[2-(4-hydroxy-phenyl)-2-(R)-methoxy-ethyl]carbamic acid benzyl ester | 851714-37-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-(4-hydroxy-phenyl)-2-(R)-methoxy-ethyl]carbamic acid benzyl ester
• 英文别名: [2-(4-hydroxy-phenyl)-2-(R)-methoxy-ethyl]-carbamic acid benzyl ester；benzyl N-[(2R)-2-(4-hydroxyphenyl)-2-methoxyethyl]carbamate
• CAS: 851714-37-9
• 化学式: C₁₇H₁₉NO₄
• 分子量: 301.342
• InChiKey: JIZWGVPXCSFJLV-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [2-(4-hydroxy-phenyl)-2-(R)-methoxy-ethyl]carbamic acid benzyl ester 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、101.32 kPa 条件下， 反应 8.0h， 以85%的产率得到4-[(1R)-2-amino-1-methoxyethyl]phenol
  参考文献：
  名称：

  Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells

  摘要：

  The selective induction of death in cancer cells is a major challenge in modern medicine. In this communication we describe the synthesis of an 88-membered combinatorial library, and the subsequent evaluation of these compounds for their ability to selectively induce apoptosis in cancerous cells. A compound was identified from the library that induces apoptosis in U-937 and HL-60 cell lines. This compound is a remarkably selective pro-apoptotic agent for these cancer cell lines, as it does not induce significant death in noncancerous white blood cells, even at concentrations as high as 1000 muM.

  DOI：

  10.1021/ja038043d
• 作为产物：
  描述：

  acetic acid 4-(2-benzyloxycarbonylamino-1-(R)-methoxyethyl)phenyl ester 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以92%的产率得到[2-(4-hydroxy-phenyl)-2-(R)-methoxy-ethyl]carbamic acid benzyl ester
  参考文献：
  名称：

  Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells

  摘要：

  The selective induction of death in cancer cells is a major challenge in modern medicine. In this communication we describe the synthesis of an 88-membered combinatorial library, and the subsequent evaluation of these compounds for their ability to selectively induce apoptosis in cancerous cells. A compound was identified from the library that induces apoptosis in U-937 and HL-60 cell lines. This compound is a remarkably selective pro-apoptotic agent for these cancer cell lines, as it does not induce significant death in noncancerous white blood cells, even at concentrations as high as 1000 muM.

  DOI：

  10.1021/ja038043d

文献信息

• Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells
  申请人：Hergenrother J. Paul

  公开号：US20050197511A1

  公开（公告）日：2005-09-08

  Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. The generation of synthetic combinatorial libraries and the evaluation of library member compounds regarding induction of apoptosis selectively in cancer cells are disclosed. Compounds, methods of making the compounds, and therapeutic methods with application against breast cancer cells, melanoma cancer cells, colon cancer cells, and other cancer cells are described.

  本文披露了合成化合物及相关方法，并使用化合物和联合疗法治疗癌症和调节细胞凋亡。本文还披露了合成组合库的生成以及评估库成员化合物在选择性诱导癌细胞凋亡方面的应用。描述了化合物、制备化合物的方法以及应用于乳腺癌细胞、黑色素瘤癌细胞、结肠癌细胞和其他癌症细胞的治疗方法。
• [EN] COMPOUNDS AND METHODS FOR TREATMENT OF CANCER AND MODULATION OF PROGRAMMED CELL DEATH FOR MELANOMA AND OTHER CANCER CELLS<br/>[FR] COMPOSES ET PROCEDES DE TRAITEMENT DU CANCER ET MODULATION DE LA MORT CELLULAIRE PROGRAMMEE DE MELANOMES ET D'AUTRES CELLULES CANCEREUSES
  申请人：UNIV ALABAMA

  公开号：WO2005044191A3

  公开（公告）日：2005-10-20
• US7632972B2
  申请人：——

  公开号：US7632972B2

  公开（公告）日：2009-12-15