phenyl N-phenylsulfamate | 85599-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl N-phenylsulfamate
• CAS: 85599-60-6
• 化学式: C₁₂H₁₁NO₃S
• 分子量: 249.29
• InChiKey: BLDIXSSTLLWASD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  phenyl N-phenylsulfamate 、 碘甲烷 在 苄基三乙基氯化铵 、 sodium carbonate 作用下， 以 苯 为溶剂， 反应 48.0h， 以11%的产率得到phenyl N-methyl-N-phenylsulfamate
  参考文献：
  名称：

  1,2,3-Benzoxathiazole 2,2-dioxides: synthesis, mechanism of hydrolysis, and reactions with nucleophiles

  摘要：

  The rates of base-induced hydrolysis of some five-membered cyclic sulfamates, X-3-(p-tolylsulfonyl)-1,2,3-benzoxathiazole 2,2-dioxides (1a, X = H; 1b, X = 5-Me; 1c, X = 5-t-Bu; 1d, X = 5-Br; 1e, X = 5-Cl; 1f, X = 5-Ac; 1g, X = 5-NO2; 8a, X = 6-NO2) were measured in aqueous acetonitrile. The hydrolyses occurred with cleavage of the endocyclic N-SO2 bond. A Hammett plot using sigma-m values for 1a-g and sigma-p for 8a had rho = +2.20. Activation enthalpies and entropies were measured for 1a and for 3-methyl-1,2,3-benzoxathiazole 2,2-dioxide (10). Volumes of activation were determined for 1g and for 8a. The mechanistic profile for hydrolysis resembled that for the saponification of the analogous sultones and cyclic sulfates. These first examples of 1,2,3-benzoxathiazole 2,2-dioxides (1a-g, 8a) were prepared by treating N-(2-hydroxyphenyl)-p-toluenesulfonamides with sulfuryl chloride and triethylamine or by oxidizing the monoxide precursors using m-chloroperbenzoic acid. Treatment of 1a with potassium fluoride gave 1,2,3-benzoxathiazole 2,2-dioxide (9), which was methylated to give 10. Sulfamate 1a was treated with various nucleophilic reagents: phenyllithium, methyllithium, potassium fluoride, methylamine, tert-butylamine, and sodium methoxide. The first three attacked the tosyl sulfur atom and cleaved the exocyclic N-SO2 bond. The amines attacked the endocyclic sulfonyl sulfur atom and cleaved the endocyclic N-SO2 bond. Sodium methoxide attacked both sulfonyl groups.

  DOI：

  10.1021/jo00023a012
• 作为产物：
  描述：

  苯基1H-咪唑-1-磺酸盐 以 二氯甲烷 、 乙腈 为溶剂， 生成 phenyl N-phenylsulfamate
  参考文献：
  名称：

  O-(Aminosulfonylation) of phenols and an example of slow hydrolytic release

  摘要：

  Sequential replacement of imidazole from sulfonyldiimidazole by phenols and then amines leads to O-arylsulfamate esters. Application of this coupling method to 19 phenols and 6 amines generates a library of 114 sulfamate esters, Ar-OSO2-NR2. A sulfamate based conjugate of ethinyl estradiol was prepared by using the steroid 3-hydroxyl as the phenol component, and an amino amide derived from linoleic acid as the amine. Hydrolysis of this conjugate was studied in aqueous buffer at pH values 2, 5, and 7.4, and (essentially identical) respective half-lives of 6.8, 6.6, and 6.7 days were observed. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.10.065

文献信息

• WATER-SOLUBLE PHENYLPYRIDAZINE DERIVATIVE AND MEDICINE CONTAINING THE SAME
  申请人：Kowa Co., Ltd.

  公开号：EP1604984A1

  公开（公告）日：2005-12-14

  A phenylpyridazine derivative represented by the formula (1) : Wherein, R1, R2, R3, X, Y, Z and n have the same meaning as defined in the specification; or a salt thereof, or a medicine containing the compound. The present invention provides water-soluble phenylpyridazine derivatives and medicines containing them, which have excellent inhibitory activity against interleukin-β production, high water solubility and high oral absorbability.

  一种由化学式（1）表示的苯基吡啶嗪衍生物：其中，R1、R2、R3、X、Y、Z和n的定义与规范中相同；或其盐，或包含该化合物的药物。本发明提供了具有出色的抑制白细胞介素-β产生活性、高水溶性和高口服吸收性的水溶性苯基吡啶嗪衍生物和含有它们的药物。
• Water-soluble phenylpyridazine compounds and compositions containing the same
  申请人：KOWA CO., LTD.

  公开号：US20030119838A1

  公开（公告）日：2003-06-26

  Compounds having the formula (1): 1 wherein R 1 represents an alkyl or alkenyl group, R 2 and R 3 each independently represent a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R 2 and R 3 may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represent a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to medicinal compositions containing them. These compounds have inhibitory activity against IL-1&bgr; production, high water solubility and good oral absorbability.

  化合物的分子式为（1）：其中R1代表烷基或烯基基团，R2和R3分别独立地代表氢原子或烷基，羟基烷基，二羟基烷基或炔基基团，或R2和R3可以与相邻的氮原子融合形成取代或未取代的含氮饱和杂环基团，X，Y和Z分别独立地代表氢原子，烷基，卤原子或类似物，n代表1至5的整数; 这些化合物具有抑制IL-1β产生的活性，高水溶性和良好的口服吸收性。同时也包括含有这些化合物的药物组合物。
• Chan–Lam coupling reaction of sulfamoyl azides with arylboronic acids for synthesis of unsymmetrical <i>N</i>-arylsulfamides
  作者：Suk-Young Won、Seo-Eun Kim、Yong-Ju Kwon、Inji Shin、Jungyeob Ham、Won-Suk Kim

  DOI：10.1039/c8ra09219b

  日期：——

  An efficient method was developed for the synthesis of unsymmetrical N-arylsulfamides using sulfamoyl azides and arylboronic acids in the presence of 10 mol% of copper chloride as the catalyst. The reaction was facilitated in MeOH in an open flask at room temperature. Unlike the coupling of sulfamides and boronic acids, the use of sulfamoyl azides was found to be beneficial with respect to the yield

  开发了一种在 10 mol% 氯化铜作为催化剂存在下使用氨磺酰叠氮化物和芳基硼​​酸合成不对称N-芳基磺酰胺的有效方法。在室温下在开口烧瓶中的MeOH中促进反应。与磺胺和硼酸的偶联不同，发现使用氨磺酰叠氮化物对产率和反应时间是有益的。
• Water-soluble phenylpyridazine derivative and medicine containing the same
  申请人：Kyotani Yoshinori

  公开号：US20060142292A1

  公开（公告）日：2006-06-29

  A phenylpyridazine derivative represented by the formula (1): Wherein, R1, R2, R3, X, Y, Z and n have the same meaning as defined in the specification; or a salt thereof, or a medicine containing the compound. The present invention provides water-soluble phenylpyridazine derivatives and medicines containing them, which have excellent inhibitory activity against interleukin-β production, high water solubility and high oral absorbability.

  一种由式（1）表示的苯基吡嗪衍生物：其中，R1、R2、R3、X、Y、Z和n的含义与说明书中定义的相同；或其盐，或含有该化合物的药物。本发明提供了水溶性苯基吡嗪衍生物及含有它们的药物，它们具有优异的抑制白细胞介素-β产生的活性，高水溶性和高口服吸收性。
• Novel pyridazine derivatives and medicines containing the same as effective ingredients
  申请人：Ohkuchi Masao

  公开号：US20050267113A1

  公开（公告）日：2005-12-01

  This invention relates to pyridazine derivatives represented by the formula (1): wherein R 1 represents a (substituted) aryl group, R 2 represents a phenyl group substituted at 4 -position by a lower alkoxyl group or a lower alkylthio group, R 3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (subsituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4 -position and the 5 -position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients. These compounds have excellent inhibitory activity against interleukin- 1 β production, and are useful as preventives and therapeutics for immmune system diseases, inflammatory diseases, ischemic diseases and the like.

  本发明涉及由式（1）表示的吡嗪衍生物：其中R1表示（取代）芳基基团，R2表示在4-位被低烷氧基基团或低烷硫基基团取代的苯基基团，R3表示低烷氧基基团、卤代低烷基基团、低环烷基基团、（取代）芳基基团、（取代）芳氧基基团、（取代）含氮杂环环残基、（取代）氨基甲酰基或低烷基甲酰基，A表示单键、低烷基亚ethylene基或低烷基亚烯基，X表示O或S，虚线表示4-位和5-位之间的碳-碳键为单键或双键，或其盐；以及包含它们作为有效成分的药物。这些化合物对白细胞介素-1β的产生有出色的抑制活性，并且可用作免疫系统疾病、炎症性疾病、缺血性疾病等的预防和治疗。