1,1-bis[3-bromo-3'-chloro-4',6-dihydroxy-5,5'-dimethoxycarbonyl diphenyl]methane | 244262-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-bis[3-bromo-3'-chloro-4',6-dihydroxy-5,5'-dimethoxycarbonyl diphenyl]methane
• 英文别名: Methyl 5-[(5-bromo-2-hydroxy-3-methoxycarbonyl-phenyl)methyl]-3-chloro-2-hydroxy-benzoate；methyl 5-[(5-bromo-2-hydroxy-3-methoxycarbonylphenyl)methyl]-3-chloro-2-hydroxybenzoate
• CAS: 244262-49-5
• 化学式: C₁₇H₁₄BrClO₆
• 分子量: 429.652
• InChiKey: UBOZAZQJNZTLRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1-bis[3-bromo-3'-chloro-4',6-dihydroxy-5,5'-dimethoxycarbonyl diphenyl]methane 在 sodium hydroxide 、 锌 作用下， 以77%的产率得到1,1-bis[3-chloro-3',5-carbonxy=2,4'-dihydroxydiphenyl]methane
  参考文献：
  名称：

  Synthesis and Anti-HIV Activity of Cosalane Analogues with Substituted Benzoic Acid Rings Attached to the Pharmacophore through Methylene and Amide Linkers

  摘要：

  The cosalane pharmacophore has been extended by the attachment of two additional substituted benzoic acid rings through amide and methylene linkers. The resulting compounds display significant antiviral activity when tested in vitro for inhibition of the cytopathic effects of HIV-1(RF) in CEM-SS cells and HIV-1(IIIB) in MT-4 cells. The compound containing the methylene linker also shows moderate activity versus HIV-2(ROD) in MT-4 cells. Because cosalane and related compounds containing extended pharmacophores inhibit the binding of gp120 to CD4, the presently described new compounds are assumed to act by a similar mechanism. A hypothetical model is proposed for the binding of the methylene-linked compound to CD4.

  DOI：

  10.1021/jo990177f
• 作为产物：
  描述：

  5-溴水杨酸 在 sodium hydroxide 、 sodium tetrahydroborate 、 硫酸 、 三氟乙酸 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 32.0h， 生成 1,1-bis[3-bromo-3'-chloro-4',6-dihydroxy-5,5'-dimethoxycarbonyl diphenyl]methane
  参考文献：
  名称：

  Synthesis and Anti-HIV Activity of Cosalane Analogues with Substituted Benzoic Acid Rings Attached to the Pharmacophore through Methylene and Amide Linkers

  摘要：

  The cosalane pharmacophore has been extended by the attachment of two additional substituted benzoic acid rings through amide and methylene linkers. The resulting compounds display significant antiviral activity when tested in vitro for inhibition of the cytopathic effects of HIV-1(RF) in CEM-SS cells and HIV-1(IIIB) in MT-4 cells. The compound containing the methylene linker also shows moderate activity versus HIV-2(ROD) in MT-4 cells. Because cosalane and related compounds containing extended pharmacophores inhibit the binding of gp120 to CD4, the presently described new compounds are assumed to act by a similar mechanism. A hypothetical model is proposed for the binding of the methylene-linked compound to CD4.

  DOI：

  10.1021/jo990177f

文献信息

• Synthesis and Anti-HIV Activity of Cosalane Analogues with Substituted Benzoic Acid Rings Attached to the Pharmacophore through Methylene and Amide Linkers
  作者：Jeffrey A. Ruell、Erik De Clercq、Christophe Pannecouque、Myriam Witvrouw、Tracy L. Stup、Jim A. Turpin、Robert W. Buckheit,、Mark Cushman

  DOI：10.1021/jo990177f

  日期：1999.8.1

  The cosalane pharmacophore has been extended by the attachment of two additional substituted benzoic acid rings through amide and methylene linkers. The resulting compounds display significant antiviral activity when tested in vitro for inhibition of the cytopathic effects of HIV-1(RF) in CEM-SS cells and HIV-1(IIIB) in MT-4 cells. The compound containing the methylene linker also shows moderate activity versus HIV-2(ROD) in MT-4 cells. Because cosalane and related compounds containing extended pharmacophores inhibit the binding of gp120 to CD4, the presently described new compounds are assumed to act by a similar mechanism. A hypothetical model is proposed for the binding of the methylene-linked compound to CD4.