dicyclohexylbromophosphine | 100384-03-0

• 分子结构分类: 有机化合物 - 有机磷化合物 - 烷基卤代膦
• 英文名称: dicyclohexylbromophosphine
• 英文别名: bromo-dicyclohexyl-phosphine；Brom-dicyclohexyl-phosphin；Bromo(dicyclohexyl)phosphane
• CAS: 100384-03-0
• 化学式: C₁₂H₂₂BrP
• 分子量: 277.184
• InChiKey: SCUJZKWBTRNTDD-UHFFFAOYSA-N

物化性质

• 沸点：
  171 °C(Press: 12 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dicyclohexylbromophosphine 、 2-溴乙酸苄酯 反应 72.0h， 生成 Benzyl dicyclohexylphosphinyl acetate
  参考文献：
  名称：

  Diarylphosphine- and dialkylphosphine-containing compounds, processes of preparing same and uses thereof as tridentate ligands

  摘要：

  公开了一种制备含有一个或多个二芳基膦和/或二烷基膦电子给体基团的三齿配体的新工艺。公开了使用该工艺制备这种三齿配体和含有同样三齿配体的有机金属配合物的组合化学库。进一步公开了新的含有二芳基膦和二烷基膦的化合物，可以作为三齿配体（例如夹子配体），这种三齿配体的组合化学库，含有这些配体（例如夹子配合物）的有机金属配合物和这些配合物的组合化学库。公开了利用这些库筛选候选有机金属催化剂的方法。还公开了用于制备三齿配体的新前体分子和制备这些分子的工艺。

  公开号：

  US08318960B2
• 作为产物：
  描述：

  P-环己基-N,N-二乙基胺基亚磷酰氯 在 盐酸 、 溴 、 sodium 作用下， 生成 dicyclohexylbromophosphine
  参考文献：
  名称：

  Issleib; Seidel, Chemische Berichte, 1959, vol. 92, p. 2681,2691

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES<br/>[FR] PROCEDE DE PREPARATION DE BIARYLDIPHOSPHINES A SUBSTITUTION ASYMETRIQUE
  申请人：LONZA AG

  公开号：WO2006002730A1

  公开（公告）日：2006-01-12

  Provided is a process for the preparation of asymmetrically substituted biaryldiphosphine ligands of the formula (I), wherein R1 is C1-6-alkyl or C3-10-cycloalkyl optionally substituted with one or more halogen atoms, and R2 and R3 are equal and are selected from the group consisting of aryl, C5-10-cycloalkyl and C1-6-alkyl, or R2 is C5-10-cycloalkyl or C1-6-alkyl, and R3 is aryl optionally substituted with one or more substituents selected from the group consisting of halogen atoms, nitro, amino, C1-6-alkyl, C1-6-alkoxy and di-C1-6-alkylamino groups, and each C1-6-alkyl, C5-10-cycloalkyl, C1-6-alkoxy and di-C1-6-alkylamino group in R2 and R3 optionally being substituted with one or more halogen atoms, from 2,2’,6,6’-tetrabromobiphenyl by a sequence of brominemetal exchanges and subsequent reactions.

  提供了一种制备公式（I）的不对称取代双芳基二膦配体的方法，其中R1是C1-6-烷基或C3-10环烷基，可选择地取代一个或多个卤素原子，而R2和R3相等，选自芳基、C5-10环烷基和C1-6烷基的群体，或者R2是C5-10环烷基或C1-6烷基，而R3是芳基，可选择地取代一个或多个来自卤素原子、硝基、氨基、C1-6烷基、C1-6烷氧基和双C1-6烷基氨基团的取代基，R2和R3中的每个C1-6烷基、C5-10环烷基、C1-6烷氧基和双C1-6烷基氨基团可选择地取代一个或多个卤素原子，通过一系列溴金属交换和随后的反应从2,2',6,6'-四溴联苯制备。
• Process for the preparation of asymmetrically substituted biaryldiphosphines
  申请人：Lonza AG

  公开号：EP1609795A1

  公开（公告）日：2005-12-28

  Provided is a process for the preparation of asymmetrically substituted biaryldiphosphine ligands of the formula wherein R1 is C1-6-alkyl or C3-10-cycloalkyl optionally being substituted with one or more halogen atoms, and R2 and R3 are independently selected from the group consisting of aryl, C5-10-cycloalkyl and C1-6-alkyl, wherein each aryl moiety is optionally substituted with one or more substituents selected from the group consisting of halogen atoms, nitro, amino, C1-6-alkyl, C1-6-alkoxy and di-C1-6-alkylamino groups, and each C1-6-alkyl, C1-6-alkoxy, di-C1-6-alkylamino and C5-10-cycloalkyl group in R2 and R3 optionally being substituted with one or more halogen atoms, from 2,2',6,6'-tetrabromobiphenyl by a sequence of halogen-metal exchanges and subsequent reactions.

  提供了一种制备不对称取代双芳基二膦配体的过程，其化学式如下：其中R1为C1-6-烷基或C3-10环烷基，可选地取代有一个或多个卤素原子，而R2和R3分别选自芳基、C5-10环烷基和C1-6烷基的基团，其中每个芳基基团可选地取代有一个或多个取代基，包括卤素原子、硝基、氨基、C1-6烷基、C1-6烷氧基和二C1-6烷基胺基团，R2和R3中的每个C1-6烷基、C1-6烷氧基、二C1-6烷基胺基和C5-10环烷基基团可选地取代有一个或多个卤素原子，通过一系列卤素-金属交换和随后的反应从2,2',6,6'-四溴联苯制备而得。
• Improved Syntheses of Phosphine Ligands by Direct Coupling of Diarylbromophosphine with Organometallic Reagents
  作者：Lei Liu、Hai-Chen Wu、Jin-Quan Yu

  DOI：10.1002/chem.201101467

  日期：2011.9.19

  crucial for their direct coupling with binaphthylmagnesium bromide or BINOL triflate. This finding has led to an improved preparation of both electron‐deficient BINAP‐type phosphine ligands and several important Buchwald's ligands.

  Br对Cl：发现使用二芳基溴膦代替二芳基氯膦对于它们与联萘基溴化镁或三氟甲磺酸BINOL的直接偶联是至关重要的。这一发现导致改进了电子不足的BINAP型膦配体和一些重要的布赫瓦尔德配体的制备。
• ORGANIC MAGNESIUM PHOSPHIDE AND MANUFACTURING METHOD THEREOF, ORGANIC MAGNESIUM PHOSPHIDE COMPLEX AND MANUFACTURING METHOD THEREOF, AND MANUFACTURING METHOD OF ORGANIC PHOSPHORUS COMPOUND USING SAID PHOSPHIDE
  申请人：HOKKO CHEMICAL INDUSTRY CO., LTD.

  公开号：US20190248815A1

  公开（公告）日：2019-08-15

  An organic magnesium phosphide expressed by Formula (1) below and an organic magnesium phosphide complex expressed by Formula (9) below are provided, and a manufacturing method of organic phosphorus compound is characterized in that the above compounds used as a reagent is reacted with an electrophile: wherein R 1 and R 2 are each independently an aliphatic group, heteroaliphatic group, alicyclic group, or heterocyclic group, and X is chlorine, bromine, or iodine, wherein R 3 and R 4 are each independently an aliphatic group, heteroaliphatic group, aromatic group, alicyclic group, or heterocyclic group, and X and Y are each independently chlorine, bromine, or iodine.

  提供了以下公式（1）表示的有机磷化镁和以下公式（9）表示的有机磷化镁复合物，并且有机磷化合物的制备方法的特点在于将上述化合物作为试剂与电子亲和剂发生反应：其中R1和R2分别独立地为脂肪基、杂脂肪基、脂环基或杂环基，X为氯、溴或碘，其中R3和R4分别独立地为脂肪基、杂脂肪基、芳香基、脂环基或杂环基，X和Y分别独立地为氯、溴或碘。
• [EN] PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES<br/>[FR] PROCEDE POUR PREPARER DES BIARYLDIPHOSPHINES A SUBSTITUTION ASYMETRIQUE
  申请人：LONZA AG

  公开号：WO2006002731A1

  公开（公告）日：2006-01-12

  Provided is a process for the preparation of asymmetrically substituted biaryldiphosphine ligands of the formula, (I) wherein R1 is C1-6-alkyl or C3-10-cycloalkyl optionally substituted with one or more halogen atoms, and R2 and R3 are equal and are C5-10-cycloalkyl or C1-6-alkyl, or R2 is C5-10-cycloalkyl or C1-6-alkyl, and R3 is aryl optionally substituted with one or more substituents selected from the group consisting of halogen atoms, nitro, amino, C1-6-alkyl, C1-6-alkoxy and di-C1-6-alkylamino groups, and each C1-6-alkyl, C1-6-alkoxy, di-C1-6-alkylamino and C5-10-cycloalkyl group in R2 and R3 optionally being substituted with one or more halogen atoms, from 2,2’, 6, 6’-tetra-bromobiphenyl by a sequence of bromine-metal exchanges and subsequent reactions.

  提供了一种制备不对称取代的双芳基二膦配体的过程，其化学式为（I），其中R1是C1-6-烷基或C3-10-环烷基，可选择性地取代一个或多个卤原子；R2和R3相等，均为C5-10-环烷基或C1-6-烷基；或者R2是C5-10-环烷基或C1-6-烷基，R3是芳基，可选择性地取代一个或多个取代基，所述取代基选自卤原子、硝基、氨基、C1-6-烷基、C1-6-烷氧基和二C1-6-烷基氨基团；R2和R3中的每个C1-6-烷基、C1-6-烷氧基、二C1-6-烷基氨基和C5-10-环烷基团可选择性地取代一个或多个卤原子，该过程通过溴金属交换和随后的反应从2,2'，6,6'-四溴联苯进行。