扁桃酸酰肼 | 67258-45-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 扁桃酸酰肼
• 英文名称: mandelic acid hydrazide
• 英文别名: N-Phenylmandelohydrazid；mandelic acid-(N'-phenyl-hydrazide)；Mandelsaeure-(N'-phenyl-hydrazid)；2-hydroxy-N',2-diphenylacetohydrazide
• CAS: 67258-45-1
• 化学式: C₁₄H₁₄N₂O₂
• 分子量: 242.277
• InChiKey: MAXMTGOFWOPHBW-UHFFFAOYSA-N

物化性质

• 熔点：
  181-183 °C(Solv: ethanol (64-17-5))
• 沸点：
  387.6±42.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  扁桃酸酰肼 在 potassium nitrite 、 硫酸 作用下， 生成 mandelic acid-(N'-nitroso-N'-phenyl-hydrazide)
  参考文献：
  名称：

  Reissert; Kayser, Chemische Berichte, 1890, vol. 23, p. 3702

  摘要：

  DOI：
• 作为产物：
  描述：

  2-oxo-2-phenyl-1-phenylhydrazono-ethanesulfonic acid 在 钾硼氢 作用下， 生成 扁桃酸酰肼
  参考文献：
  名称：

  304.用碱金属硼氢化物还原某些α-苯基肼基酮

  摘要：

  DOI：

  10.1039/jr9570001583

文献信息

• Famoxadone: the discovery and optimisation of a new agricultural fungicide
  作者：Jeffrey A Sternberg、Detlef Geffken、John B Adams、Reiner P�stages、Charlene G Sternberg、Carlton L Campbell、William K Moberg

  DOI：10.1002/1526-4998(200102)57:2<143::aid-ps282>3.0.co;2-8

  日期：2001.2

  Famoxadone (3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione), is a new agricultural fungicide recently commercialized by DuPont under the trade name Famoxate(R) Famoxadone is a member of a new class of oxazolidinone fungicides that demonstrate excellent control of plant pathogens in the Ascomycete, Basidiomycete, and Oomycete classes that infect grapes, cereals, tomatoes, potatoes and other crops. DuPont's entry into the oxazolidinone area resulted from the procurement of 5-methyl-5-phenyl-3-phenylamino-2-thioxo-4-oxazolidinone (1) from Professor Detlef Geffken, then at the University of Bonn, An extensive analog program was initiated immediately after the fungicidal activity of 1 was discovered through routine greenhouse testing. The discovery program in the oxazolidinone area eventually culminated in the advancement of famoxadone to commercial development in the early 1990s. The synthesis of various oxazolidinone ring systems and the development of the structure-activity relationships that led to the discovery of famoxadone are described. (C) 2001 Society of Chemical Industry.
• Lobry de Bruyn; van Ekenstein, Recueil des Travaux Chimiques des Pays-Bas, 1902, vol. 21, p. 316
  作者：Lobry de Bruyn、van Ekenstein

  DOI：——

  日期：——
• IMPACT OF POSITIVE SURGICAL MARGINS ON PROSTATE CANCER RECURRENCE AND THE USE OF SECONDARY CANCER TREATMENT: DATA FROM THE CAPSURE DATABASE
  作者：GARY D. GROSSFELD、JAMES J. CHANG、JEANETTE M. BROERING、DAVE P. MILLER、JENNY YU、SCOTT C. FLANDERS、JAMES M. HENNING、DAVID M. STIER、PETER R. CARROLL

  DOI：10.1016/s0022-5347(05)67716-6

  日期：2000.4

  Purpose: We determined the impact of positive surgical margins on prostate specific antigen (PSA) recurrence and secondary treatment in patients who underwent radical prostatectomy as definitive local treatment for prostate cancer.Materials and Methods: We reviewed the pathology reports of 1,383 patients in the CaPSURE* database, a longitudinal disease registry of men with prostate cancer, who underwent radical prostatectomy as definitive local treatment. Pathological stage, Gleason score, and the number and location of any positive surgical margins were determined in each patient. PSA recurrence was defined as PSA 0.2 ng./ml. or greater on 2 consecutive occasions after radical prostatectomy. Secondary cancer treatment consisted of radiation or androgen deprivation after radical prostatectomy. Adjuvant and nonadjuvant secondary treatment was given within and more than 6 months after radical prostatectomy, respectively. Kaplan-Meier event rates of PSA recurrence and secondary treatment were calculated for patients with positive and negative surgical margins. We performed multivariate Cox proportional hazards analysis to adjust for clinical differences in groups.Results: Patients with positive surgical margins were significantly more likely to undergo secondary adjuvant or nonadjuvant cancer treatment and have PSA recurrence than those with negative margins. After adjusting for patient age, ethnicity, PSA at diagnosis, pathological stage and Gleason score, surgical margin status was an important independent predictor of PSA recurrence and secondary treatment (p = 0.06 and 0.0011, respectively). The number of positive margins and positive margin location had little impact on the outcomes measured.Conclusions: These data indicate that surgical margin status is an independent predictor of PSA recurrence and secondary cancer treatment in patients who underwent radical prostatectomy as definitive local therapy for prostate cancer.
• Reissert; Kayser, Chemische Berichte, 1889, vol. 22, p. 2928
  作者：Reissert、Kayser

  DOI：——

  日期：——
• Reissert; Kayser, Chemische Berichte, vol. 23, p. 3702
  作者：Reissert、Kayser

  DOI：——

  日期：——