1-(1,3-Benzodioxol-5-ylmethyl)-4-(3,4-dimethoxyphenyl)sulfonylpiperazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(1,3-Benzodioxol-5-ylmethyl)-4-(3,4-dimethoxyphenyl)sulfonylpiperazine
• 英文别名: 1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3,4-dimethoxyphenyl)sulfonyl]piperazine
• 化学式: C₂₀H₂₄N₂O₆S
• mdl: MFCD03715241
• 分子量: 420.486
• InChiKey: VCXFUNANQCIFOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  85.9
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  3,4-二甲氧基苯磺酰氯 、 1-胡椒基哌嗪 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 2.0h， 生成 1-(1,3-Benzodioxol-5-ylmethyl)-4-(3,4-dimethoxyphenyl)sulfonylpiperazine
  参考文献：
  名称：

  Alternative base matrices for solid phase quenching reagents

  摘要：

  In this paper we describe the use of macroporous, highly cross-linked poly(styrene-divinylbenzene) as a base matrix for solid phase scavengers. We demonstrate that this matrix is superior to the more traditional Merrifield resins when non-swelling solvents like acetonitrile are used. A small library of sulfonamides is generated in high purity as an example. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00192-1

文献信息

• Alternative base matrices for solid phase quenching reagents
  作者：Robert B Nicewonger、Lori Ditto、Laszlo Varady

  DOI：10.1016/s0040-4039(00)00192-1

  日期：2000.4

  In this paper we describe the use of macroporous, highly cross-linked poly(styrene-divinylbenzene) as a base matrix for solid phase scavengers. We demonstrate that this matrix is superior to the more traditional Merrifield resins when non-swelling solvents like acetonitrile are used. A small library of sulfonamides is generated in high purity as an example. (C) 2000 Elsevier Science Ltd. All rights reserved.