3-(β-D-ribofuranosyl)uracil | 6745-33-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 3-(β-D-ribofuranosyl)uracil
• 英文别名: 3-beta-D-Ribofuranosyluracil；3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidine-2,4-dione
• CAS: 6745-33-1
• 化学式: C₉H₁₂N₂O₆
• 分子量: 244.204
• InChiKey: NBNBAENCKIJZAH-XVFCMESISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-(β-D-ribofuranosyl)uracil 在 吡啶 、 silver nitrate 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 14.0h， 生成 3-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
  参考文献：
  名称：

  [EN] COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF
  [FR] COMPOSITIONS POUR L'ÉDITION DE TRANSCRITS MECP2 ET PROCÉDÉS ASSOCIÉS

  摘要：

  Among other things, the present disclosure provides oligonucleotides, compositions and methods thereof that can bring about specific editing of a target adenosine in a target RNA molecule. Such oligonucleotides, compositions and methods are useful to treat, prevent, or ameliorate MECP2 associated disorders, diseases and syndromes that can benefit from adenosine modification.

  公开号：

  WO2023049477A2
• 作为产物：
  描述：

  6-chloro-1-(2',3'-O-isopropylidene-β-D-ribofuranosyl)-O6,5'-cyclo-1,2,3,6-tetrahydropyrimidin-2-one 在 sodium hydroxide 、 cation exchage resin 50W-X₈ 作用下， 以 水 为溶剂， 反应 37.0h， 生成 3-(β-D-ribofuranosyl)uracil
  参考文献：
  名称：

  Rao, Kambhampati V. B.; Marquez, Victor E.; Kelley, James A., Journal of the Chemical Society. Perkin transactions I, 1983, # 1, p. 127 - 130

  摘要：

  DOI：

文献信息

• 5-Fluorouracil derivatives. Vii. Tert-amine promoted n-glycosidation of pyrimidines
  作者：Shoichiro Ozaki、Yutaka Watanabe、Tomonori Hoshiko、Hiroshi Fujisawa、Atsuhiko Uemura、Kazuhiko Ohrai

  DOI：10.1016/s0040-4039(01)91119-0

  日期：1984.1

  Acylglycosyl halides react smoothly with N1 - and N3-(octylthio)-carbonylpyrimidines in the presence of tert-amine to give the corresponding nucleosides in good yields.

  酰基糖基卤化物在叔胺存在下与N 1-和N 3-（辛硫基）-羰基嘧啶平稳反应，以高收率得到相应的核苷。
• Compounds comprising disulfide-containing peptides and nitrogenous bases, and medical uses thereof
  申请人：——

  公开号：US20030073618A1

  公开（公告）日：2003-04-17

  The invention relates to new compositions and medical uses, such as anti-infectious pharmacology. The compositions include salts and compounds of GSSG including a nitrogenous base comprising one or more of DNA bases, nucleosides of DNA bases, nucleotides of DNA bases, RNA bases, nucleosides of RNA bases, nucleotides of RNA bases, inosine, nucleotides of inosine, and homologues, analogues and derivatives thereof. The invention is also directed to methods for treatment and prevention of infectious diseases such as viral hepatitis B and C, AIDS and herpes.

  本发明涉及新的组合物和医疗用途，如抗感染药理学。这些组合物包括 GSSG 的盐和化合物，其中包括含氮碱基，包括 DNA 碱基、DNA 碱基的核苷、DNA 碱基的核苷酸、RNA 碱基、RNA 碱基的核苷酸、RNA 碱基的核苷酸、肌苷、肌苷的核苷酸以及它们的同系物、类似物和衍生物中的一种或多种。本发明还涉及治疗和预防乙型和丙型病毒性肝炎、艾滋病和疱疹等传染性疾病的方法。
• Kavunenko, Antonina P.; Holy, Antonin, Collection of Czechoslovak Chemical Communications, 1980, vol. 45, # 2, p. 611 - 616
  作者：Kavunenko, Antonina P.、Holy, Antonin

  DOI：——

  日期：——
• COMPOUNDS COMPRISING DISULFIDE-CONTAINING PEPTIDES AND NITROGENOUS BASES, AND MEDICAL USES THEREOF
  申请人：Novelos Therapeutics, Inc.

  公开号：EP1365789A1

  公开（公告）日：2003-12-03
• [EN] COMPOUNDS COMPRISING DISULFIDE-CONTAINING PEPTIDES AND NITROGENOUS BASES, AND MEDICAL USES THEREOF<br/>[FR] COMPOSES COMPRENANT DES PEPTIDES CONTENANT DU BISULFURE ET DES BASES AZOTEES ET UTILISATION MEDICALE DE CEUX-CI
  申请人：NOVELOS THERAPEUTICS INC

  公开号：WO2002076490A1

  公开（公告）日：2002-10-03

  The invention relates to new compositions and medical uses, such as anti-infectious pharmacology. The compositions include salts and compounds of GSSG including at least one counterion comprising a nitrogenous base. Examples of such nitrogenous bases include DNA bases, nucleosides of DNA bases, nucleotides of DNA bases, RNA bases, nucleosides of RNA bases, nucleotides of RNA bases, inosine, nucleotides of inosine, and homologues, analogues and derivatives thereof. The invention is also directed to methods for treatment and prevention of infectious diseases such as viral hepatitis B and C, AIDS and herpes.