3-O-hexadecyl-2-O-palmitoyl-sn-glycero-1-phosphocholine | 122564-59-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 3-O-hexadecyl-2-O-palmitoyl-sn-glycero-1-phosphocholine
• 英文别名: 1-hexadecyl-2-palmitoyl-sn-glycero-3-phosphocholine；PP plasmanylcholine；[(2S)-2-hexadecanoyloxy-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 122564-59-4
• 化学式: C₄₀H₈₂NO₇P
• 分子量: 720.067
• InChiKey: WOTHHEHCEYHCFE-KDXMTYKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.8
• 重原子数：
  49
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  94.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-O-hexadecyl-2-O-palmitoyl-sn-glycero-1-phosphocholine 、 甲醇 、 sodium hydroxide 以75%的产率得到
  参考文献：
  名称：

  MURARI, M. P.;MURARI, R.;PARTHASARATHY, S.;GUY, C. A.;KUMAR, V. V.;MALEWI+, LIPIDS., 25,(1990) N0, C. 606-612

  摘要：

  DOI：
• 作为产物：
  描述：

  在 palladium dihydroxide 吡啶 、 4-二甲氨基吡啶 、 氢气 作用下， 以 甲醇 、 氯仿 、 水 为溶剂， 反应 64.5h， 生成 3-O-hexadecyl-2-O-palmitoyl-sn-glycero-1-phosphocholine
  参考文献：
  名称：

  An efficient stereocontrolled route to both enantiomers of platelet activating factor and analogs with long-chain esters at C-2: saturated and unsaturated ether glycerolipids by opening of glycidyl arenesulfonates

  摘要：

  DOI：

  10.1021/jo00280a035

文献信息

• The chemical synthesis of a series of ether phospholipids from d-mannitol and their properties
  作者：Jie Xia、Yong-Zheng Hui

  DOI：10.1016/s0957-4166(97)00341-8

  日期：1997.9

  The synthesis of the novel ether phospholipids from D-mannitol as homochiral material using a new method for the removal of a tert-butyldimethylsilyl group for hydroxyl protection without acyl migration and their properties including bioactivity are described. (C) 1997 Elsevier Science Ltd.
• LIPID-BASED DRUG DELIVERY SYSTEMS FOR TOPICAL APPLICATION
  申请人：Liplasome Pharma A/S

  公开号：EP1272160A2

  公开（公告）日：2003-01-08
• [EN] LIPID-BASED DRUG DELIVERY SYSTEMS CONTAINING PHOSPHOLIPASE A2 DEGRADABLE LIPID DERIVATIVES FOR TOPICAL APPLICATION TO THE SKIN<br/>[FR] SYSTEMES D'ADMINISTRATION DE MEDICAMENTS A BASE DE LIPIDES CONTENANT DES DERIVES LIPIDIQUES DEGRADABLES DE PHOSPHOLIPASE A2 DESTINES A L'APPLICATION TOPIQUE A LA PEAU
  申请人：LIPLASOME PHARMA AS

  公开号：WO2001076555A2

  公开（公告）日：2001-10-18

  The invention relates to lipid-based pharmaceutical or cosmetic compositions for use in the treatment, prevention or alleviation of diseases or conditions in skin or mucous membranes of mammals that are associated with or resulting from increased levels of extracellular phospholipase A2 (PLA2) activity in the tissue.