5-amino-1H-pyrimidine-2,4-dithione | 14623-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-amino-1H-pyrimidine-2,4-dithione
• 英文别名: 5-Amino-1H-pyrimidin-2,4-dithion；5-amino-1H-pyrimidine-2,4-dithione
• CAS: 14623-60-0
• 化学式: C₄H₅N₃S₂
• 分子量: 159.236
• InChiKey: DRNPXVXNNBCQQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-amino-1H-pyrimidine-2,4-dithione 在 1,4-二氧六环 作用下， 生成 5-ethylmercapto-1H-thiazolo[5,4-d]pyrimidin-2-one
  参考文献：
  名称：

  Inoue, Chemical and pharmaceutical bulletin, 1958, vol. 6, p. 675,678

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二氯-5 硝基嘧啶 在 sodium hydrogensulfide 、 乙醇 作用下， 生成 5-amino-1H-pyrimidine-2,4-dithione
  参考文献：
  名称：

  354. 5-氨基嘧啶的新合成及其化学性质

  摘要：

  DOI：

  10.1039/jr9510001565

文献信息

• N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS
  申请人：Rodgers James D.

  公开号：US20100298334A1

  公开（公告）日：2010-11-25

  The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

  本发明涉及式I的N-(杂)芳基吡咯烷衍生物： 这些是JAK抑制剂，如选择性JAK1抑制剂，在治疗JAK相关疾病方面具有用处，例如炎症和自身免疫性疾病，以及癌症。
• Conditioning of Skeletal Muscles in Adult and Old Mice for Protection From Contraction-Induced Injury
  作者：S. V. Brooks、J. A. Opiteck、J. A. Faulkner

  DOI：10.1093/gerona/56.4.b163

  日期：2001.4.1

  The purpose of this study was to design a conditioning program that protected muscles in both adult and old mice from a protocol of contractions that previously caused a significant number of damaged fibers and a deficit in force, Hind-limb dorsiflexor muscles of adult (7 months) and old (22 months) female B6D2F1 mice were exposed once a week to a protocol of repeated forced stretches while maximally activated in vivo. By week 4, muscles of adult, but not old, mice showed no force deficit. Conditioning was continued for 6 weeks, when both age groups showed no force deficit for two consecutive weeks. Three days after the sixth contraction protocol, when morphological damage and force deficits are most severe, the numbers of damaged fibers in muscles of adult and old mice were not different from those in uninjured control muscles and the force deficits were reduced dramatically compared with unconditioned muscles. We conclude that muscles of both adult and old mice conditioned successfully, but muscles of old mice conditioned more slowly than those of adult mice.
• Inoue, Chemical and pharmaceutical bulletin, 1958, vol. 6, p. 352,354
  作者：Inoue

  DOI：——

  日期：——
• Fluorine-Containing Potential Anticancer Agents. II.^1a Syntheses of Some Trifluoromethylpurines and Trifluoromethylthiazolopyrimidines^1b
  作者：Hideo Nagano、Shoji Inoue、Andrew J. Saggiomo、Edward A. Nodiff

  DOI：10.1021/jm00332a020

  日期：1964.3
• 354. A new synthesis and the chemical properties of 5-aminopyrimidine
  作者：N. Whittaker、T. S. G. Jones

  DOI：10.1039/jr9510001565

  日期：——