phenyl 2-benzyloxypropionate | 143088-70-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: phenyl 2-benzyloxypropionate
• 英文别名: Phenyl-O-benzyllactat；Phenyl 2-phenylmethoxypropanoate
• CAS: 143088-70-4
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.301
• InChiKey: JNPZEKZPIMORBH-UHFFFAOYSA-N

物化性质

• 沸点：
  367.8±25.0 °C(Predicted)
• 密度：
  1.126±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenyl 2-benzyloxypropionate 在 tin(II) trifluoromethanesulfonate 、 (S)-1-methyl-2-<(N-naphthylamino)methyl>pyrrolidine 、 二乙酸二丁基锡 、 lithium diisopropyl amide 作用下， 反应 20.5h， 生成 (E)-2-Benzyloxy-3-hydroxy-2-methyl-hex-4-enoic acid phenyl ester
  参考文献：
  名称：

  外消旋化合物不对称合成制备手性合成子的有效方法

  摘要：

  旋光α-烷氧基-α-甲基-β-羟基酯衍生物由外消旋α-烷氧基丙酸酯衍生物通过相应非手性中间体的不对称羟醛反应制备。(-)-2-C-Methyl-D-threono-1,4-lactone 可以使用这种方法方便地合成。

  DOI：

  10.1246/cl.1992.373
• 作为产物：
  描述：

  2-benzyloxy-propionyl chloride 、 苯酚 生成 phenyl 2-benzyloxypropionate
  参考文献：
  名称：

  乳酸的苯基酯。

  摘要：

  DOI：

  10.1021/jm00308a065

文献信息

• FUNCTIONALIZED PHENOLIC COMPOUNDS AND POLYMERS THEREFROM
  申请人：Bezwada Rao S.

  公开号：US20090170927A1

  公开（公告）日：2009-07-02

  The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X) p —R′] q I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

  本发明涉及公式I的化合物，这些化合物是官能化酚类化合物，以及由它们形成的聚合物。从官能化酚类化合物形成的聚合物预计具有可控的降解特性，使它们能够在所需的时间范围内释放活性成分。这些聚合物还预计在各种医疗应用中有用。
• FUNCTIONALIZED DIPHENOLICS AND ABSORBABLE POLYMERS THEREFROM
  申请人：Bezwada S Rao

  公开号：US20070135355A1

  公开（公告）日：2007-06-14

  The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

  本发明涉及去酚化合物，以下是一个示例，这些化合物被官能化，并且形成的聚合物。从官能化二酚形成的聚合物预计具有可控的降解特性，使它们能够在所需的时间范围内释放活性成分。这些聚合物也预计在各种医疗应用中有用。
• DIFUNCTIONALIZED AROMATIC COMPOUNDS AND POLYMERS THEREFROM
  申请人：Bezwada Rao S.

  公开号：US20110313057A1

  公开（公告）日：2011-12-22

  The present invention relates to compounds of formula I, which are difunctionalized aromatic compounds, and polymers formed from the same. [R′—(X) a —OC(O)] p —Ar—[NR′—(Y) b —R′] q I Polymers formed from the difunctionalized aromatics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

  本发明涉及公式I的化合物，它们是二官能芳香族化合物，以及由它们形成的聚合物。从二官能芳香族化合物形成的聚合物预计具有可控的降解特性，使它们能够在所需的时间范围内释放活性成分。这些聚合物也预计在各种医疗应用中有用。
• BIOABSORBABLE AND BIOCOMPATIBLE POLYURETHANES AND POLYAMIDES FOR MEDICAL DEVICES
  申请人：Bezwada Rao S.

  公开号：US20120158127A1

  公开（公告）日：2012-06-21

  Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the corresponding diamines or diisocyanates thereof, wherein each X independently represents —CH 2 COO—, —CH(CH 3 )COO—, —CH 2 CH 2 OCH 2 COO—, —CH 2 CH 2 CH 2 CH 2 CH 2 COO—, —(CH 2 ) y COO— where y is 2 to 4 or 6 to 24, or —(CH 2 CH 2 O) z′ CH 2 COO— where z′ is 2 to 24; each Y represents —COCH 2 O—, —COCH(CH 3 )O—, —COCH 2 OCH 2 CH 2 O—, —COCH 2 CH 2 CH 2 CH 2 CH 2 O—, —CO(CH 2 ) m O— where m is 2 to 4 or 6 to 24, or —COCH 2 O(CH 2 CH 2 O) n — where n is 2 to 24; R′ is hydrogen, benzyl or straight-chained or branched alkyl; p is 1 to 4; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO 2 , which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.

  可吸收的聚氨酯、聚酰胺和聚酯尿素是由至少一种选择自以下化合物或其相应的二胺或二异氰酸酯制备而成：其中每个X独立地表示-CH2COO-、-CH(CH3)COO-、-CH2CH2OCH2COO-、-CH2CH2CH2CH2CH2COO-、-(CH2)yCOO-，其中y为2至4或6至24，或-(CH2CH2O)z'CH2COO-，其中z'为2至24；每个Y表示-COCH2O-、-COCH(CH3)O-、-COCH2OCH2CH2O-、-COCH2CH2CH2CH2CH2O-、-CO(CH2)mO-，其中m为2至4或6至24，或-COCH2O(CH2CH2O)n-，其中n为2至24；R'为氢、苄基或直链或支链烷基；p为1至4；Rn表示选择自H、烷氧基、苄氧基、醛、卤素、羧酸和-NO2的一个或多个成员，它直接附着在芳香环上或通过脂肪链附着。从这些化合物制备的可吸收聚合物可用于药物输送、组织工程、组织粘合剂、粘着预防和其他可植入医疗器械。
• FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM
  申请人：Bezwada Rao S.

  公开号：US20120094994A1

  公开（公告）日：2012-04-19

  The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

  本发明涉及式I和II的化合物，它们是功能化氨基酸，以及由它们形成的聚合物。由功能化氨基酸形成的聚合物预计具有可控的降解特性，使它们能够在所需的时间范围内释放活性成分。这些聚合物也预计在各种医疗应用中有用。