of 9- and 7-alkylpurines, being the 9-alkylpurines the major regioisomers. The presence of the terpenyl residue induced cytotoxicity on simple purines and, in general, that activity improved as the substituent was larger. The 7-diterpenyl-6-chloropurine E-21b was the most cytotoxic in the series and it can be considered an analogue of the marine natural compounds agelasines and agelasimines, which were
几种新的萜烯
嘌呤衍
生物是通过不同的
嘌呤与衍生自天然
萜类化合物的卤化试剂烷基化而制得的,所述天然萜烯化合物可商购获得或从圆锥形梭菌的视锥中分离出来,然后进一步转化为合适的烷基化试剂。
嘌呤的烷基化得到9-和7-烷基
嘌呤的混合物,这是9-烷基
嘌呤的主要区域异构体。萜烯残基的存在对简单的
嘌呤诱导细胞毒性,并且通常,随着取代基的增加,该活性提高。7-二萜烯基-
6-氯嘌呤E - 21b是该系列中最具细胞毒性的,可以被认为是海洋天然化合物agelasines和agelasimines的类似物,这些化合物被用作这项工作的模型。