4-hydroxy-N,N-dimethyl-3-nitrobenzenesulfonamide | 42247-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-hydroxy-N,N-dimethyl-3-nitrobenzenesulfonamide
• 英文别名: N,N-dimethyl-2-nitro-1-phenol-4-sulfonamide；4-N,N-Dimethylsulfonamid-2-nitrophenol
• CAS: 42247-91-6
• 化学式: C₈H₁₀N₂O₅S
• mdl: MFCD11185144
• 分子量: 246.244
• InChiKey: WSOMANNJPFZGIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-hydroxy-N,N-dimethyl-3-nitrobenzenesulfonamide 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 以68%的产率得到N-N-二甲基-3-氨基-4-羟基-1-苯磺酰胺
  参考文献：
  名称：

  Synthesis and quantitative structure-activity relationships of antiallergic 2-hydroxy-N-(1H-tetrazol-5-yl)benzamides and N-(2-hydroxyphenyl)-1H-tetrazole-5-carboxamides

  摘要：

  The synthesis and antiallergic activity of a series of 2-hydroxy-N-1H-tetrazol-5-ylbenzamides and isomeric N-(2-hydroxyphenyl)-1H-tetrazole-5-carboxamides is described. A relationship between structure and intravenous antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test has been established using a Hansch/Free-Wilson model and used to direct studies toward potent derivatives. The contribution of physicochemical properties to activity is discussed. One member of this series, N-(3-acetyl-5-fluoro-2-hydroxyphenyl)-1H-tetrazole-5-carboxamide (3f), which was selected for further evaluation, has an ID50 value of 0.16 mg/kg po and is 130 times more potent than disodium cromoglycate (DSCG) on intravenous administration.

  DOI：

  10.1021/jm00154a019
• 作为产物：
  描述：

  4-羟基-N,N-二甲基苯磺酰胺 在 硝酸 作用下， 以 硫酸 为溶剂， 以7.85 grams (63.8%)的产率得到4-hydroxy-N,N-dimethyl-3-nitrobenzenesulfonamide
  参考文献：
  名称：

  Sulfonamido herbicidal compositions and plant control methods using the

  摘要：

  本发明涉及新型取代-1-苯酚-4-磺胺酰胺及其盐。它还涉及一种用于利用该化合物控制不良植物物种的方法，特别是一种通过将该化合物的种子或叶片与野燕麦植物接触以选择性控制野燕麦的新方法，该方法具有除草效果。

  公开号：

  US03979203A1

文献信息

• [EN] 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS<br/>[FR] 1H-PYRROLO [2,3-C] PYRIDINE -7(6H)-ONES ET PYRAZOLO[3,4-C]PYRIDINE-7(6H)-ONES EN TANT QU'INHIBITEURS DE PROTÉINES BET
  申请人：INCYTE CORP

  公开号：WO2015164480A1

  公开（公告）日：2015-10-29

  The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

  本发明涉及取代吡咯吡啶酮和取代吡唑吡啶酮，它们是BET蛋白（如BRD2、BRD3、BRD4和BRD-t）的抑制剂，并且在治疗癌症等疾病中具有用途。
• Sulfonamido herbicidal compositions and plant control methods using the
  申请人：American Cyanamid Company

  公开号：US03979203A1

  公开（公告）日：1976-09-07

  The present invention relates to novel substituted-1-phenol-4-sulfonamides and salts thereof. It also relates to a method for controlling undesirable plant species with said compounds, and particularly to a novel method for selectively controlling wild oats with said compounds by contacting the seeds or foliage of said wild oat plants with a herbicidally effective amount thereof.

  本发明涉及新型取代-1-苯酚-4-磺胺酰胺及其盐。它还涉及一种用于利用该化合物控制不良植物物种的方法，特别是一种通过将该化合物的种子或叶片与野燕麦植物接触以选择性控制野燕麦的新方法，该方法具有除草效果。
• 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS
  申请人：Incyte Corporation

  公开号：US20170158689A1

  公开（公告）日：2017-06-08

  The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

  本发明涉及取代的吡咯吡啶酮和取代的吡唑吡啶酮，它们是BET蛋白的抑制剂，如BRD2，BRD3，BRD4和BRD-t，并且在治疗癌症等疾病方面有用。
• 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
  申请人：Incyte Corporation

  公开号：US10472358B2

  公开（公告）日：2019-11-12

  The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

  本发明涉及取代的吡咯并吡啶酮和取代的吡唑并吡啶酮，它们是 BET 蛋白如 BRD2、BRD3、BRD4 和 BRD-t 的抑制剂，可用于治疗癌症等疾病。
• FORD, E.;KNOWLES, PH.;LUNT, E.;MARSHALL, S. M.;PENROSE, A. J.;RAMSDEN, A.+, J. MED. CHEM., 1986, 29, N 4, 538-549
  作者：FORD, E.、KNOWLES, PH.、LUNT, E.、MARSHALL, S. M.、PENROSE, A. J.、RAMSDEN, A.+

  DOI：——

  日期：——