2-hydroxy-benzenesulfonic acid anilide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-benzenesulfonic acid anilide
• 英文别名: 2-Hydroxy-benzolsulfonsaeure-anilid；o-Phenolsulfonsaeure-anilid；2-hydroxy-N-phenylbenzenesulfonamide
• 化学式: C₁₂H₁₁NO₃S
• mdl: MFCD21896555
• 分子量: 249.29
• InChiKey: AZJJLYHWUHESOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-N-苯基苯磺酰胺 在 盐酸 、 溶剂黄146 、 sodium nitrite 作用下， 生成 2-hydroxy-benzenesulfonic acid anilide
  参考文献：
  名称：

  Ullmann; Gross, Chemische Berichte, 1910, vol. 43, p. 2700

  摘要：

  DOI：

文献信息

• Visible-light-induced arylation<i>via</i>an electron–donor–acceptor complex: a catalyst-free approach for the synthesis of<i>N</i>-(hetero)aryl sulfonamides
  作者：Arsala Kamal、Vandana Srivastava、Sundaram Singh

  DOI：10.1039/d3nj02224b

  日期：——

  photoexcitation of aryl(hetero)diazonium salts and sulfonamides enabled this strategy under visible-light irradiation through an EDA complex used to carry out a one-step synthesis without a catalyst. This approach tolerated various functional groups of primary sulfonamides and (hetero)aryl diazonium salts, frequently found in modern medications and pharmacological intermediates. This method also enabled

  在制药领域，功能化芳基磺酰胺是基本组成部分。芳基（杂）重氮盐和磺酰胺的光激发通过 EDA 复合物在可见光照射下实现了这一策略，该复合物用于在没有催化剂的情况下进行一步合成。这种方法可以耐受现代药物和药理中间体中常见的伯磺酰胺和（杂）芳基重氮盐的各种官能团。该方法还能够实现仲磺酰胺的直接芳基化。机理研究表明，形成的电子给体受体EDA复合物和磺酰胺自由基通过自由基偶联与芳基自由基中间体快速相互作用，生成所需产物。
• 5-AMINOACETYLAMINOSULFONANILIDE COMPOUND
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0685461A1

  公开（公告）日：1995-12-06

  An object of the invention is to provide a drug which is reduced in the side effects such as digestive tract disorder, has such a high safety as to permit long-term administration, and has anti-inflammatory, antipyretic, analgesic and and antiallergic activities. The drug comprises a compound represented by general formula (I) or a salt thereof, wherein R¹ represents phenyl, halophenyl or C₃-C₈ cycloalkyl; R² represents hydrogen or C₁-C₅ alkyl; and R³ represents hydrogen, C₁-C₇ alkyl, C₃-C₈ cycloalkyl, C₃-C₅ alkenyl or benzyl; or alternatively R² and R³ are combined together to represents a 5- to 7- membered heterocyclic group in combination with the nitrogen atom to which they are bonded.

  本发明的目的是提供一种药物，该药物副作用小，如消化道紊乱，安全性高，可长期服用，并具有抗炎、解热、镇痛和抗过敏活性。该药物包括通式（I）代表的化合物或其盐，其中 R¹ 代表苯基、卤代苯基或 C₃-C₈ 环烷基；R² 代表氢或 C₁-C₅ 烷基；和 R³ 代表氢、C₁-C₇ 烷基、C₃-C₈ 环烷基、C₃-C₅ 烯基或苄基；或者，R² 和 R³ 结合在一起代表 5-7 位杂环基团，并与氮原子结合。
• Anschuetz, Justus Liebigs Annalen der Chemie, 1918, vol. 415, p. 93
  作者：Anschuetz

  DOI：——

  日期：——
• 5-AMINO-2-PHENOXYSULFONANILIDE COMPOUND
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0645374B1

  公开（公告）日：1996-11-20
• CELLULOSE ESTER FILM, POLARIZER AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：Takeda Jun

  公开号：US20090317567A1

  公开（公告）日：2009-12-24

  A cellulose ester film with Rth>0 nm comprising a cellulose ester having a total degree of substitution of at least 2.3 and a polymer X with a weight-average molecular weight of 500-100000 satisfying 30%≦A≦100%, wherein A indicates the polymerization ratio of a monomer whose homopolymer has a negative birefringence, is excellent in humidity stability and wet heat durability.