4-methyl-3-methoxycarbonyl-2,5-dihydrofuran-5-one | 54467-57-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 4-methyl-3-methoxycarbonyl-2,5-dihydrofuran-5-one
• 英文别名: 4-methyl-5-oxo-2,5-dihydro-furan-3-carboxylic acid methyl ester；4-Methyl-5-oxo-2,5-dihydro-furan-3-carbonsaeure-methylester；3-Furancarboxylic acid, 2,5-dihydro-4-methyl-5-oxo-, methyl ester；methyl 4-methyl-5-oxo-2H-furan-3-carboxylate
• CAS: 54467-57-1
• 化学式: C₇H₈O₄
• 分子量: 156.138
• InChiKey: APWXGQJNUSKIKE-UHFFFAOYSA-N

物化性质

• 沸点：
  145-147 °C(Press: 25 Torr)
• 密度：
  1.267±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-methyl-3-methoxycarbonyl-2,5-dihydrofuran-5-one 在 二异丁基氢化铝 、 potassium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 4-甲基-3-呋喃甲酸
  参考文献：
  名称：

  SYNTHESIS OF NEO-tANSHINLACTONE VIA THE PALLADIUM-MEDIATED INTRAMOLECULAR BIARYL COUPLING REACTION

  摘要：

  Neo-tanshinlactone (1) was synthesized by the intramolecular aryl-aryl coupling reaction of the precursor ester, which was prepared from the corresponding furan carboxylic acid (13) and naphthol (3), using a palladium reagent.

  DOI：

  10.3987/com-12-s(n)87
• 作为产物：
  描述：

  衣康酸二甲酯 在 盐酸 、 溴 、 三乙胺 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 4-methyl-3-methoxycarbonyl-2,5-dihydrofuran-5-one
  参考文献：
  名称：

  SYNTHESIS OF NEO-tANSHINLACTONE VIA THE PALLADIUM-MEDIATED INTRAMOLECULAR BIARYL COUPLING REACTION

  摘要：

  Neo-tanshinlactone (1) was synthesized by the intramolecular aryl-aryl coupling reaction of the precursor ester, which was prepared from the corresponding furan carboxylic acid (13) and naphthol (3), using a palladium reagent.

  DOI：

  10.3987/com-12-s(n)87

文献信息

• Cyclohydrocarbonylation of substituted alkynes and tandem cyclohydrocarbonylation–CO insertion of α-keto alkynes catalyzed by immobilized Co–Rh heterobimetallic nanoparticles
  作者：Kang Hyun Park、So Yeon Kim、Young Keun Chung

  DOI：10.1039/b416657d

  日期：——

  The use of cobalt–rhodium (Co2Rh2) heterobimetallic nanoparticles in the cyclohydrocarbonylation of substituted alkynes and tandem cyclohydrocarbonylation–CO insertion of α-keto alkynes to give 2(3H)- or 2(5H)-furanones is described.

  在取代炔烃的环氢羰基化反应中，以及通过α-酮炔烃的串联环氢羰基化-CO插入反应生成2(3H)-或2(5H)-呋喃酮的过程中，使用了钴-铑（Co₂Rh₂）异双金属纳米粒子。
• Novel substance for agricultural use and process for its production
  申请人：Kaken Pharmaceutical Co., Ltd.

  公开号：EP0332216A1

  公开（公告）日：1989-09-13

  Disclosed in the present invention are: a substance F-0368 or salts thereof having the following structural formula a method for production of the substance F-0368 or salts thereof, wherein an F-0368-substance-producing-­microorganism belonging to a genus Kitasatosporia is cultured, and the substance F-0368 is isolated and collected from the cultured substance; a method for production of the substance F-0368 or salts thereof, wherein 3-methyl-4 lower alkoxy carbonyl-2(5H)-furanone represented by the following general formula is subjected to hydrolytic reaction (where: R represents a straight or branched lower alkyl group having 1 to 6 carbon atoms); a composition which consists essntially of the substance F-0368 or salt thereof, a diluent permissible in the agricultural chemicals, and a carrier or an excipient; a preventive agent for plant diseases such as rice blast disease and bacterial leaf blight disease, which consists essentially of an effective amount of the substance F-0368 or salts thereof as the active component, a diluent permissible in the agricultural chemicals, and a carrier or an excipient; a method for preventing plant diseases, wherein plants are treated with the preventive agent; a disinfectant for agricultural use to prevent plant disease such as rice blast disease and bacterial leaf blight disease, which consists essentially of an effective amount of the substance F-0368 or salts thereof, as the active component, a diluent permissible in the agricultural chemcials, and a carrier or an excipient; materials for agricultural use containing therein the substance F-0368 or salts thereof; a method for growing plants, wherein the plants are cultivated by use of the agricultural materials; and an F-0368-­substance-producing microorganism (Kitasatosporia sp. F-­0368; FERM BP-2259).

  本发明公开了：一种具有以下结构式的物质 F-0368 或其盐类 一种生产 F-0368 物质或其盐的方法，其中培养属于 Kitasatosporia 属的产生 F-0368 物质的微生物，并从培养的物质中分离和收集 F-0368 物质； 一种生产 F-0368 物质或其盐的方法，其中对通式如下的 3-甲基-4-低烷氧基羰基-2(5H)-呋喃酮进行水解反应 其中R 代表具有 1 至 6 个碳原子的直链或支链低级烷基）；一种组合物，主要由 F-0368 物质或其盐、农用化学品允许的稀释剂以及载体或赋形剂组成；一种植物病害如稻瘟病和细菌性叶枯病的预防剂，它主要由有效量的 F-0368 物质或其盐类作为活性成分、农用化学品中允许的稀释剂和载体或赋形剂组成；一种预防植物病害的方法，其中植物用该预防剂处理；一种预防植物病害如稻瘟病和细菌性叶枯病的农用消毒剂，它主要由有效量的 F-0368 物质或其盐类作为活性成分、农用化学品中允许的稀释剂和载体或赋形剂组成；含有 F-0368 物质或其盐类的农用材料；一种植物生长方法，其中植物是通过使用农用材料培育的；以及一种产生 F-0368 物质的微生物（Kitasatosporia sp.F-0368；FERM BP-2259）。
• Palladium-Catalyzed Dehydrogenative Carbonylative Esterification of Allenoic Acids for the Synthesis of γ-Butyrolactone Derivatives
  作者：Bolin Wang、Mingzhe Ren、Nasir Iqbal、Xin Mu、Jan-E. Bäckvall、Bin Yang

  DOI：10.1021/acs.orglett.4c00572

  日期：2024.3.29

  A highly efficient dehydrogenative carbonylative esterification of allenoic acids using Pd-catalysis was developed, providing a novel approach to synthesizing esterified γ-butyrolactone derivatives with consistently good to excellent results demonstrated across over 50 examples. Additionally, we used a heterogeneous catalyst known as Pd-AmP-MCF and harnessed biomimetic-aerobic-oxidation conditions

  开发了一种使用 Pd 催化的联烯酸高效脱氢羰基化酯化方法，提供了一种合成酯化 γ-丁内酯衍生物的新方法，并在 50 多个实例中证明了始终如一的良好至优异的结果。此外，我们使用了一种称为 Pd-AmP-MCF 的多相催化剂，并利用仿生有氧氧化条件来促进该反应的实际执行。此外，我们对 γ-丁内酯产品的详细研究突显了它们在合成生物活性化合物方面的潜力。
• Buttery, Cheryl D.; Cameron, Andrew G.; Dell, Colin P., Journal of the Chemical Society. Perkin transactions I, 1990, # 6, p. 1601 - 1610
  作者：Buttery, Cheryl D.、Cameron, Andrew G.、Dell, Colin P.、Knight, David W.

  DOI：——

  日期：——
• Rekker et al., Recueil des Travaux Chimiques des Pays-Bas, 1954, vol. 73, p. 417,422
  作者：Rekker et al.

  DOI：——

  日期：——