1-(10H-吩噻嗪-2-基)-乙醇 | 107772-52-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 1-(10H-吩噻嗪-2-基)-乙醇
• 英文名称: 1-(10H-phenothiazin-2-yl)-ethanol
• 英文别名: 1-(10H-phenothiazin-2-yl)ethanol
• CAS: 107772-52-1
• 化学式: C₁₄H₁₃NOS
• mdl: MFCD01475218
• 分子量: 243.329
• InChiKey: OQJSSFKWEIGNKG-UHFFFAOYSA-N

物化性质

• 沸点：
  440.3±34.0 °C(Predicted)
• 密度：
  1.262±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  57.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(10H-吩噻嗪-2-基)-乙醇 在 aluminum oxide 作用下， 以30%的产率得到2-乙烯基-10H-吩噻嗪
  参考文献：
  名称：

  Synthesis and Properties of 2-Vinylphenothiazine Polymers

  摘要：

  2-Vinylphenothiazine was prepared, and its polymerization was studied. The possibility of using 2-vinylphenothiazine and its polymer as antioxidant in industrial rubber formulations was examined.

  DOI：

  10.1023/b:rjac.0000008312.49788.be
• 作为产物：
  描述：

  吩噻嗪 在 二硫化碳 、 三氯化铝 、 aluminum isopropoxide 、 异丙醇 作用下， 生成 1-(10H-吩噻嗪-2-基)-乙醇
  参考文献：
  名称：

  Schmitt et al., Bulletin de la Societe Chimique de France, 1957, p. 938,943, 944

  摘要：

  DOI：

文献信息

• Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model
  作者：Wei Yang、Xiaolong Liu、Chunli Song、Sen Ji、Jianhong Yang、Yang Liu、Jing You、Jie Zhang、Shenzhen Huang、Wei Cheng、Zhenhua Shao、Linli Li、Shengyong Yang

  DOI：10.1016/j.ejmech.2020.112842

  日期：2021.1

  Ferroptosis is a new type of programmed cell death discovered recently and has been demonstrated to be involved in a number of human diseases such as ischemic stroke. Ferroptosis inhibitors are expected to have potential to treat these diseases. Herein, we report the identification of promethazine derivatives as a new type of ferroptosis inhibitors. Structure-activity relationship (SAR) analyses led

  Ferroptosis是最近发现的一种新型的程序性细胞死亡，并且已证明其参与多种人类疾病，例如缺血性中风。预计铁锈病抑制剂具有治疗这些疾病的潜力。在本文中，我们报告了异丙嗪衍生物作为一种新型的肥大病抑制剂的鉴定。结构活性关系（SAR）分析导致发现最有效的化合物2-（1-（4-（4-（4-甲基哌嗪-1-基）苯基）乙基）-10 H-吩噻嗪（51），该化合物显示出在Estin诱导的HT1080细胞肥大症模型中，EC 50（最大最大有效浓度）值为0.0005μM。在MCAO（大脑中动脉闭塞）缺血性中风模型中，51表现出极好的治疗效果。该化合物还显示出有利的药代动力学性质，特别是渗透血脑屏障的良好能力。总体而言，51可能是治疗与勃起病相关疾病的有前途的先导化合物，值得进一步研究。
• Visible-Light-Promoted Direct Amination of Phenols via Oxidative Cross-Dehydrogenative Coupling Reaction
  作者：Yating Zhao、Binbin Huang、Chao Yang、Wujiong Xia

  DOI：10.1021/acs.orglett.6b01371

  日期：2016.7.15

  between phenols and cyclic anilines via cross-dehydrogenative coupling (CDC) amination that was mediated by visible light, wherein K2S2O8 served as an external oxidant. The salient features of this protocol include circumventing the requirement for prefunctionalized starting materials and achieving single regioselectivity of amination adducts at room temperature.

  公开了一种无过渡金属的方法，该方法通过可见光介导的交叉脱氢偶联（CDC）胺在酚和环状苯胺之间形成分子间芳基C–N键，其中K 2 S 2 O 8用作外部氧化剂。该方案的显着特征包括规避对预功能化原料的需求，并在室温下实现胺加合物的单一区域选择性。
• AZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0721943A1

  公开（公告）日：1996-07-17

  An azole derivative represented by the following general formula (I) a salt thereof, a hydrate thereof or a solvate thereof. This compound has a function to inhibit steroid 17-20 lyase and is useful as preventive and treating agents for prostatic cancer, prostatic hypertrophy, virilism, breast cancer, mastopathy, histeromyoma, and endometriosis.

  由以下通式（I）代表的唑衍生物 其盐、水合物或溶液。 该化合物具有抑制类固醇 17-20 裂解酶的功能，可作为前列腺癌、前列腺肥大症、男性化 症、乳腺癌、乳腺增生症、子宫内膜异位症的预防和治疗药物。
• Spiroborate esters in the borane-mediated asymmetric synthesis of pyridyl and related heterocyclic alcohols
  作者：Viatcheslav Stepanenko、Melvin De Jesús、Wildeliz Correa、Irisbel Guzmán、Cindybeth Vázquez、Lymaris Ortiz、Margarita Ortiz-Marciales

  DOI：10.1016/j.tetasy.2007.10.044

  日期：2007.11

  The effectiveness of several spiroborate ester catalysts was investigated in the asymmetric borane reduction of 2-, 3-, and 4-acetylpyriclines under different reaction conditions. Highly enantiomerically enriched 1-(2-, 3-, and 4-pyridyl)ethanols and 1-(heterocyclic)ethanols were obtained using 1-10% catalytic loads of the spiroborate 5 derived from diphenylprolinol and ethylene glycol. (c) 2007 Elsevier Ltd. All rights reserved.
• Ring Derivatives of Phenothiazine. II. 2-Phenothiazinyl Ketones and Their Derivatives¹
  作者：SAMUEL P. MASSIE、IVAR COOKE、WILLIAM A. HILLS

  DOI：10.1021/jo01115a021

  日期：1956.9