8-(3-phenothiazin-10-yl-propyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one | 58012-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 8-(3-phenothiazin-10-yl-propyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
• 英文别名: 8-(3-Phenothiazin-10-ylpropyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
• CAS: 58012-09-2
• 化学式: C₂₈H₃₀N₄OS
• 分子量: 470.638
• InChiKey: QERSUXOOSQLXJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吩噻嗪 在 sodium hydride 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 生成 8-(3-phenothiazin-10-yl-propyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
  参考文献：
  名称：

  Identification of a non peptidic RANTES antagonist

  摘要：

  A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC50=3 mu M) was found to inhibit specific binding of I-125-RANTES, but not I-125-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00094-8

文献信息

• Identification of a non peptidic RANTES antagonist
  作者：Colin Bright、Thomas J. Brown、Paul Cox、Frank Halley、Peter Lockey、Iain M. McLay、Una Moore、Barry Porter、Robert J. Williams

  DOI：10.1016/s0960-894x(98)00094-8

  日期：1998.4

  A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC50=3 mu M) was found to inhibit specific binding of I-125-RANTES, but not I-125-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells. (C) 1998 Elsevier Science Ltd. All rights reserved.