3-乙烯基-5,5-二甲基咪唑烷-2,4-二酮 | 31787-67-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 3-乙烯基-5,5-二甲基咪唑烷-2,4-二酮
• 英文名称: 3-Vinyl-5,5-dimethylhydantoin
• 英文别名: 5,5-Dimethyl-3-vinyl-imidazolidine-2,4-dione；3-ethenyl-5,5-dimethylimidazolidine-2,4-dione
• CAS: 31787-67-4
• 化学式: C₇H₁₀N₂O₂
• 分子量: 154.169
• InChiKey: ZRSMPTDXXYTVIU-UHFFFAOYSA-N

物化性质

• 熔点：
  90-91 °C
• 沸点：
  115-118 °C(Press: 0.1 Torr)
• 密度：
  1.203±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5,5-二甲基海因 、 乙炔 在 [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II) 、 三丁基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以38%的产率得到3-乙烯基-5,5-二甲基咪唑烷-2,4-二酮
  参考文献：
  名称：

  钌在低乙炔压力下催化合成乙烯基酰胺。

  摘要：

  使用钌膦催化剂，使环酰胺在低压下与乙炔反应，得到各种N-乙烯基化的酰胺，包括（氮杂双环）内酰胺，恶唑烷酮，苯并异恶唑酮，异吲哚啉酮，喹喔啉酮，恶唑烷酮，环脲衍生物（咪唑啉基） （胸腺嘧啶），氨基酸酸酐和噻唑烷酮。

  DOI：

  10.1039/d0cc01533d

文献信息

• Hydantoins having RNase modulatory activity
  申请人：Olson W. Matthew

  公开号：US20050203156A1

  公开（公告）日：2005-09-15

  The present invention relates to hydantoin derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the hydantoin derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the hydantoin derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.

  本发明涉及具有RNase H、聚合酶和/或HIV逆转录酶调节活性，特别是抑制活性的咪唑烷酮衍生物。该发明包括咪唑烷酮衍生物、含有这些衍生物的组合物、合成这些衍生物的方法、筛选方法以识别这些衍生物，以及使用这些咪唑烷酮衍生物进行治疗的方法，包括治疗HIV、艾滋病和逆转录病毒相关癌症的方法。
• Hydantoins Having RNase Modulatory Activity
  申请人：Olson Matthew W.

  公开号：US20100063118A1

  公开（公告）日：2010-03-11

  The present invention relates to hydantoin derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the hydantoin derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the hydantoin derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.

  本发明涉及具有RNase H、聚合酶和/或HIV反转录酶调节活性的咪唑二酮衍生物，特别是具有抑制活性的咪唑二酮衍生物。该发明包括咪唑二酮衍生物、含有该衍生物的组合物、合成该衍生物的方法、筛选识别该衍生物的方法以及使用咪唑二酮衍生物的治疗方法，包括治疗HIV、艾滋病和逆转录病毒相关癌症的方法。
• CuF₂/DMAP-Catalyzed N-Vinylation: Scope and Mechanistic Study
  作者：Krishanu Mondal、Susanta Patra、Pallabi Halder、Narottam Mukhopadhyay、Parthasarathi Das

  DOI：10.1021/acs.orglett.2c03856

  日期：2023.3.3
• Cell-culturing substrate, cell-culturing substrate unit bioreactor and extracorporeal circulation type therapeutic apparatus
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP0402272B1

  公开（公告）日：1995-10-04
• PRESSURE-SENSITIVE ADHESIVE COMPOSITION, PRESSURE-SENSITIVE ADHESIVE SHEET AND METHOD FOR PRODUCING PRESSURE-SENSITIVE ADHESIVE SHEET
  申请人：NIWA Masahito

  公开号：US20110159195A1

  公开（公告）日：2011-06-30

  The present invention relates to an acrylic pressure-sensitive adhesive composition comprising a copolymerization reaction product of a monomer mixture satisfying the following both conditions: (a) the monomer mixture includes a monomer m1 in an amount of 50% by mass or more based on whole monomer components constituting the monomer mixture, wherein the monomer m1 is an alkyl (meth)acrylate represented by the following formula (I): CH 2 ═C(R 1 )COOR 2 (I) wherein R 1 represents a hydrogen atom or a methyl group, and R 2 represents an alkyl group having from 1 to 20 carbon atoms; and (b) the monomer mixture includes a monomer m2 in an amount of 12% by mass or more based on the whole monomer components constituting the monomer mixture, or a monomer m2 and a monomer m3 in an amount in total of 12% by mass or more based on the whole monomer components constituting the monomer mixture, wherein the monomer m2 is an imidazole group-containing unsaturated monomer, and the monomer m3 is an amide group-containing unsaturated monomer.

表征谱图