(E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole | 1350920-04-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole
• 英文别名: 2-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole
• CAS: 1350920-04-5
• 化学式: C₁₉H₁₅F₃N₂O₃
• 分子量: 376.335
• InChiKey: MDCRYADDJODABC-ONNFQVAWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  57.4
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-(三氟甲基)亚苯基肼 在 copper(l) iodide 、 lithium tert-butoxide 、 N,N'-二甲基乙二胺 作用下， 以 二甲基亚砜 为溶剂， 反应 3.0h， 生成 (E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole
  参考文献：
  名称：

  Copper-catalyzed direct cross coupling of 1,3,4-oxadiazoles with trans-β-halostyrenes: synthesis of 2-E-vinyl 1,3,4-oxadiazoles

  摘要：

  The first direct C-H alkenylation of 1,3,4-oxadiazoles with trans-beta-halo olefinic system has been carried out using a combination of Cul/DMEDA as a catalyst. A wide range of 2-E-vinyl-substituted oxadiazoles were obtained in high yields (85-93%). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.10.049

文献信息

• Copper-catalyzed direct cross coupling of 1,3,4-oxadiazoles with trans-β-halostyrenes: synthesis of 2-E-vinyl 1,3,4-oxadiazoles
  作者：Biswanath Das、Gandolla Chinna Reddy、Penagaluri Balasubramanyam、N. Salvanna

  DOI：10.1016/j.tet.2011.10.049

  日期：2012.1

  The first direct C-H alkenylation of 1,3,4-oxadiazoles with trans-beta-halo olefinic system has been carried out using a combination of Cul/DMEDA as a catalyst. A wide range of 2-E-vinyl-substituted oxadiazoles were obtained in high yields (85-93%). (C) 2011 Elsevier Ltd. All rights reserved.