N-benzhydryloctan-1-amine | 128297-93-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzhydryloctan-1-amine
• 英文别名: N-(α-phenyl-benzyl)-octylamine
• CAS: 128297-93-8
• 化学式: C₂₁H₂₉N
• 分子量: 295.468
• InChiKey: UYMGBZVFDDPHAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(1-benzotriazolyl-benzyl)-N-octyl-amino-aceton itrile 在 copper(II) sulfate 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 13.5h， 生成 N-benzhydryloctan-1-amine
  参考文献：
  名称：

  Katritzky, Alan R.; Latif, Muhammad; Urogdi, Laszlo, Journal of the Chemical Society. Perkin transactions I, 1990, p. 667 - 672

  摘要：

  DOI：

文献信息

• Taking the F out of FLP: Simple Lewis Acid–Base Pairs for Mild Reductions with Neutral Boranes via Borenium Ion Catalysis
  作者：Patrick Eisenberger、Adrian M. Bailey、Cathleen M. Crudden

  DOI：10.1021/ja307374j

  日期：2012.10.24

  Discrete three-coordinate borenium salts 1c and 1d are accessed by cooperative Lewis acid-base pair-mediated heterolytic splitting of the B-H bond in pinacolborane by B(C6F5)(3)center dot DABCO and Ph3C+/DABCO, respectively. The resulting salts are competent catalysts in the reduction of a broad range of imines and can be generated in situ. Moreover, a mechanistic framework for borenium catalysis based on experimental evidence is proposed. The reaction is suggested to proceed by borenium activation of the imine substrate followed by counterintuitive hydride delivery from HBPin (with the assistance of DABCO) rather than from the HB(C6F5)(3)(-) anion, contrary to typical mechanisms of reduction in FLP systems.
• KATRITZKY, ALAN R.;LATIF, MUHAMMAD;UROGDI, LASZLO, J. CHEM. SOC. PERKIN TRANS. PT 1,(1990) N, C. 667-672
  作者：KATRITZKY, ALAN R.、LATIF, MUHAMMAD、UROGDI, LASZLO

  DOI：——

  日期：——
• Katritzky, Alan R.; Latif, Muhammad; Urogdi, Laszlo, Journal of the Chemical Society. Perkin transactions I, 1990, p. 667 - 672
  作者：Katritzky, Alan R.、Latif, Muhammad、Urogdi, Laszlo

  DOI：——

  日期：——