2-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)pyridine
• 英文别名: 2-[1-[3-(Trifluoromethyl)phenyl]triazol-4-yl]pyridine；2-[1-[3-(trifluoromethyl)phenyl]triazol-4-yl]pyridine
• 化学式: C₁₄H₉F₃N₄
• 分子量: 290.247
• InChiKey: VLBYZBLYORMMNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  间氨基三氟甲苯 在 盐酸 、 copper(II) sulfate 、 维生素 C 作用下， 以 水 、 乙腈 为溶剂， 反应 2.67h， 生成 2-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)pyridine
  参考文献：
  名称：

  A comparison of novel organoiridium(III) complexes and their ligands as a potential treatment for prostate cancer

  摘要：

  A range of 1,4-substituted 2-pyridyl-N-phenyl triazoles were synthesised and evaluated for their anti proliferative properties against lymph node cancer of the prostate (LNCaP) and bone metastasis of prostate cancer (PC-3) cells. Excellent-to-low IC50 values were determined (5.6-250 mu M), and a representative group of 4 ligands were then complexed to iridium(III) giving highly luminescent species. Re-evaluation of these compounds against both cell lines was then undertaken and improved potency (up to 72-fold) was observed, giving IC50 values of 0.36-11 mu M for LNCaP and 0.85-5.9 mu M for PC-3. Preliminary screens for in vivo toxicity were conducted using a zebrafish model showing a wide range of induced toxicity depending of the compound evaluated. Apoptosis and Caspase-3 levels were also determined and showed no statistical difference between some of the treated specimens and the controls. This study may identify novel therapeutic agents for advanced stage of prostate cancer in humans. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.12.035

文献信息

• PVP coated copper–iron oxide nanocomposite as an efficient catalyst for Click reactions
  作者：Neha Joshi、Shaibal Banerjee

  DOI：10.1016/j.tetlet.2015.05.011

  日期：2015.7

  A highly efficient Polyvinylpyrrolidone (PVP) coated copper–iron oxide magnetic nanoparticles as catalyst has been developed for the Huisgen 1,3-dipolar cycloaddition reactions between organic azides and terminal alkynes which is known to be the best example in click chemistry. The in situ generated Cu(I) species is the catalytically active species for click reaction. Wide ranges of 1,2,3 triazoles

  已经开发出一种高效的聚乙烯吡咯烷酮（PVP）涂层铜-氧化铁磁性纳米粒子作为催化剂，用于有机叠氮化物和末端炔烃之间的Huisgen 1,3-偶极环加成反应，众所周知，这是点击化学的最佳实例。原位生成的Cu（I）物种是点击反应的催化活性物种。通过在室温下使用催化剂，已经以良好的产率合成了宽范围的1,2,3三唑。可以通过施加外部磁场来回收该纳米催化剂，该外部磁场导致无需过滤就可以容易地分离催化剂，并且可以在不损失其显着活性的情况下重复使用三次。该催化剂通过FT-IR，XRD，XPS，FESEM和TEM表征。