2-chloro-4-isopropenyl-1-methyl-benzene | 17790-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-4-isopropenyl-1-methyl-benzene
• 英文别名: 2-Chlor-4-isopropenyl-1-methyl-benzol；3-Chlor-4-methyl-α-methyl-styrol；Benzene, 2-chloro-1-methyl-4-(1-methylethenyl)；2-chloro-1-methyl-4-prop-1-en-2-ylbenzene
• CAS: 17790-62-4
• 化学式: C₁₀H₁₁Cl
• 分子量: 166.65
• InChiKey: QQZYJTRFIJXTMX-UHFFFAOYSA-N

物化性质

• 沸点：
  73-74 °C(Press: 4 Torr)
• 密度：
  1.056 g/cm3(Temp: 25 °C)
• 保留指数：
  1189

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1-(3-Chlor-p-tolyl)-1-methylethanol 在 potassium hydrogensulfate 作用下， 生成 2-chloro-4-isopropenyl-1-methyl-benzene
  参考文献：
  名称：

  Bourgeois,G.; Lalande,R., Bulletin de la Societe Chimique de France, 1972, p. 4324 - 4334

  摘要：

  DOI：

文献信息

• 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP2366699A1

  公开（公告）日：2011-09-21

  The present invention relates to a compound represented by the following formula (1): wherein D1, A1, D2, R1, D3, and R2 each have the same meaning as defined in the present specification or a salt thereof. The compound represented by the formula (1) or a salt thereof has an IKKβ inhibiting activity and the like and is useful for the prevention and/or treatment of IKKβ-associated diseases or symptoms and the like.

  本发明涉及下式（1）所代表的化合物： 其中 D1、A1、D2、R1、D3 和 R2 各具有与本说明书中定义相同的含义或其盐。式（1）代表的化合物或其盐具有 IKKβ 抑制活性等，可用于预防和/或治疗 IKKβ 相关疾病或症状等。
• Some Disubstituted α-Methylstyrenes and their Polymerization Characteristics and a Comparative Study of the Refractive Indexes of Substituted Styrenes and α-Methylstyrenes¹
  作者：Guido H. Stempel、Charles Greene、Ronald Rongone、Betty Sobel、Raymond Odioso

  DOI：10.1021/ja01145a145

  日期：1951.1
• US4085165A
  申请人：——

  公开号：US4085165A

  公开（公告）日：1978-04-18
• US7183278B1
  申请人：——

  公开号：US7183278B1

  公开（公告）日：2007-02-27
• [EN] AMIDE DERIVATIVES OF BENZENE-SULFONANILIDE, PHARMACEUTICAL COMPOSITION THEREOF AND METHOD FOR CANCER TREATMENT USING THE SAME<br/>[FR] DÉRIVÉS AMIDE DE BENZÈNE-SULFONANILIDE, COMPOSITION PHARMACEUTIQUE LES CONTENANT ET MÉTHODE DE TRAITEMENT DU CANCER LES UTILISANT
  申请人：UNIV STATE CLEVELAND

  公开号：WO2012054417A1

  公开（公告）日：2012-04-26

  The invention provides a compound of formula (I), a pharmaceutical composition thereof, a method of preparing a medicament for the treatment of a cancer, and a method of treating cancers. The invention exhibits merits against cancers such as significantly higher potency and effectiveness over a broader range of cancers. In formula (I), Ra is a benzyl group with alkyl and/or alkoxy; Rb is selected from H and alkyl groups; Rf is an alkyl; and R3 is selected from a (Formula) substituted phenyl, a heterocyclic group, and, Formula, wherein Rc is selected from a fused ring, fused rings, and any bivalent cyclic group. Formula (I)