2-[(1-Oxopentyl)amino]benzamide | 150422-54-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(1-Oxopentyl)amino]benzamide
• 英文别名: 2-(pentanoylamino)benzamide
• CAS: 150422-54-1
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: WUKFJWGQJIEEEN-UHFFFAOYSA-N

物化性质

• 沸点：
  450.6±28.0 °C(Predicted)
• 密度：
  1.154±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(1-Oxopentyl)amino]benzamide 在 sodium hydroxide 作用下， 生成 2-butylquinazolin-4(3H)-one
  参考文献：
  名称：

  Phosphodiesterase inhibitory properties of losartan. design and synthesis of new lead compounds

  摘要：

  A 4-centre PDE 4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developping PDE 4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00058-4
• 作为产物：
  描述：

  戊酸酐 在 ammonium hydroxide 作用下， 生成 2-[(1-Oxopentyl)amino]benzamide
  参考文献：
  名称：

  Phosphodiesterase inhibitory properties of losartan. design and synthesis of new lead compounds

  摘要：

  A 4-centre PDE 4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developping PDE 4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00058-4

文献信息

• Indole and benzimidazole-substituted dihydropyrimidine derivatives
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US05212177A1

  公开（公告）日：1993-05-18

  Novel compounds having the formula ##STR1## and its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, an antihypertensive agents.

  具有以下结构式的新化合物##STR1##及其异构体##STR2##其中R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5、R.sub.6、R.sub.7和X的定义如本文所述。这些化合物抑制血管紧张素II的作用，因此可用作例如降压药。
• Dihydropyrimidine derivatives
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US05350752A1

  公开（公告）日：1994-09-27

  Novel A-II receptor antagonists have the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6, are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.

  新型A-II受体拮抗剂的化学式为##STR1##或其异构体##STR2##，其中R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5和R.sub.6的定义如本文所述。这些化合物抑制肾素-血管紧张素II的作用，因此例如可用作降压药。
• Chemical Compounds-149
  申请人：Aquila Brian

  公开号：US20080312206A1

  公开（公告）日：2008-12-18

  The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

  本发明涉及一种化合物，或其药学上可接受的盐，其化学式如下，具有CSF 1R激酶抑制活性，因此在抗癌活性方面有用，并且在人或动物体的治疗方法中有用。本发明还涉及制造所述化合物的过程，含有它们的制药组合物以及它们在制造用于在温血动物（如人）中产生抗癌效果的药物中的使用。
• Dihydropyrimidin derivatives used as A-II receptor antagonists
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0547442A1

  公开（公告）日：1993-06-23

  Novel A-II receptor antagonists have the formula or its isomer wherein R₁, R₂, R₃, R₄, R₅, and R₆, are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.

  新型 A-II 受体拮抗剂的化学式为 或其异构体 其中 R₁、R₂、R₃、R₄、R₅ 和 R₆ 如本文所定义。这些化合物可抑制血管紧张素 II 的作用，因此可用作降压药等。
• Substituted indole and benzimidazole derivatives useful as A-II receptors antagonists
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0547556A1

  公开（公告）日：1993-06-23

  Novel compounds are disclosed having the formula or its isomer wherein R₁, R₂, R₃, R₄, R₅, R₆, R₇ and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.

  公开了具有以下式子的新型化合物 或其异构体 其中 R₁、R₂、R₃、R₄、R₅、R₆、R₇ 和 X 如本文所定义。这些化合物可抑制血管紧张素 II 的作用，因此可用作降压药等。