4-chloro-benzenethiosulfonic acid ; potassium-salt | 42546-07-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-benzenethiosulfonic acid ; potassium-salt
• 英文别名: 4-Chlor-benzolthiosulfonsaeure; Kalium-Salz；Potassium;(4-chlorophenyl)-oxido-oxo-sulfanylidene-lambda6-sulfane；potassium;(4-chlorophenyl)-oxido-oxo-sulfanylidene-λ6-sulfane
• CAS: 42546-07-6
• 化学式: C₆H₄ClO₂S₂*K
• 分子量: 246.78
• InChiKey: HVBBKJNJUNOJPF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.42
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-chloro-benzenethiosulfonic acid ; potassium-salt 、 4-chloro-benzenesulfenyl chloride 以 乙醚 为溶剂， 生成 4,4'-dichlorophenyl thiosulfonate
  参考文献：
  名称：

  Organic sulfur chemistry. 33. Chemistry of sulfenic sulfonic thioanhydrides. Solvent-dependent sulfur extrusion

  摘要：

  DOI：

  10.1021/jo01337a025

文献信息

• Hypervalent Iodine in Synthesis XXII: A Novel Way for the Preparation of Unsymmetric S-Aryl Thiosulfonates by the Reaction of Potassium Thiosulfonates with Diaryliodonium Salts
  作者：Min Xia、Zhen-Chu Chen

  DOI：10.1080/00397919708006058

  日期：1997.4

  Abstract Unsymmetric S-aryl thiosulfonates can be generated through a novel way for the reaction of potassium thiosulfonates with diaryliodonium salts in good yields under mild conditions.

  摘要 硫代磺酸钾与二芳基碘鎓盐在温和条件下以良好的收率反应，可以通过一种新的方法制备不对称的硫代磺酸S-芳基酯。
• CHIRAL CONTROL
  申请人：WAVE LIFE SCIENCES PTE. LTD.

  公开号：US20150211006A1

  公开（公告）日：2015-07-30

  The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

  本发明涉及手性控制的寡核苷酸、手性控制的寡核苷酸组合物以及其制备和使用方法。本发明特别涵盖了鉴定以前制备手性寡核苷酸方法中某些问题的来源，包括禁止制备完全手性控制的组合物，特别是包含多种寡核苷酸类型的组合物。在某些实施例中，本发明提供了手性控制的寡核苷酸组合物。在某些实施例中，本发明提供了制备手性控制的寡核苷酸和手性控制的寡核苷酸组合物的方法。
• Chiral control
  申请人：WAVE LIFE SCIENCES LTD.

  公开号：US10590413B2

  公开（公告）日：2020-03-17

  The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

  本发明涉及手性受控寡核苷酸、手性受控寡核苷酸组合物以及制作和使用方法。本发明具体包括确定先前制备手性寡核苷酸方法中某些问题的根源，包括禁止制备完全手性控制的组合物，特别是包含多种寡核苷酸类型的组合物的问题。在某些实施方案中，本发明提供了手性控制的寡核苷酸组合物。在一些实施方案中，本发明提供了制作手性控制寡核苷酸和手性控制寡核苷酸组合物的方法。
• Boldyrev,B.G. et al., Journal of general chemistry of the USSR, 1961, vol. 31, p. 2238 - 2241
  作者：Boldyrev,B.G. et al.

  DOI：——

  日期：——
• BILOZOR, T. K., XIMIYA FIZIOL. AKTIV. SOED., CHERNOGOLOVKA,(1989) S. 38
  作者：BILOZOR, T. K.

  DOI：——

  日期：——