6-O-苯甲酰基-D-葡萄糖 | 14200-76-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 6-O-苯甲酰基-D-葡萄糖
• 英文名称: O⁶-Benzoyl-D-glucose
• 英文别名: D-glucose, 6-benzoate；[(2R,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl] benzoate
• CAS: 14200-76-1
• 化学式: C₁₃H₁₆O₇
• 分子量: 284.266
• InChiKey: VKUVHQLMDOUYND-IRCOFANPSA-N

物化性质

• 沸点：
  558.7±50.0 °C(Predicted)
• 密度：
  1.430±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6-O-苯甲酰基-D-葡萄糖 、 乙酸酐 在 sodium acetate 作用下， 生成 1,2,3,4-tetra-O-acetyl-6-O-benzoyl-β-D-glucopyranose
  参考文献：
  名称：

  Brigl; Zerrweck, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1934, vol. 229, p. 117,121

  摘要：

  DOI：
• 作为产物：
  描述：

  D-葡萄糖-二乙基缩硫醛 在 乙醇 、 barium carbonate 、 mercury dichloride 作用下， 生成 6-O-苯甲酰基-D-葡萄糖
  参考文献：
  名称：

  Brigl; Gruener, Justus Liebigs Annalen der Chemie, 1932, vol. 495, p. 60,71

  摘要：

  DOI：

文献信息

• Process for production of chlorinated sucrose based on hydrophobic affinity chromatography
  申请人：Ratnam Rakesh

  公开号：US20100222570A1

  公开（公告）日：2010-09-02

  This invention relates to a process for selective capture, isolation and purification of chlorinated sucrose compounds, including chlorinated sucrose, their precursors and derivatives, including trichlorogalactosucrose (TGS), directly from chlorinated reaction mixture by column chromatography on adsorbents and under conditions which result in specific and selective affinity towards one or more of chlorinated sucrose compound. The process also integrates de-esterification of chlorinated sucrose esters adsorbed on the adsorbent while they are being treated with desorbent. The process also provides a novel approach to concentration and crystallization of TGS. The chlorinated sucrose derivatives, including TGS, thus isolated are substantially free from most impurities, salts and organic solvents. The process has high recovery of more than 95% in terms of desired chlorinated sucrose derivatives including TGS.

  本发明涉及一种从氯化反应混合物中通过吸附剂柱层析和在特定条件下对氯化蔗糖化合物，包括氯化蔗糖、其前体和衍生物，如三氯半乳糖蔗糖（TGS）进行选择性捕获、分离和纯化的过程。该过程还结合了在吸附剂上吸附的氯化蔗糖酯在处理解吸剂时的去酯化。该过程还提供了一种新的浓缩和结晶TGS的方法。因此，分离出的包括TGS在内的氯化蔗糖衍生物基本上不含大多数杂质、盐和有机溶剂。该过程具有高达95%以上的期望氯化蔗糖衍生物，包括TGS的高回收率。
• DDS compound and method for measurement thereof
  申请人：Daiichi Pharmaceutical Co., Ltd.

  公开号：US20040192644A1

  公开（公告）日：2004-09-30

  A DDS compound comprising a carboxy(C 1-4 )alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C 1-4 )alkyldextran polyalcohol, and a method for measuring a DDS compound in which a polymer carrier and a residue of drug compound are bound to each other by means of a spacer comprising 2 to 8 amino acids linked by peptide bond(s), which comprises the steps of treating the DDS compound with a peptidase, and measuring the resulting hydrolysate.

  一种DDS化合物，包括一种羧基（C1-4）烷基葡聚糖多醇，该多醇被一种糖化合物修饰，并且一种药物化合物残基与羧基（C1-4）烷基葡聚糖多醇结合，以及一种测量DDS化合物的方法，其中聚合物载体和药物化合物残基通过含有2至8个氨基酸的间隔物相互结合，该间隔物由肽键连接，包括以下步骤：用肽酶处理DDS化合物，并测量所得的水解物。
• DDS COMPOUNDS AND METHOD FOR ASSAYING THE SAME
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1155702A1

  公开（公告）日：2001-11-21

  A DDS compound comprising a carboxy(C1-4)alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C1-4)alkyldextran polyalcohol, and a method for measuring a DDS compound in which a polymer carrier and a residue of drug compound are bound to each other by means of a spacer comprising 2 to 8 amino acids linked by peptide bond(s), which comprises the steps of treating the DDS compound with a peptidase, and measuring the resulting hydrolysate.

  一种 DDS 化合物，包括用糖类化合物修饰的羧基（C1-4）烷基葡聚糖聚醇和与羧基（C1-4）烷基葡聚糖聚醇结合的药物化合物残留物；以及一种测定 DDS 化合物的方法，其中聚合物载体和药物化合物残留物通过由肽键连接的 2 至 8 个氨基酸组成的间隔物相互结合，该方法包括用肽酶处理 DDS 化合物和测定所得水解物的步骤。
• DDS compounds and method for assaying the same
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1619210A1

  公开（公告）日：2006-01-25

  A DDS compound comprising a carboxy(C1-4)alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C1-4)alkyldextran polyalcohol, and a method for measuring a DDS compound in which a polymer carrier and a residue of drug compound are bound to each other by means of a spacer comprising 2 to 8 amino acids linked by peptide bond(s), which comprises the steps of treating the DDS compound with a peptidase, and measuring the resulting hydrolysate.

  一种 DDS 化合物，包括用糖类化合物修饰的羧基（C1-4）烷基葡聚糖聚醇和与羧基（C1-4）烷基葡聚糖聚醇结合的药物化合物残留物；以及一种测定 DDS 化合物的方法，其中聚合物载体和药物化合物残留物通过由肽键连接的 2 至 8 个氨基酸组成的间隔物相互结合，该方法包括用肽酶处理 DDS 化合物和测定所得水解物的步骤。
• Pressure-sensitive adhesive comprising a polymer component and a saccharide component and method for bonding a first substrate to a second substrate with same
  申请人：TESA SE

  公开号：US10711164B2

  公开（公告）日：2020-07-14

  Pressure-sensitive adhesive compound comprising a polymer component and a saccharide component, wherein the saccharide component is formed from one or more monosaccharides, disaccharides, oligosaccharides, or polysaccharides, and/or one or more modified saccharide derivatives, which can be derived from monosaccharides, disaccharides, oligosaccharides or polysaccharides by modifying one, several, or all OH groups contained in the respective saccharide.

  压敏型胶粘剂化合物，包括聚合物成分和糖类成分，其中糖类成分由一种或多种单糖、二糖、低聚糖或多糖和/或一种或多种改性糖类衍生物组成，这些糖类衍生物可通过改性单糖、二糖、低聚糖或多糖中含有的一个、多个或所有 OH 基团而衍生。