) catalyzed synthesis of macrocycles incorporating oxindole via O–H/N–H insertion reactions
  作者：Sengodagounder Muthusamy、Thangaraju Karikalan

  DOI：10.1039/c4ob01671h

  日期：——

  an oxindole unit were synthesized in good yield via rhodium(II) acetate dimer catalyzed intramolecular O–H/N–H insertion reactions. Interestingly, synthesis of C2-symmetric macrocycles in moderate yield was also demonstrated via head to tail dimerization involving double intermolecular O–H insertion when the spacer length was decreased. The synthesis of chiral macrocycles was also delineated. This study

  通过乙酸铑（II）二聚体催化的分子内OH / N-H插入反应，可以高收率合成各种结合有吲哚单元的10到29元的氧杂氮杂大环。有趣的是，当间隔区长度减小时，通过头到尾二聚作用也涉及到了双分子间OH插入，从而证明了C 2对称大环化合物以中等产率合成。还描述了手性大环的合成。这项研究揭示了间隔物长度对与远程羟基/氨基的分子间或分子内插入反应的影响。