methyl 2,5-dihydroxy-4-methoxybenzoate | 13618-45-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2,5-dihydroxy-4-methoxybenzoate
• 英文别名: 2,5-Dihydroxy-4-methoxy-benzoesaeure-methylester；Methyl-2,5-dihydroxy-4-methoxybenzoat
• CAS: 13618-45-6
• 化学式: C₉H₁₀O₅
• 分子量: 198.175
• InChiKey: QPFXZHDNFHBICB-UHFFFAOYSA-N

物化性质

• 熔点：
  95 °C
• 沸点：
  381.3±37.0 °C(Predicted)
• 密度：
  1.337±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 2,5-dihydroxy-4-methoxybenzoate 在 potassium carbonate 、 silver(l) oxide 作用下， 生成 syn-cis-1,4,4a,5,8,8a-Hexahydro-4a-methoxycarbonyl-2,6-dimethoxy-5,7-dimethylnaphthalin-dion-(1,4)
  参考文献：
  名称：

  558.核磁共振光谱法在对苯醌的狄尔斯-阿尔德加合物中的应用

  摘要：

  DOI：

  10.1039/jr9630003036
• 作为产物：
  描述：

  在 硫酸 作用下， 以 甲醇 为溶剂， 生成 methyl 2,5-dihydroxy-4-methoxybenzoate
  参考文献：
  名称：

  Oida,S. et al., Chemical and pharmaceutical bulletin, 1973, vol. 21, p. 528 - 537

  摘要：

  DOI：

文献信息

• Dual Behavior of Masked <i>o</i>-Benzoquinones in Intramolecular Diels−Alder Reactions. Expedient Synthesis of Highly Functionalized <i>cis</i>-Decalins from 2-Methoxyphenols
  作者：Po-Yi Hsu、Rama Krishna Peddinti、Santhosh Kumar Chittimalla、Chun-Chen Liao

  DOI：10.1021/jo0510179

  日期：2005.11.1

  added 2,4-dienol. The majority of the cycloadducts resulted from the diene property of MOBs in intramolecular Diels−Alder reactions smoothly underwent Cope rearrangement to furnish cis-decalins as sole products in excellent to quantitative yields that provides a short and efficient entry to polyfunctionized cis-decalins from 2-methoxyphenols. Furthermore, the variation of dienophilic and diene characters

  潜在的双重行为作为掩蔽的二烯部分的二烯和亲双烯体ö -benzoquinones（MOBS）10A - ë - 12A - ë，在2-甲氧基苯酚氧化产生1 - 3中的适当dienols存在下与BTIB，在其分子内Diels-Alder（IMDA）反应已经过检查。MOB 10a - d，11a，b，d和12a，b，d的IMDA反应导致高度官能化的草三环化合物18a - d，图19A，b，d，和20A，b，d分别与伴随形成的顺式-decalin衍生物21a的- d，22A，b，d，和23A，b，d的高度区域选择性和立体选择性的方式。但是，MOB 10e - 12e仅提供草三环化合物18e - 20e。顺式的形成这些IMDA反应中的十氢化萘除了具有二烯的作用外，还表明了MOB的亲二烯性。由于MOB的双重特征，在每个反应中获得的两个环加合物的比例取决于环己二烯酮部分和所添加的2，4-二烯醇两者上的
• Switchable Reactivity of Cyclopropane Diesters toward (3 + 3) and (3 + 2) Cycloadditions with Benzoquinone Esters
  作者：Navpreet Kaur、Pankaj Kumar、Arijit Hazra、Prabal Banerjee

  DOI：10.1021/acs.orglett.2c03446

  日期：2022.11.11

  Herein, we describe an unprecedented (3 + 3) cycloaddition reaction of the donor–acceptor cyclopropanes with quinone esters toward the construction of chroman scaffolds in moderate to good yields. Interestingly, the strategy is also adjustable toward a (3 + 2) cycloaddition by just switching the Lewis acid to furnish benzofuran scaffolds. Based on the choice of Lewis acid used, the same set of precursors

  在此，我们描述了一种前所未有的供体-受体环丙烷与醌酯的 (3 + 3) 环加成反应，以中等至良好的收率构建色满支架。有趣的是，该策略还可以调整为 (3 + 2) 环加成，只需切换路易斯酸来提供苯并呋喃支架。根据所用路易斯酸的选择，同一组前体已用于递送苯并吡喃和苯并呋喃衍生物。
• THERMALLY CURABLE EPOXY-AMINE BARRIER SEALANTS
  申请人：National Starch and Chemical Investment Holding Corporation

  公开号：EP2001924A1

  公开（公告）日：2008-12-17
• IMPROVED WORK TIME TO WALK-ON TIME RATIO BY ADDING A PHENOLIC CATALYST TO POLYASPARTIC FLOORING FORMULATIONS
  申请人：Covestro LLC

  公开号：EP4004076A1

  公开（公告）日：2022-06-01
• WORK TIME TO WALK-ON TIME RATIO BY ADDING A PHENOLIC CATALYST TO POLYASPARTIC FLOORING FORMULATIONS
  申请人：COVESTRO LLC

  公开号：US20210032407A1

  公开（公告）日：2021-02-04

  The present invention provides a polyaspartic composition comprising a reaction product of a polyamine and a Michael addition receptor reacted in the presence of a catalyst comprising a phenolic compound, with the proviso that the phenolic compound is not a phenol which is substituted with tert-butyl groups in both ortho positions to the oxygen. Suitable phenolic compounds include phenols, phenolic aldehydes, alkylphenols, benzenediols, cashew nut oil, and combinations thereof. Coatings, adhesives, sealants, composites, castings, and films comprising a polyurea composition may be made by reacting a polyisocyanate with the inventive polyaspartic composition. In particular, floor coatings made with the inventive polyaspartic composition have an elongated work time and a short walk-on time compared to current floor coatings.