ammonium benzoate | 102806-34-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ammonium benzoate
• 英文别名: Azane;phenylmethanol
• CAS: 102806-34-8
• 化学式: C₇H₈O*H₃N
• 分子量: 125.17
• InChiKey: YYTGOTUOUTUALN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.34
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-epoxyhexanol 、 ammonium benzoate 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 3-phenylmethoxyhexane-1,2-diol 、
  参考文献：
  名称：

  Choudary, B.M.; Rani, S. Shobha; Kantam, M. Lakshmi, Synthetic Communications, 1990, vol. 20, # 15, p. 2313 - 2317

  摘要：

  DOI：

文献信息

• PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS
  申请人：Pfeifer Lance Allen

  公开号：US20100099725A1

  公开（公告）日：2010-04-22

  The present invention is directed to compounds of the structural Formula: wherein: R 1 is H or —C 1 -C 3 alkyl; R 2 is selected from the group consisting of —H, —C 1 -C 4 alkyl, —C 1 -C 3 alkyl-CF 3 , phenyl, and pyridinyl; and R 3 is selected from the group consisting of —H, —C 1 -C 4 alkyl, —C 1 -C 3 alkyl-O—CH 3 , —CH 2 -cyclopropyl, CH 2 —C═CH 2 , —CH 2 CH 2 -(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; provided that when R 1 and R 2 are each H, then R 3 is selected from the group consisting of —C 1 -C 4 alkyl, —C 1 -C 3 alkyl-O—CH 3 , —CH 2 -cyclopropyl, —CH 2 —C═CH 2 , —CH 2 CH 2 -(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; or stereoisomers and pharmaceutically acceptable salts thereof.

  本发明涉及结构式的化合物：其中：R1为H或-C1-C3烷基；R2选择自-H、-C1-C4烷基、-C1-C3烷基-CF3、苯基和吡啶基的组合；R3选择自-H、-C1-C4烷基、-C1-C3烷基-O-CH3、-CH2-环丙基、CH2-C═CH2、-CH2CH2-(2-F-苯基)和1至2个氟原子取代的苯基；但当R1和R2都为H时，R3选择自-C1-C4烷基、-C1-C3烷基-O-CH3、-CH2-环丙基、-CH2-C═CH2、-CH2CH2-(2-F-苯基)和1至2个氟原子取代的苯基；或其立体异构体和药学上可接受的盐。
• Ash-free multivalent cationstable dispersants for inorganic powders
  申请人：THE B.F. GOODRICH COMPANY

  公开号：EP0260577A1

  公开（公告）日：1988-03-23

  The present invention resides in certain at least partially neutralized carboxylated acrylic polymers that are active dispersants for inorganic and metallic powders in aqueous vehicles. These carboxylated acrylic polymers are at least partially neutralized with quaternary organic ammonium hydroxides. In one embodiment, such a neutralized carboxylated acrylic polymer comprises a water-soluble polymer having an acrylic backbone and carboxyl groups disposed at spaced locations along the backbone. This polymer is at least partially neutralized with a water-soluble quaternary organic ammonium hydroxide that neutralizes at least some of the carboxyl groups. The neutralized polymer is useful in dispersing in an aqueous medium a powder that can release into the aqueous medium one or more multivalent metal cations. The neutralized polymer is stable in solution against precipitation as a metal-polymer complex, at a concentration in the aqueous medium of multivalent cation released from said powder into the aqueous medium, and a concentration of dispersant polymer sufficient to effect dispersion of the inorganic powder. The invention further resides in the use of such polymeric materials as dispersants, in aqueous formulations and compositions containing them, and in shapes such as green bodies made from such compositions.

  本发明涉及某些至少部分中和的羧基丙烯酸聚合物，它们是水性载体中无机粉末和 金属粉末的活性分散剂。这些羧化丙烯酸聚合物至少部分与季有机氢氧化铵中和。 在一个实施方案中，这种中和羧基化丙烯酸聚合物包括一种水溶性聚合物，它具有丙烯酸骨架和沿骨架间隔分布的羧基。这种聚合物至少部分与水溶性季有机氢氧化铵中和，至少中和了部分羧基。中和聚合物可用于在水介质中分散粉末，这种粉末可在水介质中释放出一种或多种多价金属阳离子。中和聚合物在水介质中的浓度为所述粉末释放到水介质中的多价阳离子的浓度，以及分散剂聚合物的浓度足以实现无机粉末的分散时，该聚合物在溶液中稳定，不会作为金属聚合物复合物沉淀。 本发明进一步在于将此类聚合物材料用作分散剂，用于含有此类材料的水性配方和组合物，以及用于由此类组合物制成的绿色体等形状。
• Total synthesis method for making an indole structure derivative product class, of the triptamine type, in particular, melatonin or N-acetyl-5-methoxytriptamine type, having a high purity degree and easily soluble, for therapeutic use against acquired immuno-deficiency syndromes
  申请人：I.F.L.O. S.a.s. di Giorgio e Aldo Laguzzi

  公开号：EP0330625A2

  公开（公告）日：1989-08-30

  The present invention relates to : 1) a method for the total synthesis of an indole struc­ture derivative product class,of the triptamine type, in particular of the melatonine or N-Acetyl-5-Methoxy-­triptamine type; 2) the use of melatonine or N-acetyl-5-methoxytriptamine as a drug with doses from 2 mg to 20 mg per day,in an oral,intramuscolar or endovenous way; 3) the use of melatonine or N-acetyl-5-methoxytriptamine, in combination with an azidothymidine treating process, in order to improve the curative effects. The subject total synthesis process consists of combining potassium phthalamide and di-bromopropane in order to obtain 3-bromopropylphthalamide;adding, in the presence of ethanol dissolved sodium,acetacetic esther in order to obtain ethyl-2-acetyl-5-phthalimido-penta­ noate ;adding diazo-p-anisidine so as to obtain 2-­carboxyethyl-3-(2-phthalimidoethyl)-5-methoxy-indole. The main feature of the invention is that to the 2-carboxyethyl-3-(2-phthalimidoethyl)-5-methoxy­-indole there are added NaOH 2N and 20% H₂SO₄ in order to obtain raw 5-methoxytriptamine;which is purified by means of hexamethyldisilazane,with the formation of the related mono and bi-derivative therefrom there is obtain­ed the starting product which is purified by means of aqueous methanol. The subject method,in particular,is specifically designed for provided high purity melatonine,or N-acetyl-­5-methoxytriptamine,with a great yield,which is water soluble and may be used for therapeutic purposes. The thus obtained melatonine,has such a purity that it can be used,in suitable packages,both in tumoral phrophilaxy and tumoral terapy,as well as against the acquired immuno-deficiency syndromes,o so called AIDS.

  本发明涉及： 1) 三色胺类吲哚结构衍生物产品，特别是褪黑素或N-乙酰基-5-甲氧基-triptamine类吲哚结构衍生物产品的全合成方法； 2) 使用褪黑素或 N-乙酰基-5-甲氧基-triptamine 作为药物，每天剂量从 2 毫克到 20 毫克不等，口服、肌注或静脉注射； 3) 将褪黑素或 N-乙酰-5-甲氧基雷公藤多甙与叠氮胸苷治疗过程结合使用，以提高疗效。 本发明的总合成工艺包括：将邻苯二甲酰胺钾和二溴丙烷混合，得到 3-溴丙基邻苯二甲酰胺；在乙醇溶解钠的存在下，加入乙酸乙酯，得到 2-乙酰基-5-酞酰亚胺基五壬酸乙酯；加入重氮对甲氧基苯胺，得到 2-羧乙基-3-(2-酞酰亚胺基乙基)-5-甲氧基吲哚。 本发明的主要特点是，在 2-羧乙基-3-(2-酞酰亚胺基乙基)-5-甲氧基-吲哚中加入 2N NaOH 和 20% H₂SO₄ 以得到 5-甲氧基三尖杉胺原料；该原料通过六甲基二硅氮烷纯化，形成相关的单衍生物和双衍生物，从而得到起始产物，该起始产物通过甲醇水溶液纯化。 该方法特别设计用于提供高纯度的褪黑素或 N-乙酰基-5-甲氧基三尖杉酯胺，产量高，可溶于水，可用于治疗目的。 由此获得的褪黑素纯度极高，可以在适当的包装中用于肿瘤治疗和肿瘤治疗，也可用于防治获得性免疫缺陷综合症（即所谓的艾滋病）。
• Partially methylated polyamines as epoxy curing agents
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0737702A2

  公开（公告）日：1996-10-16

  A curable epoxy resin composition comprising a polyepoxide resin and an amine curative characterized in that the amine curative comprises a partially methylated polyalkylene polyamine having at least three amine nitrogens and at least two active amine hydrogens.

  一种由聚环氧树脂和胺固化剂组成的可固化环氧树脂组合物，其特征在于胺固化剂由部分甲基化的聚亚烷基多胺组成，该多胺具有至少三个胺硝基和至少两个活性胺氢基。
• PROCESS FOR THE PREPARATION OF 1-[CYANO (4-HYDROXYPHENYL)METHYL]CYCLOHEXANOL COMPOUNDS
  申请人：Wyeth

  公开号：EP1902015A1

  公开（公告）日：2008-03-26