苯基金刚烷基哌啶 | 72241-99-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 苯基金刚烷基哌啶
• 中文别名: β.-D-核-六吡喃糖,1,6-脱水-3-脱氧-4-O-甲基-6-C-苯基-2-O-(苯基甲基)-,(6S)-
• 英文名称: 1-(2-phenyl-2-adamantyl)piperidine
• 英文别名: 2-phenyl-2-piperidinoadamantane；1-(Phenyladamantan-2-yl)piperidine；1-(2-phenyl-adamantan-2-yl)-piperidine；Phenyladamantylpiperidine
• CAS: 72241-99-7
• 化学式: C₂₁H₂₉N
• 分子量: 295.468
• InChiKey: KBLCCZWZKWPYJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  金刚烷酮 以 乙醚 、 水 、 苯 为溶剂， 反应 2.0h， 生成 苯基金刚烷基哌啶
  参考文献：
  名称：

  Fotadar, Upinder, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 11, p. 1006 - 1007

  摘要：

  DOI：

文献信息

• Synthesis and biological activity of phencyclidine and its adamantylamine derivatives
  作者：A Ferle-Vidović、M Kaštelan、D Petrović、L Šuman、M Kaselj、D Škare、K Mlinarić-Majerski

  DOI：10.1016/0223-5234(93)90140-a

  日期：1993.1

  1-(2-Phenyl-2-adamantyl)amines 2a-c were synthesized and their biological activity evaluated by in vitro testing of their effects on the proliferative and reproductive ability of a human tumor cell strain and nonmalignant mouse and hamster fibroblasts in culture, and these effects compared with those of phencyclidine 1. Experiments with asynchronously growing cell populations revealed inhibition of proliferation in both normal and malignant cell strains in the presence of 10(-5) M 1 and of morpholine derivative 2c. However, there were no changes in growth rate in the presence of the 2 adamantyl derivatives 2a and 2b. Reduction of survival in both normal and malignant cell strains was also observed, but at higher concentrations and with less toxic side effects of 2a and 2b. Combined effects of the adamantyl derivatives 2a-c and ionizing irradiation were also studied by determination of cell survival. No radiation-modifying effect was observed. Investigation of these compounds in mice showed significantly less toxicity and enhanced anesthetic effect of the adamantyl derivatives 2a-b than of phencyclidine itself.
• FOTADAR, UPINDER, INDIAN J. CHEM., 1981, 20, N 11, 1006-1007
  作者：FOTADAR, UPINDER

  DOI：——

  日期：——
• Fotadar, Upinder, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 11, p. 1006 - 1007
  作者：Fotadar, Upinder

  DOI：——

  日期：——