(E)-N-[3-benzoyl-4-[[2-(4-methylphenyl)acetyl]amino]phenyl]-3-(4-phenylphenyl)prop-2-enamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-[3-benzoyl-4-[[2-(4-methylphenyl)acetyl]amino]phenyl]-3-(4-phenylphenyl)prop-2-enamide
• 化学式: C₃₇H₃₀N₂O₃
• 分子量: 550.657
• InChiKey: NTHBDSFXWYYUDJ-PTGBLXJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  42
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2E)-3-(1,1'-biphenyl-4-yl)acrylic acid 在 氯化亚砜 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 (E)-N-[3-benzoyl-4-[[2-(4-methylphenyl)acetyl]amino]phenyl]-3-(4-phenylphenyl)prop-2-enamide
  参考文献：
  名称：

  Discovery of a novel lead structure for anti-malarials

  摘要：

  From a library of 61 compounds available from former studies 2,5-bis-acylaminobenzophenone 7p was identified as a lead structure for a novel class of anti-malaria agents active against multi-resistant Plasmodium falciparum strain Dd2. Some structural modifications of this initial lead demonstrated the potential for further improvement of the anti-plasmodial activity of this novel class of anti-malarials. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00296-0

文献信息

• Discovery of a novel lead structure for anti-malarials
  作者：Jochen Wiesner、Pia Wißner、Hans-Martin Dahse、Hassan Jomaa、Martin Schlitzer

  DOI：10.1016/s0968-0896(00)00296-0

  日期：2001.3

  From a library of 61 compounds available from former studies 2,5-bis-acylaminobenzophenone 7p was identified as a lead structure for a novel class of anti-malaria agents active against multi-resistant Plasmodium falciparum strain Dd2. Some structural modifications of this initial lead demonstrated the potential for further improvement of the anti-plasmodial activity of this novel class of anti-malarials. (C) 2001 Elsevier Science Ltd. All rights reserved.