2,3-bis-(3-phenylthiopropynyl)naphthalene | 220316-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,3-bis-(3-phenylthiopropynyl)naphthalene
• CAS: 220316-73-4
• 化学式: C₂₈H₂₀S₂
• 分子量: 420.599
• InChiKey: QDFQHGLCIMGQAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.13
• 重原子数：
  30.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2,3-bis-(3-phenylthiopropynyl)naphthalene 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以43%的产率得到2,3-bis-(3-phenylsulfonylpropynyl)naphthalene
  参考文献：
  名称：

  Allene-Eneyne Related Cycloaromatization: Design and Synthesis of New DNA-Cleaving Compounds

  摘要：

  Abstract(Z)‐7‐Sulfonyl‐3‐hexen‐1,5‐diyne containing molecules are stable at room temperature and isomerized to eneyne‐allene‐sulfones under alkaline conditions. These eneyne‐allene‐sulfones were not isolable, spontaneously cyclized to form biradical intermediates under mild conditions, and exhibited good DNA‐cleaving and human tumor cell line growth inhibition properties. Further studies indicated that compounds bearing on aromatic ring at C(3) and C(4), such as 25, proved to be more active against those tumor cell lines. Removal of acetylene unit at C(1) and C(2), made the resulting compound less active. A related compound, (Z,Z)‐12‐(2‐tetrahydropyranyl)oxy‐1‐phenylsulfonyldodeca‐4,8‐diene‐2,6,10‐triyne (37), was synthesized. Upon treatment of triethylamine at refluxing benzene, this compound undergoes double cycloaromatization to form a naphalene adduct, which possesses excellent DNA‐cleaving activity.

  DOI：

  10.1002/jccs.199800072
• 作为产物：
  描述：

  儿茶酚二(三氟甲烷磺酸酯) 在 sodium hydroxide 、 copper(l) iodide 、 四(三苯基膦)钯 、 正丁胺 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 8.5h， 生成 2,3-bis-(3-phenylthiopropynyl)naphthalene
  参考文献：
  名称：

  Synthesis and Biological Activities of Aryl Propargyl Sulfone

  摘要：

  AbstractA series of molecules containing monopropargyl sulfone or 1, 2‐bis‐propargyl sulfone were synthesized. The cytotoxicity of these compounds against human carcinoma cells was also examined. This study indicated that the formation of a biradical intermediate is important to the potency of cytotoxicity.

  DOI：

  10.1002/jccs.199800118