Ethyl 2-[[5-(5-amino-3,4-diphenylthieno[2,3-c]pyridazin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Ethyl 2-[[5-(5-amino-3,4-diphenylthieno[2,3-c]pyridazin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate
• 化学式: C₂₄H₁₉N₅O₃S₂
• 分子量: 489.579
• InChiKey: SLWCLFGEHFYZRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  171
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  3-amino-4,5-diphenylthieno[2,3-c]pyridazine-2-carbohydrazide 在 吡啶 、 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 9.0h， 生成 Ethyl 2-[[5-(5-amino-3,4-diphenylthieno[2,3-c]pyridazin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate
  参考文献：
  名称：

  SYNTHESIS OF PYRIDAZOTHIENOTHIAZINE AND PYRIMIDOTHIENOPYRIDAZINES

  摘要：

  3-amino-4,5-diphenylthieno[2, 3-c]pyridazine-2-arylcarboxamide 2 underwent cyclization with triethyl orthoformate and with nitrous acid to give the pyrimidothienopyridazines 3a-c, 4b respectively. 3-amino-4,5-diphenylthieno [2,3-c] pyridazine-2-carbohydrazide 6 reacted with aromatic aldehydes to give;the corresponding carbohydrazones 7a-c. Compound 7 reacts with triethyl orthoformate, acetic anhydride or with CS2/pyridine to produce pyrimidothienopyridazines 8,9 and pyridazothienothiazine 11.

  DOI：

  10.1080/10426500008045255

文献信息

• SYNTHESIS OF PYRIDAZOTHIENOTHIAZINE AND PYRIMIDOTHIENOPYRIDAZINES
  作者：Sh. M. Radwan、A. M. Kamal El-Dean

  DOI：10.1080/10426500008045255

  日期：2000.1

  3-amino-4,5-diphenylthieno[2, 3-c]pyridazine-2-arylcarboxamide 2 underwent cyclization with triethyl orthoformate and with nitrous acid to give the pyrimidothienopyridazines 3a-c, 4b respectively. 3-amino-4,5-diphenylthieno [2,3-c] pyridazine-2-carbohydrazide 6 reacted with aromatic aldehydes to give;the corresponding carbohydrazones 7a-c. Compound 7 reacts with triethyl orthoformate, acetic anhydride or with CS2/pyridine to produce pyrimidothienopyridazines 8,9 and pyridazothienothiazine 11.