cannabichromevarinic acid | 64898-02-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cannabichromevarinic acid
• 英文别名: CBCVA；5-hydroxy-2-methyl-2-(4-methyl-pent-3-enyl)-7-propyl-2H-chromene-6-carboxylic acid；5-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-7-propylchromene-6-carboxylic acid
• CAS: 64898-02-8
• 化学式: C₂₀H₂₆O₄
• 分子量: 330.424
• InChiKey: OIVPAQDCMDYIIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-3,7-二甲基-2,6-辛二烯醛 在 calcium hydroxide 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 144.0h， 生成 cannabichromevarinic acid
  参考文献：
  名称：

  钙试剂对酒精中酚类烯醇化物与醛类醛醇醛缩醛反应的影响。

  摘要：

  DOI：

  10.1021/jo961352k

文献信息

• [EN] SYNTHESIS OF PHYTOCANNABINOIDS INCLUDING A DEMETHYLATION STEP<br/>[FR] SYNTHÈSE DE PHYTOCANNABINOÏDES COMPRENANT UNE ÉTAPE DE DÉMÉTHYLATION
  申请人：UNIV SYDNEY

  公开号：WO2019033164A1

  公开（公告）日：2019-02-21

  A method for demethylating a methylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: Formula I Formula II wherein: R1 is selected from the group consisting of: substituted or unsubstituted C1-C5 alkyl; R2 is selected from the group consisting of: OH or O, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C2-C8 alkene, or a substituted or unsubstituted C2-C8 dialkene; or R2 is O, and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes: heating a reaction mixture comprising the methylated phytocannabinoid compounds and a polar aprotic solvent in the presence of a dissolved inorganic alkaline salt for a time sufficient to demethylate at least a portion of the methylated phytocannabinoid compounds and form the phytocannabinoid compound.

  一种去甲基化甲基化植物大麻化合物的方法，形成化学式II的植物大麻化合物：化学式I 化学式II 其中：R1选择自：取代或未取代的C1-C5烷基；R2选择自：OH或O，并且R3选择自：取代或未取代的环己烯，取代或未取代的C2-C8烯烃，或取代或未取代的C2-C8双烯；或者R2为O，且R2和R3一起形成一个环结构，其中R2为内环原子；其中该方法包括：在存在溶解的无机碱性盐的极性无水溶剂中加热反应混合物，以足够时间去甲基化至少一部分甲基化植物大麻化合物并形成植物大麻化合物。
• Breeding, production, processing and use of medical cannabis
  申请人：BIOTECH INSTITUTE, LLC

  公开号：US10441617B2

  公开（公告）日：2019-10-15

  The invention provides compositions and methods for the breeding, production, processing and use of medical cannabis.

  本发明提供了用于培育、生产、加工和使用医用大麻的组合物和方法。
• Apparatus and methods for sample analysis and classification based on terpenes and cannabinoids in the sample
  申请人：Biotech Institute, LLC

  公开号：US10830780B2

  公开（公告）日：2020-11-10

  The disclosure relates to systems, apparatuses, and methods for estimating a terpene level of two or more terpenes of the plurality of terpenes in the sample to generate a set of terpene levels; and/or estimating a cannabinoid level of two or more cannabinoids of the plurality of cannabinoids in the sample to generate a set of cannabinoid levels; configured to store a set of groups and classify the sample to a group of the set of groups, based on said terpene and cannabinoid levels. The present disclosure also relates to systems, apparatuses, and methods configured to generate entourage effect values and organoleptic values, based on said cannabinoid and terpene levels.

  本公开涉及系统、装置和方法，用于估算样品中多种萜烯中两种或多种萜烯的萜烯含量，以生成一组萜烯含量；和/或估算样品中多种大麻素中两种或多种大麻素的大麻素含量，以生成一组大麻素含量；根据所述萜烯和大麻素含量，配置为存储一组组别并将样品分类到组别中的一组。本公开还涉及根据所述大麻素和萜烯含量生成随附效应值和感官值的系统、装置和方法。
• Biosynthesis of cannabinoids and cannabinoid precursors
  申请人：Ginkgo Bioworks, Inc.

  公开号：US11274320B2

  公开（公告）日：2022-03-15

  Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.

  本公开的各个方面涉及在重组细胞和体外进行大麻素和大麻素前体的生物合成。
• Methods and compositions for treating cancer
  申请人：Sutter West Bay Hospitals

  公开号：US11344527B2

  公开（公告）日：2022-05-31

  This disclosure provides compositions and method useful for treating cell proliferative disorders including cancer. The disclosure provides cannabidiol derivatives and compositions thereof either alone or in combination with THC or a derivative thereof.

  本公开提供了用于治疗包括癌症在内的细胞增殖性疾病的组合物和方法。本公开提供了大麻二酚衍生物及其单独或与四氢大麻酚或其衍生物结合使用的组合物。