6,7-二氯-3-氧代-3,4-二氢喹噁啉-2-羧酸 | 75294-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 6,7-二氯-3-氧代-3,4-二氢喹噁啉-2-羧酸
• 英文名称: 6,7-dichloro-3-hydroxy-2-quinoxalinecarboxylic acid
• 英文别名: DCHQC；6,7-dichloro-3-hydroxyquinoxaline-2-carboxylic acid
• CAS: 75294-00-7
• 化学式: C₉H₄Cl₂N₂O₃
• 分子量: 259.048
• InChiKey: LWFDMVFVKWWYFN-UHFFFAOYSA-N

物化性质

• 密度：
  1.84±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6,7-二氯-3-氧代-3,4-二氢喹噁啉-2-羧酸 在 硝基苯 作用下， 生成 2-羟基-6,7-二氯喹喔啉
  参考文献：
  名称：

  924.几种具有生物学意义的喹喔啉

  摘要：

  DOI：

  10.1039/jr9560004731
• 作为产物：
  描述：

  1,2-二氯-4,5-二硝基苯 在 sodium hydroxide 、 乙醇 、 镍 作用下， 生成 6,7-二氯-3-氧代-3,4-二氢喹噁啉-2-羧酸
  参考文献：
  名称：

  924.几种具有生物学意义的喹喔啉

  摘要：

  DOI：

  10.1039/jr9560004731

文献信息

• Antiviral combinations
  申请人：Eli Lilly and Company

  公开号：US04210647A1

  公开（公告）日：1980-07-01

  Antiviral combinations containing a 2-ester-substituted-3,4-dihydro-3-oxoquinoxaline and a hindered amine.

  抗病毒组合物包含2-酯基取代的3,4-二氢-3-氧喹诺啉和受阻胺。
• Substituted 1H-quinoxalin-2-one compounds and substituted 4-aryl- and 4-heteroarylcyclohexane compounds
  申请人：——

  公开号：US20040224954A1

  公开（公告）日：2004-11-11

  The invention relates to substituted (1H)quinoxalin-2-one compounds, methods for production thereof, medicaments containing said compounds and the use of said compounds for the production of medicaments. The invention further relates to substituted 4-aryl- and 4-heteroarylcyclohexane compounds and methods for production thereof.

  本发明涉及取代的(1H)喹喔啉-2-酮化合物，其制备方法，含有该化合物的药物以及使用该化合物制备药物的用途。本发明还涉及取代的4-芳基和4-杂环芳基环己烷化合物及其制备方法。
• Pharmaceutical composition containing 3,4-dihydro-3-oxo-2-quinoxalines, novel such quinoxalines and processes for the production thereof
  申请人：ELI LILLY AND COMPANY

  公开号：EP0010426A1

  公开（公告）日：1980-04-30

  A pharmaceutical composition characterized by as active ingredient a 3,4-dihydro-3-oxoquinoxaline of the formula: wherein R and R4 are individually H, NO2 or CH30; R1 and R2 are individually H, NO2, CH3O or halo such that at least one of R, R1, R2 and R4 is otherthan H, such that if neitherR1 and R2 is NO2 orCH3O, both RR1 and R2 are individually halo and both R and R4 are H, and such that one ofR1 and R2 is CH3O only if one of R, R1, R2 and R4 is NO2; R3 is C1-C4 alkyl, C3-C6 cycloalkyl, C3-C4 alkenyl, H or 2-chloroethyl; and n is 0 or 2, e.g. ethyl 6,7-dibromo- 3,4-dihydro-3-oxo-2- quinoxaline carboxylate, and excipients is useful for suppressing viral infection in mammals. All but one of the quinoxalines disclosed are new. The compounds are prepared by reacting an o-phenyiene diamine with an a-ketodibasic acid. Certain of the compounds are prepared by reacting a 6-nitro-4,5- disubstituted aniline with an alkyl malonyl chloride followed by annelation in the presence of sodium ethoxide and then treatment with phosphorus trichloride.

  一种药物组合物，其活性成分为式 3，4-二氢-3-氧代喹喔啉： 其中R和R4分别为H、NO2或CH30；R1和R2分别为H、 、CH3O或卤素，这样R、R1、R2和R4中至少有一个不是H，这样如果R1和R2都不是 或 ，RR1和R2都分别为卤素，R和R4都是H，这样只有当R、R1、R2和R4中的一个是 时，R1和R2中的一个才是 ；R3 是 C1-C4 烷基、C3-C6 环烷基、C3-C4 烯基、H 或 2-氯乙基；且 n 是 0 或 2，例如例如，6,7-二溴-3,4-二氢-3-氧代-2-喹喔啉羧酸乙酯和辅料可用于抑制哺乳动物的病毒感染。除一种喹喔啉外，所披露的所有喹喔啉都是新化合物。这些化合物是通过邻苯基二胺与 a-酮二元酸反应制备的。某些化合物是通过 6-硝基-4,5-二取代苯胺与烷基丙二酰氯反应，然后在乙醇钠存在下环化，再用三氯化磷处理而制备的。
• Salts of dihalo-2-quinoxaline carboxylic acids, their preparation and pharmaceutical formulations containing them
  申请人：ELI LILLY AND COMPANY

  公开号：EP0029658A1

  公开（公告）日：1981-06-03

  There is described novel hindered amine salts of 6,7 dihalo-3,4-dihydro-3 -oxo-2-quinoxaline carboxylic acids of the formula I: wherein R and R1 are independently halogen; R2 is H, CH3, or C2H5; R3, when taken singly, is H, CH3, C2H5, C2H4OH, CH2C6H5 or CH2COOC2H5; R4, when taken singly, is a hindered hydrocarbyl radical of the group consisting of cycloactyl, norbornyl, Ad and CHR2Ad wherein Ad is a 1-adamantyl, a 2-adamantyl, a 3-(4-homoiso) twistane or a tricycloundecane radical; and R3 and R4 when taken together with the nitrogen to which they are attached, form an adamantylspiropyrrolidine radical. The compounds are prepared by treatment of the free acid with the free base or a salt of the appropriate hindered amine. They are effective antiviral agents in mammels.

  描述了式 I 的 6,7-二卤-3,4-二氢-3-氧代-2-喹喔啉羧酸的新型受阻胺盐： 其中 R 和 R1 独立地为卤素；R2 为 H、CH3 或 C2H5；R3 单个时为 H、 、 、C2H4OH、CH2C6H5 或 CH2COO ；单个 R4 是环内酯、降冰片烷基、Ad 和 CHR2Ad 所组成的组中的受阻烃基，其中 Ad 是 1-金刚烷基、2-金刚烷基、3-（4-异构）扭烷基或三环十一烷基；R3 和 R4 与它们所连接的氮一起形成金刚烷基-螺咯烷基。这些化合物是用游离碱或适当的受阻胺盐处理游离酸而制备的。它们是哺乳动物的有效抗病毒剂。
• Biosensors and methods of using the same
  申请人：——

  公开号：US20020182642A1

  公开（公告）日：2002-12-05

  The present invention relates to a method for detection of receptor antagonists comprising the following steps: (I) a sample containing the receptor antagonist is fractionated by use of a liquid-based separation means, preferably capillary electrophoresis, (II) a fraction containing the receptor antagonist or modulator is fed directly to a biosensor (9) which is activated by an appropriate receptor agonist and, as a result of this activation, is generating a measurable response, said agonist being fed to the biosensor through the liquid-based separation means together with the antagonist or modulator, said activation of the biosensor ( 9 ) being pulsed by delivery of the receptor agonist to the biosensor for short period of times, said periods being separated by other periods when no agonist is delivered to the biosensor, and (III) the change of the response resulting from deactivation of the receptor agonist-activated biosensor by the receptor antagonist or modulator is measured, preferably by means of a patch clamp electrode ( 8 ). It is further possible to resensitize the biosensor desensitized as above by use of pulsed superfusion of the biosensor. The present invention also relates to an apparatus usable for practicing the above mentioned method.

  本发明涉及一种检测受体拮抗剂的方法，包括以下步骤：(I)使用液基分离手段，最好是毛细管电泳，将含有受体拮抗剂的样品分馏；(II)将含有受体拮抗剂或调节剂的样品直接送入生物传感器(9)，该生物传感器被适当的受体激动剂激活，并由于这种激活而产生可测量的反应，所述激动剂与拮抗剂或调节剂一起通过液基分离手段送入生物传感器，所述激活生物传感器( 9 (III) 受体拮抗剂或调节剂使受体激动剂激活的生物传感器失活后产生的反应的变化，最好通过膜片钳电极( 8 ). 此外，还可以通过对生物传感器进行脉冲超灌，使如上所述脱敏的生物传感器重新敏化。 本发明还涉及一种可用于实施上述方法的装置。