Diethyl 2,2-bis[2-(9-benzylpurin-6-yl)ethyl]propanedioate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: Diethyl 2,2-bis[2-(9-benzylpurin-6-yl)ethyl]propanedioate
• 化学式: C₃₅H₃₆N₈O₄
• 分子量: 632.722
• InChiKey: WWVMVPXVKOWTOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  47
• 可旋转键数：
  16
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  140
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  9-benzyl-6-vinyl-9H-purine 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 29.0h， 生成 Diethyl 2,2-bis[2-(9-benzylpurin-6-yl)ethyl]propanedioate
  参考文献：
  名称：

  Addition of Nucleophiles to 6-Vinylpurines.

  摘要：

  6-Vinylpurines readily participate in nucleophilic addition reactions. Treatment with sodium salts of alcohols and thiols, as well as stabilised carbanions, results in clean conversion into a variety of functionalized purine derivatives. Additions performed in the presence of acid give 1 : 1 adducts together with dimeric purine products. Under acidic conditions the adduct first formed reacts further with another molecule of vinylpurine.

  DOI：

  10.3891/acta.chem.scand.51-1116

文献信息

• Addition of Nucleophiles to 6-Vinylpurines.
  作者：Anniken T. Øverås、Anne Kristin Bakkestuen、Lise-Lotte Gundersen、Frode Rise、Michael P. Hartshorn、Manuela Merchán、Ward T. Robinson、Björn O. Roos、Claire Vallance、Bryan R. Wood

  DOI：10.3891/acta.chem.scand.51-1116

  日期：——

  6-Vinylpurines readily participate in nucleophilic addition reactions. Treatment with sodium salts of alcohols and thiols, as well as stabilised carbanions, results in clean conversion into a variety of functionalized purine derivatives. Additions performed in the presence of acid give 1 : 1 adducts together with dimeric purine products. Under acidic conditions the adduct first formed reacts further with another molecule of vinylpurine.