7-Oxo-2,4-dimethyl-5,6,7,8-tetrahydro-pyrido<2,3-d>pyrimidin | 145733-63-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 7-Oxo-2,4-dimethyl-5,6,7,8-tetrahydro-pyrido<2,3-d>pyrimidin
• 英文别名: 2,4-dimethyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one；2,4-dimethyl-5,6,8-trihydro-7H-pyrido[2,3-d]pyrimidin-7-one；2,4-Dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one；2,4-dimethyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
• CAS: 145733-63-7
• 化学式: C₉H₁₁N₃O
• 分子量: 177.206
• InChiKey: CXVCPPQCXTUFQC-UHFFFAOYSA-N

物化性质

• 沸点：
  308.3±35.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-Oxo-2,4-dimethyl-5,6,7,8-tetrahydro-pyrido<2,3-d>pyrimidin 在 碘代三甲硅烷 、 sodium hydride 作用下， 以 二氯甲烷 为溶剂， 反应 42.5h， 生成 4'-<(2,4-dimethyl-7-oxo-6,7-dihydro-5H-pyrido<2,3-d>pyrimidin-8-yl)methyl>biphenyl-2-carboxylic acid
  参考文献：
  名称：

  Pyrido[2,3-d]pyrimidine Angiotensin II Antagonists

  摘要：

  A series of pyrido[2,3-d]pyrimidine angiotensin II (A II) antagonists was synthesized and tested for antagonism of A II. Compounds with a biphenylyltetrazole pharmacophore and small alkyl groups at the 2- and ii-positions Of the pyridopyrimidine ring were found to be the most potent in an AT(1) receptor binding assay and in blocking the A II presser response in anesthetized, ganglion-blocked A II-infused rats. 5,8-Dihydro-2,4-dimethyl-8-[(2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl)methyl] pyrido[2,3-d]pyrimidin-7(6H)-one (4a) was one of the more potent compounds in the binding assay and was the most efficacious compound in the A II-infused rat model. Further study of 4a;in Goldblatt (2K-1C) rats showed the compound to have oral bioavailability and to be an efficacious and potent compound in a high renin form of hypertension.

  DOI：

  10.1021/jm00030a013
• 作为产物：
  描述：

  ethyl 3-(4-chloro-2,6-dimethylpyrimidin-5-yl)propionate 在 氨 作用下， 以 乙醇 、 水 为溶剂， 以14.9 g (76%)的产率得到7-Oxo-2,4-dimethyl-5,6,7,8-tetrahydro-pyrido<2,3-d>pyrimidin
  参考文献：
  名称：

  Substituted pyridopyrimidines useful as antgiotensin II antagonists

  摘要：

  本发明涉及一般式I的吡咯基、吡啶基、氮杂七元环和氮杂环丙嘧啶类化合物，对治疗高血压和充血性心力衰竭有用，还涉及制药组合物及其生产方法。

  公开号：

  US05149699A1

文献信息

• Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：US10702521B2

  公开（公告）日：2020-07-07

  The present invention relates to methods for treating Neisseria Gonorrhoeae infection which comprises administering to a subject in need thereof novel 1,2-dihydro-2a,5,8a-triazaacenaphthylene-3,8-dione compounds: or pharmaceutically acceptable salts thereof and/or corresponding pharmaceutical compositions.

  本发明涉及治疗淋病双球菌感染的方法，包括向需要的受试者施用新型1,2-二氢-2a,5,8a-三氮杂蒽-3,8-二酮化合物：或其药学上可接受的盐和/或相应的药物组合物。
• Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines
  申请人：American Home Products Corporation

  公开号：US05256654A1

  公开（公告）日：1993-10-26

  This invention relates to pyrrolo-, pyrido-, azepino-, and azocinopyrimidines of the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently H, lower alkyl containing 1 to 6 carbon atoms, or perfluoroalkyl containing 1 to 6 carbon atoms; R.sup.5 is H or when n is 1 R.sup.5 taken together with R.sup.3 comprises a double bond; n is 0 to 1; p is 0 to 2; m is 0 to 3; Ar.sup.1 is ##STR2## wherein W is H, lower alkyl containing 1 to 6 carbon atoms, halogen, hydroxy, or lower alkoxy containing 1 to 6 carbon atoms; Ar.sup.2 is ##STR3## wherein X is ##STR4## wherein R.sup.6 is H, tert-butyl, tri-n-butylstannyl, or triphenylmethyl; and the pharmaceutically acceptable salts thereof which by virtue of their ability to antagonize angiotensin II are useful for the treatment of hypertension, congestive heart failure, and restenosis. The compounds are also useful for reducing lipid levels in the blood plasma and are thus useful for treating hyperlipidemia and hypercholesterolemia. Also disclosed are processes for the production of said compounds and pharmaceutical compositions containing said compounds.

  这项发明涉及一般式I的吡咯烯、吡啶烯、氮杂七元环和氮杂七元杂环嘧啶类化合物，其中R.sup.1、R.sup.2、R.sup.3和R.sup.4分别独立地为H、含有1至6个碳原子的较低烷基，或含有1至6个碳原子的全氟烷基；R.sup.5为H，当n为1时，R.sup.5与R.sup.3一起构成双键；n为0至1；p为0至2；m为0至3；Ar.sup.1为##STR2##其中W为H、含有1至6个碳原子的较低烷基、卤素、羟基或含有1至6个碳原子的较低烷氧基；Ar.sup.2为##STR3##其中X为##STR4##其中R.sup.6为H、叔丁基、三正丁基锡基或三苯甲基；以及它们的药用可接受盐，由于它们具有拮抗血管紧张素II的能力，因此可用于治疗高血压、充血性心力衰竭和再狭窄。这些化合物还可用于降低血浆中的脂质水平，因此可用于治疗高脂血症和高胆固醇血症。还公开了生产这些化合物的方法和含有这些化合物的药物组合物。
• [EN] TRICYCLIC NITROGEN COMPOUNDS USED AS ANTIBACTERIALS<br/>[FR] COMPOSÉS AZOTÉS TRICYCLIQUES UTILISÉS COMME AGENTS ANTIBACTÉRIENS
  申请人：GLAXO GROUP LTD

  公开号：WO2010043714A1

  公开（公告）日：2010-04-22

  Tricyclic nitrogen containing compounds (I) and their use as antibacterials.

  三环氮含有化合物（I）及其作为抗菌剂的用途。
• [EN] TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION<br/>[FR] COMPOSÉS CONTENANT DE L'AZOTE TRICYCLIQUE POUR LE TRAITEMENT DE L'INFECTION À NEISSERIA GONORRHOEAE
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2016027249A1

  公开（公告）日：2016-02-25

  The present invention relates to methods for treating Neisseria gonorrhoeae infection which comprises administering to a subject in need thereof novel Tricyclic nitrogen containing compounds and corresponding pharmaceutical compositions as described herein.

  本发明涉及一种治疗淋病奈瑟氏菌感染的方法，包括向需要该方法的受试者施用本文所述的新型三环氮含量化合物及相应的药物组成。
• Condensed pyrimidine derivatives and their use as angiotensine II antagonists
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0539086A2

  公开（公告）日：1993-04-28

  This invention relates to pyrrolo-, pyrido-, azepino-, and azocinopyrimidines of the general formula I useful for treating hypertension or congestive heart failure and for preventing or treating restenosis following angioplasty, to pharmaceutical compositions, and to methods for production thereof.

  本发明涉及通式 I 的吡咯并嘧啶、吡啶并嘧啶、氮杂环庚并嘧啶和氮杂环辛并嘧啶。 用于治疗高血压或充血性心力衰竭以及预防或治疗血管成形术后的再狭窄、药物组合物及其生产方法。