2,3-bis-(3-hydroxy-1-propynyl)naphthalene | 220316-72-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,3-bis-(3-hydroxy-1-propynyl)naphthalene
• CAS: 220316-72-3
• 化学式: C₁₆H₁₂O₂
• 分子量: 236.27
• InChiKey: GHNNBAQTLNNWBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.53
• 重原子数：
  18.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  40.46
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2,3-bis-(3-hydroxy-1-propynyl)naphthalene 在 sodium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.5h， 生成 2,3-bis-(3-phenylthiopropynyl)naphthalene
  参考文献：
  名称：

  Synthesis and Biological Activities of Aryl Propargyl Sulfone

  摘要：

  AbstractA series of molecules containing monopropargyl sulfone or 1, 2‐bis‐propargyl sulfone were synthesized. The cytotoxicity of these compounds against human carcinoma cells was also examined. This study indicated that the formation of a biradical intermediate is important to the potency of cytotoxicity.

  DOI：

  10.1002/jccs.199800118
• 作为产物：
  描述：

  儿茶酚二(三氟甲烷磺酸酯) 、 2-丙炔-1-醇 在 copper(l) iodide 、 四(三苯基膦)钯 、 正丁胺 作用下， 以 乙醚 为溶剂， 反应 5.0h， 以52%的产率得到2,3-bis-(3-hydroxy-1-propynyl)naphthalene
  参考文献：
  名称：

  Synthesis and Biological Activities of Aryl Propargyl Sulfone

  摘要：

  AbstractA series of molecules containing monopropargyl sulfone or 1, 2‐bis‐propargyl sulfone were synthesized. The cytotoxicity of these compounds against human carcinoma cells was also examined. This study indicated that the formation of a biradical intermediate is important to the potency of cytotoxicity.

  DOI：

  10.1002/jccs.199800118

文献信息

• Synthesis and Biological Activities of Aryl Propargyl Sulfone
  作者：Ming-Jung Wu、Chi-Fong Lin、Li-Juan Chang、Pao-Tzu Jing、Tsai-Hui Duh、Wuan-Ting Tseng、Fang-Chen Lee、Shan-Shue Wang、Hsueh-O Chang

  DOI：10.1002/jccs.199800118

  日期：1998.12

  AbstractA series of molecules containing monopropargyl sulfone or 1, 2‐bis‐propargyl sulfone were synthesized. The cytotoxicity of these compounds against human carcinoma cells was also examined. This study indicated that the formation of a biradical intermediate is important to the potency of cytotoxicity.
• Allene-Eneyne Related Cycloaromatization: Design and Synthesis of New DNA-Cleaving Compounds
  作者：Ming-Jung Wu、Chi-Fong Lin、Pao-Tzu Jing、Li-Juan Chang、Tsai-Hui Duh、Fang-Chen Lee、Huey-Ting Chen

  DOI：10.1002/jccs.199800072

  日期：1998.8

  Abstract(Z)‐7‐Sulfonyl‐3‐hexen‐1,5‐diyne containing molecules are stable at room temperature and isomerized to eneyne‐allene‐sulfones under alkaline conditions. These eneyne‐allene‐sulfones were not isolable, spontaneously cyclized to form biradical intermediates under mild conditions, and exhibited good DNA‐cleaving and human tumor cell line growth inhibition properties. Further studies indicated that compounds bearing on aromatic ring at C(3) and C(4), such as 25, proved to be more active against those tumor cell lines. Removal of acetylene unit at C(1) and C(2), made the resulting compound less active. A related compound, (Z,Z)‐12‐(2‐tetrahydropyranyl)oxy‐1‐phenylsulfonyldodeca‐4,8‐diene‐2,6,10‐triyne (37), was synthesized. Upon treatment of triethylamine at refluxing benzene, this compound undergoes double cycloaromatization to form a naphalene adduct, which possesses excellent DNA‐cleaving activity.