N1-(4-氯苯基)苯-1,4-二胺 | 13065-93-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N1-(4-氯苯基)苯-1,4-二胺
• 英文名称: 4-amino-4'-chlorodiphenylamine
• 英文别名: N-(4-chlorophenyl)-p-phenylenediamine；N-(4-chloro-phenyl)-p-phenylenediamine；N-(4-Chlor-phenyl)-p-phenylendiamin；4'-Chlor-4-amino-diphenylamin；4-Amino-4'-chlor-diphenylamin；N1-(4-Chlorophenyl)benzene-1,4-diamine；4-N-(4-chlorophenyl)benzene-1,4-diamine
• CAS: 13065-93-5
• 化学式: C₁₂H₁₁ClN₂
• mdl: MFCD07429574
• 分子量: 218.686
• InChiKey: NLGIEISQJFZTIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2921590090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  N1-(4-氯苯基)苯-1,4-二胺 以68%的产率得到
  参考文献：
  名称：

  HAMADA YOSHIKI; MATSUOKA HIDEKO, YAKUGAKU DZASSI, YAKUGAKU ZASSNI, J. PHARM. SOS. JAR. , 1976, 96+

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯亚硝基苯 在 硫酸 、 ammonium chloride 、 溶剂黄146 、 锌 作用下， 生成 N1-(4-氯苯基)苯-1,4-二胺
  参考文献：
  名称：

  Bamberger; Ham, Justus Liebigs Annalen der Chemie, 1911, vol. 382, p. 114

  摘要：

  DOI：

文献信息

• ARYL- AND HETEROARYL-SUBSTITUTED BENZENE DERIVATIVES AS MODULATORS OF PI3-KINASE SIGNALLING PATHWAYS
  申请人：Neuropore Therapies, Inc.

  公开号：US20150197513A1

  公开（公告）日：2015-07-16

  The present disclosure relates to certain aryl- or heteroaryl-substituted benzene derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.

  本公开涉及某些含芳基或杂芳基取代的苯衍生物、含有它们的制药组合物以及使用它们的方法，包括调节自噬或预防、逆转、减缓或抑制PI3K-AKT-MTOR途径的方法，以及治疗与自噬或PI3K-AKT-MTOR途径相关的疾病的方法。
• Synthesis, characterization and application of magnetic mesoporous Fe3O4@Fe-Cu/MCM‐41 as efficient and recyclable nanocatalyst for the Buchwald-Hartwig C-N cross-coupling reaction
  作者：Mohammad Abdollahi-Alibeik、Zahra Ramazani

  DOI：10.1007/s12039-022-02066-w

  日期：2022.9

  prepared and applied as a nanostructured catalyst in the Buchwald-Hartwig C-N cross-coupling reaction. The textural properties of the core-shell catalyst have been studied by means of XRD, FTIR, SEM, EDX, BET, and VSM techniques. The catalyst samples with various Si:Cu:Fe molar ratios were used in the C-N coupling, and the reaction data shows that Fe3O4@Fe-Cu/MCM-41 with Si:Cu:Fe molar ratio of 60:1.5:1

  制备了MCM-41 负载的带有磁芯的 Cu 和 Fe (Fe 3 O 4 @Fe-Cu/MCM-41)，并将其用作 Buchwald-Hartwig CN 交叉偶联反应中的纳米结构催化剂。核壳催化剂的结构性质已经通过XRD、FTIR、SEM、EDX、BET和VSM技术进行了研究。不同Si:Cu:Fe摩尔比的催化剂样品用于CN偶联，反应数据表明Si:Cu:Fe摩尔比为60:1.5的Fe 3 O 4 @Fe-Cu/MCM-41: 1具有较好的催化性能。制备的催化剂可以多次回收和重复使用，而活性和磁性没有任何显着降低。 图形概要 制备了MCM-41 负载的带有磁芯的 Cu 和 Fe (Fe 3 O 4 @Fe-Cu/MCM-41)，并将其用作 Buchwald-Hartwig CN 交叉偶联反应中的纳米结构催化剂。Si:Cu:Fe摩尔比为60:1.5:1的催化剂具有更好的催化性能，可以多次回收重复使用，活性没有明显下降。
• Anti-bacterial polymer and method for the preparation thereof, anti-bacterial polymer film and method for the preparation thereof, and article having such a film on the surface thereof
  申请人：ULVAC, INC.

  公开号：EP1396514A1

  公开（公告）日：2004-03-10

  An anti-bacterial polymer of the present invention consists of a vapor deposition-polymerization reaction product of a diaminobenzoic acid monomer or halogen atom-containing diamine monomer and a monomer reactive with these monomers. The anti-bacterial polymer can be prepared by a method, which comprises the step of subjecting a gas obtained by evaporating a diaminobenzoic acid monomer or halogen atom-containing diamine monomer and a gas obtained by evaporating a monomer reactive with these monomers to vapor deposition-polymerization, in a vacuum, to thus form an anti-bacterial polymer. The method permits the formation of a film having a desired thickness even on the surface having a complicated shape such as the surface of, for instance, a heat exchanger.

  本发明的抗菌聚合物由二氨基苯甲酸单体或含卤原子的二胺单体和与这些单体反应的单体的气相沉积-聚合反应产物组成。抗菌聚合物的制备方法包括以下步骤：将蒸发二氨基苯甲酸单体或含卤素原子的二胺单体得到的气体和蒸发与这些单体反应的单体得到的气体在真空中进行气相沉积-聚合反应，从而形成抗菌聚合物。这种方法即使在形状复杂的表面（如热交换器表面）上也能形成具有所需厚度的薄膜。
• Balboni, Claudio; Benati, Luisa; Montevecchi, P. Carlo, Journal of the Chemical Society. Perkin transactions I, 1983, p. 2111 - 2117
  作者：Balboni, Claudio、Benati, Luisa、Montevecchi, P. Carlo、Spagnolo, Piero

  DOI：——

  日期：——
• Selective inducible microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from an oxicam template
  作者：Jane Wang、David Limburg、Jeff Carter、Gabriel Mbalaviele、James Gierse、Michael Vazquez

  DOI：10.1016/j.bmcl.2010.01.060

  日期：2010.3

  Here we describe the SAR of a series of potent and selective mPGES-1 inhibitors based on an oxicam template. Compound 13j demonstrated low nanomolar mPGES-1 inhibition in an enzyme assay. In addition, it displayed PGE(2) inhibition in a cell-based assay (0.42 mu M) and had over 238-fold selectivity for mPGES-1 over COX-2 and over 200-fold selectivity for mPGES-1 over 6-keto PGF(1 alpha). (C) 2010 Elsevier Ltd. All rights reserved.